MENINGITIS  

January, 2005

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

11071.  Bryant PA, Li HY, Zaia A, Griffith J, Hogg G, Curtis N, Carapetis JR. Prospective study of a real-time PCR that is highly sensitive, specific, and clinically useful for diagnosis of meningococcal disease in children. J Clin Microbiol. 2004 Jul;42(7):2919-25.

11072.  Daikos GL, Brooks JB, Michos A, Roma E, Syriopoulou V. Detection of tuberculostearic acid in serum and other biological fluids from patients with tuberculosis by electron capture-gas chromatography and chemical ionisation-mass spectrometry. Int J Tuberc Lung Dis. 2004 Aug;8(8):1027-31.

11073.  Feikin DR, Nelson CB, Watt JP, Mohsni E, Wenger JD, Levine OS. Rapid assessment tool for Haemophilus influenzae type b disease in developing countries. Emerg Infect Dis. 2004 Jul;10(7):1270-6.

11074.  Johansen IS, Lundgren B, Tabak F, Petrini B, Hosoglu S, Saltoglu N, Thomsen VØ.  Improved sensitivity of nucleic acid amplification for rapid diagnosis of tuberculous meningitis. J Clin Microbiol. 2004 Jul;42(7):3036-40.

11075.  Lolge S, Chawla A, Shah J, Patkar D, Seth M. MRI of spinal intradural arachnoid cyst formation following tuberculous meningitis. Br J Radiol. 2004 Aug;77(920):681-4.

11076.  Nigrovic LE, Kuppermann N, McAdam AJ, Malley R. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J. 2004 Aug;23(8):786-8.

Pathogenesis:

11077.  Baraldo K, Mori E, Bartoloni A, Petracca R, Giannozzi A, Norelli F, Rappuoli R, Grandi G, Del Giudice G. N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines. Infect Immun. 2004 Aug;72(8):4884-7.

11078.  Das M. India leads meningitis A vaccine development. Lancet Infect Dis. 2004 Aug;4(8):478.

11079.  Kawashima H, Morishima T, Togashi T, Yokota S, Yamanaka G, Ioi H, Kashiwagi Y, Takekuma K, Hoshika A, Watanabe Y. Extraordinary changes in excitatory amino acid levels in cerebrospinal fluid of influenza-associated encephalopathy of children. Neurochem Res. 2004 Aug;29(8):1537-40.

11080.  Stojanov S, Weiss M, Lohse P, Belohradsky BH. A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy. Pediatrics. 2004 Jul;114(1):e124-7.

Vaccines:

11081.  Getsios D, Caro I, El-Hadi W, Caro JJ. Assessing the economics of vaccination for Neisseria meningitidis in industrialized nations: a review and recommendations for further research. Int J Technol Assess Health Care. 2004 Summer;20(3):280-8. Review.

Therapy:

11082.  Kedare K, Tendolkar U, Gogate A, Bichile L. Microbiological study of cryptococcus in CSF with special reference to HIV status and clinico pathological correlation. Indian Practitioner. 2004 Feb; 57(2): 67-71. 

11083.  van der Flier M, Hoppenreijs S, van Rensburg AJ, Ruyken M, Kolk AH, Springer P, Hoepelman AI, Geelen SP, Kimpen JL, Schoeman JF. Vascular endothelial growth factor and blood-brain barrier disruption in tuberculous meningitis. Pediatr Infect Dis J. 2004 Jul;23(7):608-13.

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April, 2005

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

11630.     Archimbaud C, Mirand A, Chambon M, Regagnon C, Bailly JL, Peigue-Lafeuille H, Henquell C. Improved diagnosis on a daily basis of enterovirus meningitis using a one-step real-time RT-PCR assay. J Med Virol. 2004 Dec;74(4):604-11.

11631.     Bosma GP, Steens SC, Petropoulos H, Admiraal-Behloul F, van den Haak A, Doornbos J, Huizinga TW, Brooks WM, Harville A, Sibbitt WL Jr, van Buchem MA. Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus. Arthritis Rheum. 2004 Oct;50(10):3195-202.

11632.     Ehling R, Lutterotti A, Wanschitz J, Khalil M, Gneiss C, Deisenhammer F, Reindl M, Berger T. Increased frequencies of serum antibodies to neurofilament light in patients with primary chronic progressive multiple sclerosis. Mult Scler. 2004 Dec;10(6):601-6.

11633.     Gaur A, Seshan SV. CSFC-reactive protein estimation for bedside diagnosis of pyogenic meningitis. Indian Pediatrics. 2004 Oct; 41(10): 1073-1074

11634.     Guarner J, Greer PW, Whitney A, Shieh WJ, Fischer M, White EH, Carlone GM, Stephens DS, Popovic T, Zaki SR. Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays. Am J Clin Pathol. 2004 Nov;122(5):754-64.

