Selected abstract:

1.         Panda SK, Thakral D, Rehman S. Hepatitis E virus. Rev Med Virol. 2007 May-Jun;17(3):151-80. Review. 

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. subrat@gmail.com

Hepatitis E virus (HEV) is the aetiological agent of non-HAV enterically transmitted hepatitis. It is the major cause of sporadic as well as epidemic hepatitis, which is no longer confined to Asia and developing countries but has also become a concern of the developed nations. In the Indian subcontinent, it accounts for 30-60% of sporadic hepatitis. It is generally accepted that hepatitis E is mostly self-limited and never progresses to chronicity. It has a higher mortality in pregnant women where the disease condition is accentuated with the development of fulminant liver disease. Currently, no antiviral drug or vaccine is licensed for HEV, although a vaccine candidate is in clinical trials. HEV genome is 7.2kb in size with three open reading frames (ORFs) and 5' and 3' cis acting elements, which have important roles to play in HEV replication and transcription. ORF1 codes for methyl transferase, protease, helicase and replicase; ORF2 codes for the capsid protein and ORF3 for a protein of undefined function. HEV has recently been classified in the genus Hepevirus of the family Hepeviridae. There are four major recognised genotypes with a single known serotype. The absence of a reliable in vitro propagation system is an obstacle to deciphering HEV biology. The genome of HEV has been cloned, sequenced and the infectious nature of these replicons has been established. However, questions related to replication, transcription, virus-host interactions and pathogenesis remain to be answered. This comprehensive review summarises the progress made so far in HEV research, and addresses some of the unanswered questions.


Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

16342.   Al-Mohri H, Murphy T, Lu Y, Lalonde RG, Klein MB. Evaluating liver fibrosis progression and the impact of antiretroviral therapy in HIV and hepatitis C coinfection using a noninvasive marker. J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):463-9.

16343.   Allain JP. International collaborative study proposal for the characterization of occult hepatitis B virus infection identified by nucleic acid or anti-HBc screening. Vox Sang. 2007 Apr;92(3):254-7.

16344.   Anderson JS, Rose NR, Martin JL, Eger EI, Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesth Analg. 2007 Jun;104(6):1452-3, table of contents.

16345.   Arankalle VA, Lole KS, Deshmukh TM, Chobe LP, Gandhe SS. Evaluation of human (genotype 1) and swine (genotype 4)-ORF2-based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections. J Viral Hepat. 2007 Jun;14(6):435-45.

16346.   Aslan M, Nazligul Y, Aksoy N, Yilmaz N. A case of hyperthyroidy developing in "pegylated-interferon" therapy. Dig Dis Sci. 2007 May;52(5):1194-6. 

16347.   Ayaz C, Celen M K, Colak H, Hosoglu S, Geyik M F. Comparison of lamivudine and alpha-interferon combination with alpha-interferon alone in the treatment of HBeAg-positive chronic hepatitis B. Indian J Gastroenterol 2006; 25(2): 71-3.

16348.  De Bie RM, Gladstone RM, Strafella AP, Ko JH, Lang AE. Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse. Arch Neurol. 2007 Jun;64(6):886-9.

16349.   De Mattos Camargo Grossmann S, de Aguiar MC, Teixeira R, do Carmo MA.  Oral lichen planus and chronic hepatitis C: a controversial association. Am J Clin Pathol. 2007 May;127(5):800-4.

16350.   Devi B, Jindal N, Aggarwal A, Aggarwal L. Serological evidence of HIV, hepatitis B, hepatitis C viral infections and syphilis in pregnant women of Amritsar (Punjab). J Acad clin Microbiol 2005; 7(1):21-5.

16351.   Galy O, Petit MA, Benjelloun S, Chevallier P, Chevallier M, Srivatanakul P, Karalak A, Carreira C, Lyandrat N, Essaid A, Trepo C, Hainaut P, Chemin I.  Efficient hepatitis C antigen immunohistological staining in sections of normal, cirrhotic and tumoral liver using a new monoclonal antibody directed against serum-derived HCV E2 glycoproteins. Cancer Lett. 2007 Apr 8;248(1):81-8.

16352.   Greenstone CL, Saint S, Moseley RH. Clinical problem solving. A hand-carried diagnosis. N Engl J Med. 2007 Jun 7;356(23):2407-11.

16353.   Gross JB Jr. "Maintenance" treatment for patients with cirrhosis related to hepatitis C. Clin Gastroenterol Hepatol. 2007 Apr;5(4):427-9.

16354.   Gul U, Kilic A, Demiriz M. Eosinophilic pustular folliculitis: the first case associated with hepatitis C virus. J Dermatol. 2007 Jun;34(6):397-9.

