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Infectious Diseases >> Filaria


  1. Identification of microfilariae by microscopic examination is the conventional method for diagnosing active infection but this is not always feasible as microfilariae are nocturnally periodic means that they only circulate in the blood at night.
  2. Immunodiagnosis Method:

            SEVAFILACHEK (IgG & Ag assay) dipstick based ELISA system has been explored in several ways at MGIMS using penicillinase enzyme, microfilarial excretory secretory antigen and filarial antibodies in diagnosis of filarial infection in different clinical groups.  The detection of IgG antibody (titre 1:300 & above) against specific microfilarial antigen was found to be useful for detecting microfilaraemic and most of the clinical filarial cases. Free and immune complexed filarial antigens (titre 1:300 & above) are detected using filarial serum immunoglobulin G (FSIgG). Filarial antigen detection was found to be more useful in epididymoorchitis and allergic state such as Tropical eosinophilia.  The test system showed a sensitivity and specificity of about 80%.

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Bioinformatics Centre
Jamnalal Bajaj Tropical Disease Research Centre
Mahatma Gandhi Institute of Medical Sciences, Sevagram - 442 102