11635.     Litt DJ, Savino S, Beddek A, Comanducci M, Sandiford C, Stevens J, Levin M, Ison C, Pizza M, Rappuoli R, Kroll JS. Putative vaccine antigens from Neisseria meningitidis recognized by serum antibodies of young children convalescing after meningococcal disease. J Infect Dis. 2004 Oct 15;190(8):1488-97.

11636.     Ostergaard C, Brandt C, Konradsen HB, Samuelsson S. Differences in survival, brain damage, and cerebrospinal fluid cytokine kinetics due to meningitis caused by 3 different Streptococcus pneumoniae serotypes: evaluation in humans and in 2 experimental models.  J Infect Dis. 2004 Oct 1;190(7):1212-20.

11637.     Rana S V, Singhal R K, Kartar Singh, Latakumar. Adenosine deraminase levels in cerebrospinal fluid as a diagnostic test for tuberculous meningitis in children. Indian J clin Biochem 2004, 19 (2), 5-9.

11638.     Uzuka R, Kawashima H, Hasegawa D, Ioi H, Amaha M, Kashiwagi Y, Takekuma K, Hoshika A, Chiba K. Rapid diagnosis of bacterial meningitis by using multiplex PCR and real time PCR. Pediatr Int. 2004 Oct;46(5):551-4.

11639.     van Rossum AM, Wulkan RW, Oudesluys-Murphy AM. Procalcitonin as an early marker of infection in neonates and children. Lancet Infect Dis. 2004 Oct;4(10):620-30. Review.

Pathogenesis:

11640.     Grygorczuk S, Pancewicz S, Zajkowska J, Kondrusik M, Rwierzbinska R, Hermanowska-Szpakowicz T. Concentrations of macrophage inflammatory proteins MIP-1alpha and MIP-1beta and interleukin 8 (il-8) in lyme borreliosis. Infection. 2004 Dec;32(6):350-5.

116541.     Ishiwada N, Cao LD, Kohno Y. PCR-based capsular serotype determination of Haemophilus influenzae strains recovered from Japanese paediatric patients with invasive infection. Clin Microbiol Infect. 2004 Oct;10(10):895-8.

11642.     Niizuma T, Terada K, Kosaka Y, Daimon Y, Inoue M, Ogita S, Kataoka N, Tanaka K.  Elevated serum C-reactive protein in mumps orchitis. Pediatr Infect Dis J. 2004 Oct;23(10):971.

11643.     Robinson K, Taraktsoglou M, Rowe KS, Wooldridge KG, Ala'Aldeen DA. Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cell Microbiol. 2004 Oct;6(10):927-38.

11644.     Rodriguez CA, Atkinson R, Bitar W, Whitney CG, Edwards KM, Mitchell L, Li J, Sublett J, Li CS, Liu T, Chesney PJ, Tuomanen EI. Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact. J Infect Dis. 2004 Oct 15;190(8):1481-7.

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July, 2005

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

  1. Akpede GO, Omoigberale AI, Dawodu SO, Olomu SC, Shatima DR, Apeleokha M. Referral and previous care of children with meningitis in Nigeria: implications for the presentation and outcome of meningitis in developing countries. J Neurol Sci. 2005 Jan 15;228(1):41-8.

  2. Chin RF, Neville BG, Scott RC. Meningitis is a common cause of convulsive status epilepticus with fever. Arch Dis Child. 2005 Jan;90(1):66-9.

  3. Elias J Jr, dos Santos AC, Carlotti CG Jr, Colli BO, Canheu A, Matias C, Furlanetti L, Martinez R, Takayanagui OM, Sakamoto AC, Serafini LN, Chimelli L. Central nervous system paracoccidioidomycosis: diagnosis and treatment. Surg Neurol. 2005;63 Suppl 1:S13-21; discussion S21.

  4. Gartzonika C, Vrioni G, Levidiotou S. Evaluation of a commercially available reverse transcription-PCR enzyme immunoassay (Enterovirus Consensus kit) for the diagnosis of enterovirus central nervous system infections. Clin Microbiol Infect. 2005 Feb;11(2):131-7.

  5. Gendelman HE, Persidsky Y. Infections of the nervous system. Lancet Neurol. 2005 Jan;4(1):12-3. Review.

  6. Hung JJ, Ou LS, Lee WI, Huang JL. Central nervous system infections in patients with systemic lupus erythematosus. J Rheumatol. 2005 Jan;32(1):40-3.