16355.   Gupta V, Hussain J U, Shally Vijay. Hepatitis-B : recent treatment. JK Sci 2006, 8(1), 9-13.

16356.   Herremans M, Bakker J, Duizer E, Vennema H, Koopmans MP. Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity. Clin Vaccine Immunol. 2007 May;14(5):562-8. 

16357.  Jain A, Aggarwal V, Chand A, Kar P.  G-6-phosphate dehydrogenase deficiency in patients with acute viral hepatitis presenting with severe hyperbilirubinemia. Indian J Gastroenterol 2006;25(2):104-5.

16358.   Kanmura S, Uto H, Kusumoto K, Ishida Y, Hasuike S, Nagata K, Hayashi K, Ido A, Stuver SO, Tsubouchi H. Early diagnostic potential for hepatocellular carcinoma using the SELDI ProteinChip system. Hepatology. 2007 Apr;45(4):948-56.

16359.   Koziel MJ, Peters MG. Viral hepatitis in HIV infection. N Engl J Med. 2007 Apr 5;356(14):1445-54. Review.

16360.   Koziolek MJ, Scheel A, Bramlage C, Groene HJ, Mueller GA, Strutz F.  Effective treatment of hepatitis C-associated immune-complex nephritis with cryoprecipitate apheresis and antiviral therapy. Clin Nephrol. 2007 Apr;67(4):245-9.

16361.   Kretzschmar E, Chudy M, Nubling CM, Ross RS, Kruse F, Trobisch H.  First case of hepatitis C virus transmission by a red blood cell concentrate after introduction of nucleic acid amplification technique screening in Germany: a comparative study with various assays. Vox Sang. 2007 May;92(4):297-301.

16362.   Kuboki M, Iino S, Okuno T, Omata M, Kiyosawa K, Kumada H, Hayashi N, Sakai T. Peginterferon alpha-2a (40 KD) plus ribavirin for the treatment of chronic hepatitis C in Japanese patients. J Gastroenterol Hepatol. 2007 May;22(5):645-52. Erratum in: J Gastroenterol Hepatol. 2007 May;22(5):768.

16363.   Maslin J, Bigaillon C, Froussard F, Enouf V, Nicand E. Acute bilateral uveitis associated with an active human herpesvirus-6 infection. J Infect. 2007 Apr;54(4):e237-40. 

16364.   Ohura T, Kobayashi K, Tazawa Y, Abukawa D, Sakamoto O, Tsuchiya S, Saheki T. Clinical pictures of 75 patients with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). J Inherit Metab Dis. 2007 Apr;30(2):139-44.  

16365.   Peron JM, Bureau C, Poirson H, Mansuy JM, Alric L, Selves J, Dupuis E, Izopet J, Vinel JP. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J Viral Hepat. 2007 May;14(5):298-303.

16366.   Rahul S, Kataria J M, Senthil Kumar N, Dhama K, Uma R, Arthur Sylvester S , Sateesh C C. Polymerase chain reaction based differentiation of various fowl adenovirus serotypes causing inclusion body hepatitis hydropericardium syndrome (IBH-HPS) of poultry in India. Indian J comp Microbiol Immunol Infect Dis 2004; 24(1):1-6.

16367.   Sawada T, Kubota K. Liver transplantation for hepatocellular carcinoma. Dig Surg. 2007;24(2):126-30.  

16368.   Schutten M, Peters D, Back NK, Beld M, Beuselinck K, Foulongne V, Geretti AM, Pandiani L, Tiemann C, Niesters HG. Multicenter evaluation of the new Abbott RealTime assays for quantitative detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol. 2007 Jun;45(6):1712-7. 

16369.   Tahara H, Kojima A, Hirokawa T, Oyama T, Naganuma A, Maruta S, Okada K, Ban S, Yoshida K, Takagi H, Mori M. Systemic sclerosis after interferon alphacon-1 therapy for hepatitis C. Intern Med. 2007;46(8):473-6.  

16370.   Tangkijvanich P, Hourpai N, Rattanatanyong P, Wisedopas N, Mahachai V, Mutirangura A. Serum LINE-1 hypomethylation as a potential prognostic marker for hepatocellular carcinoma. Clin Chim Acta. 2007 Apr;379(1-2):127-33.  

16371.  Wang L, Tsai TH, Huang CF, Ho MS, Lin DB, Ho YC, Lin SS, Wei JC, Chou MC, Yang CC. Utilizing self-prepared ELISA plates for a cross-population study of different anti-HBe IgG subclass profiles. J Med Virol. 2007 May;79(5):495-502.