  7. Jin E, Ma D, Liang Y, Ji A, Gan S. MRI findings of eosinophilic myelomeningoencephalitis due to Angiostrongylus cantonensis. Clin Radiol. 2005 Feb;60(2):242-50.

  8. Korczak B, Frey J, Schrenzel J, Pluschke G, Pfister R, Ehricht R, Kuhnert P. Use of diagnostic microarrays for determination of virulence gene patterns of Escherichia coli K1, a major cause of neonatal meningitis. J Clin Microbiol. 2005 Mar;43(3):1024-31.

  9. Taha MK, Alonso JM, Cafferkey M, Caugant DA, Clarke SC, Diggle MA, Fox A, Frosch M, Gray SJ, Guiver M, Heuberger S, Kalmusova J, Kesanopoulos K, Klem AM, Kriz P, Marsh J, Molling P, Murphy K, Olcen P, Sanou O, Tzanakaki G, Vogel U. Interlaboratory comparison of PCR-based identification and genogrouping of Neisseria meningitidis. J Clin Microbiol. 2005 Jan;43(1):144-9.

  10. Teja VD, Talasila SR, Vemu L. Neurologic manifestations of HIV infection: an Indian hospital-based study. AIDS Read. 2005 Mar;15(3):139-43, C3.

  11. Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol. 2005 Mar;4(3):160-70. Review. 

  12. Yoshio T, Hirata D, Onda K, Nara H, Minota S. Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus. J Rheumatol. 2005 Jan;32(1):34-9.

Pathogenesis:

  1. Moller AS, Bjerre A, Brusletto B, Joo GB, Brandtzaeg P, Kierulf P. Chemokine patterns in meningococcal disease. J Infect Dis. 2005 Mar 1;191(5):768-75.

Vaccines:

  1.  Amir J, Louie L, Granoff DM. Naturally-acquired immunity to Neisseria meningitidis group A. Vaccine. 2005 Jan 11;23(8):977-83.

  2. Mitka M. New vaccine should ease meningitis fears. JAMA. 2005 Mar 23;293(12):1433-4. 
Therapy:

  1. Altschuler EL. Prognostic factors in adults with bacterial meningitis. N Engl J Med. 2005 Feb 3;352(5):512-5;

  2. Marras TK. Dexamethasone for tuberculous meningitis. N Engl J Med. 2005 Feb 10;352(6):628-30;

  3. Pile JC, Longworth DL. Should adults with suspected acute bacterial meningitis get adjunctive corticosteroids? Cleve Clin J Med. 2005 Jan;72(1):67-70. Review.

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October, 2005

Some Selected Abstracts:

1.

Bonsu BK, Harper MB Accuracy and test characteristics of ancillary tests of cerebrospinal fluid for predicting acute bacterial meningitis in children with low white blood cell counts in cerebrospinal fluid. Acad Emerg Med. 2005 Apr;12(4):303-9

MBChB, Division of Emergency Medicine, Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA. bonsub@pediatrics.ohio-state.edu

OBJECTIVES: To determine whether ancillary tests of cerebrospinal fluid (CSF), specifically, the total protein concentration, glucose concentration, and percent neutrophils, provide information for diagnosing acute bacterial meningitis among children with low white blood cell (WBC) count in CSF. METHODS: The authors retrospectively reviewed CSF from children aged 1 month to 18 years undergoing lumbar puncture at Children's Hospital in Boston from 1993 to 1999. Data were supplemented with CSF test results obtained from children with 0-30 WBCs/mm(3) in CSF diagnosed with acute bacterial meningitis at the same institution from 1984 to 1992. For each test, the incremental value of ancillary tests was estimated by calculating indices of performance such as the area under receiver operator characteristic curves (AUC) and interval likelihood ratios that are relatively insensitive to disease prevalence. RESULTS: Among children with 0-30 WBCs/mm(3) in CSF who met study criteria, acute bacterial meningitis was identified in ten of 7,701 (0.1%) for the period from 1993 to 1999 and supplemented with 11 additional cases for the period from 1984 to 1992. AUC values for ancillary tests were 0.61 for total protein concentration, 0.69 for glucose concentration, and 0.90 for percent neutrophils. Interval likelihood ratios were unremarkable for mildly abnormal test results. In contrast, interval likelihood ratios for markedly abnormal test results were higher: 22 for total protein concentration >120 mg/dL, 57 for neutrophils >75%, 15 for glucose concentration <20 mg/dL, and 20 for glucose concentration >120 mg/dL. CONCLUSIONS: When markedly abnormal, results of CSF total protein concentration, glucose concentration, and percent neutrophils have value for diagnosing acute bacterial meningitis, even among children with a low WBC count in CSF.

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

12818.  Bang AT, Bang RA, Reddy MH, Baitule SB, Deshmukh MD, Paul VK, de C Marshal TF. Simple clinical criteria to identify sepsis or pneumonia in neonates in the community needing treatment or referral. Pediatr Infect Dis J. 2005 Apr;24(4):335-41.

12819.  Bonsu BK, Harper MB. Accuracy and test characteristics of ancillary tests of cerebrospinal fluid for predicting acute bacterial meningitis in children with low white blood cell counts in cerebrospinal fluid. Acad Emerg Med. 2005 Apr;12(4):303-9.

12820. Chamberlain MC. Neoplastic meningitis. J Clin Oncol. 2005 May 20;23(15):3605-13. Review.

12821.  Dixit R, Dixit K, Dixit R. Acute purulent pericarditis due to citrobacter freundii: a case report and literature review. Lung India. 2005 Jan-Mar; 22(1): 22-26.

12822.  Estep M. Meningococcal meningitis in critical care: an overview, new treatments/preventions, and a case study. Crit Care Nurs Q. 2005 Apr-Jun;28(2):111-21. Review.

12823.  Koranyi KI, Barson WJ, Studley JK. Meningitis in a young infant. Pediatr Infect Dis J. 2005 Apr;24(4):387.

12824.  Kulkarni SP, Jaleel MA, Kadival GV. Evaluation of an in-house-developed PCR for the diagnosis of tuberculous meningitis in Indian children. J Med Microbiol. 2005 Apr;54(Pt 4):369-73.

12825.  Parmar RC, Warke S, Sira P, Kamat JR. Rapid diagnosis meningitis using reagent strips. Indian J Med Sci 2004;58(20):62-6.

12826.  Peyrefitte CN, Devetakov I, Pastorino B, Villeneuve L, Bessaud M, Stolidi P, Depaquit J, Segura L, Gravier P, Tock F, Durand F, Vagneur JP, Tolou HJ, Grandadam M. Toscana virus and acute meningitis, France. Emerg Infect Dis. 2005 May;11(5):778-80.

12827.  Prasad PL, Nair MNG, Kalghatgi AT. Childhood bacterial meningitis and usefulness of c-reactive protein. Medical Journal Armed Forces India. 2005 Jan; 61(1): 13-15.

12828.  Watanabe H, Kaji C, Anh DD, Huong Ple T, Anh NT, Huong VT, Phuong HV, Thi NT, Suu PT, Nguyet NT, Rusizoka OS, Watanabe K, Nagatake T, Oishi K.  Comparative molecular analysis of Haemophilus influenzae isolates from young children with acute lower respiratory tract infections and meningitis in Hanoi, Vietnam. J Clin Microbiol. 2005 May;43(5):2474-6.

Pathogenesis:

12829.  Donald PR, Schaaf HS, Schoeman JF. Tuberculous meningitis and miliary tuberculosis: the Rich focus revisited. J Infect. 2005 Apr;50(3):193-5.

12830.  Guihot A, Bricaire F, Bossi P. Group B streptococcal meningitis in a patient with horizontal transmission: beware of toothbrushing on Sunday mornings. J Infect. 2005 Apr;50(3):240-1.

12831.  Pracht D, Elm C, Gerber J, Bergmann S, Rohde M, Seiler M, Kim KS, Jenkinson HF, Nau R, Hammerschmidt S. PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infect Immun. 2005 May;73(5):2680-9.

12832. Yazdankhah SP, Lindstedt BA, Caugant DA. Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitidis. J Clin Microbiol. 2005 Apr;43(4):1699-705.

Vaccines:

12833.  Campos-Outcalt D. Meningococcal vaccine: New product, new recommendations. J Fam Pract. 2005 Apr;54(4):324-6. Review.

12834.  Gottlieb S. Meningitis vaccine recommended for three groups of young people. BMJ. 2005 Jun 11;330(7504):1348.

Therapy:

12835. Agarwal D, Gupta A, Mehta VS. Role of shunt surgery in pediatric tubercular meningitis with hydrocephalus. Indian Pediatrics. 2005 Mar; 42(3): 245-250.

12836.  Das Gupta A, Mania RN, Sahu GN. Treatment of HIV related tuberculosis: experience from a tertiary care hospital in eastern India. Lung India. 2005 Jan-Mar; 22(1): 5-11.

12837.  McIntyre PB, Macintyre CR, Gilmour R, Wang H. A population based study of the impact of corticosteroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis. Arch Dis Child. 2005 Apr;90(4):391-6.

12838.  Temime L, Boelle PY, Valleron AJ, Guillemot D. Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection. Epidemiol Infect. 2005 Jun;133(3):493-501.

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