16372.   Chen J, Siddiqui A. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007 Jun;81(12):6757-60.  

16373.   Fiorucci M, Boulant S, Fournillier A, Abraham JD, Lavergne JP, Paranhos-Baccala G, Inchauspe G, Bain C. Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries. J Gen Virol. 2007 Apr;88(Pt 4):1149-62.

16374.   Herzer K, Sprinzl MF, Galle PR. Hepatitis viruses: live and let die. Liver Int. 2007 Apr;27(3):293-301. Review.

16375.   Lou XM, Yao QH, Zhang Z, Peng RH, Xiong AS, Wang HK. Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants. Clin Vaccine Immunol. 2007 Apr;14(4):464-9. 

16376.   Von Landenberg P, Lehmann HW, Modrow S. Human parvovirus B19 infection and antiphospholipid antibodies. Autoimmun Rev. 2007 Apr;6(5):278-85. 


16377.   Basu S, Lurie P. Hepatitis E vaccine. N Engl J Med. 2007 Jun 7;356(23):2421-2; author reply 2421-2.

16378.   Marshall GS, Happe LE, Lunacsek OE, Szymanski MD, Woods CR, Zahn M, Russell A. Use of combination vaccines is associated with improved coverage rates. Pediatr Infect Dis J. 2007 Jun;26(6):496-500.

16379.   Newton S, Owusu-Agyei S, Ampofo W, Zandoh C, Adjuik M, Adjei G, Tchum S, Filteau S, Kirkwood BR. Vitamin A supplementation enhances infants' immune responses to hepatitis B vaccine but does not affect responses to Haemophilus influenzae type b vaccine. J Nutr. 2007 May;137(5):1272-7.

16380.   Schmitt HJ, Maechler G, Habermehl P, Knuf M, Saenger R, Begg N, Boutriau D. Immunogenicity, reactogenicity, and immune memory after primary vaccination with a novel Haemophilus influenzae-Neisseria meningitidis serogroup C conjugate vaccine. Clin Vaccine Immunol. 2007 Apr;14(4):426-34.

Chemotherapy, Immunotherapy, Management & Drugs: 

16381.   Asian Pacific Association for the Study of the Liver (APASL) Hepatitis C Working Party; McCaughan GW, Omata M, Amarapurkar D, Bowden S, Chow WC, Chutaputti A, Dore G, Gane E, Guan R, Hamid SS, Hardikar W, Hui CK, Jafri W, Jia JD, Lai MY, Wei L, Leung N, Piratvisuth T, Sarin S, Sollano J, Tateishi R. Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection. J Gastroenterol Hepatol. 2007 May;22(5):615-33.

16382.  Au WY, Leung WC. Challenges and pitfalls in prenatal screening in pregnancies involving allogeneic stem cell transplantation recipients. Bone Marrow Transplant. 2007 Apr;39(7):379-82.

16383.  Braddock M. 11th annual Inflammatory and Immune Diseases Drug Discovery and Development Summit 12-13 March 2007, San Francisco, USA. Expert Opin Investig Drugs. 2007 Jun;16(6):909-17.

16384.   Burnouf T. Modern plasma fractionation. Transfus Med Rev. 2007 Apr;21(2):101-17. Review.

16385.   Farrell GC. New hepatitis C guidelines for the Asia-Pacific region: APASL consensus statements on the diagnosis, management and treatment of hepatitis C virus infection. J Gastroenterol Hepatol. 2007 May;22(5):607-10.

16386.   Jiao LR, Szyszko T, Al-Nahhas A, Tait P, Canelo R, Stamp G, Wasan H, Lowdell C, Philips R, Thillainayagam A, Bansi D, Rubello D, Limongelli P, Woo K, Habib NA. Clinical and imaging experience with yttrium-90 microspheres in the management of unresectable liver tumours. Eur J Surg Oncol. 2007 Jun;33(5):597-602.

16387.   Jin J, Sun H, Wei H, Liu G. The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis. Invest New Drugs. 2007 Apr;25(2):95-105.

16388.   Lang L. Interim results presented at EASL from PROVE 1 clinical trial of investigational drug telaprevir in patients with genotype 1 hepatitis C. Gastroenterology. 2007 Jun;132(7):2283-4.

16389.   Okon T. Ketamine: an introduction for the pain and palliative medicine physician. Pain Physician. 2007 May;10(3):493-500. Review.

16390.   Palumbo E. Hepatitis B genotypes and response to antiviral therapy: a review. Am J Ther. 2007 May-Jun;14(3):306-9. Review.

16391.   Rottinghaus ST, Whitley RJ. Current non-AIDS antiviral chemotherapy. Expert Rev Anti Infect Ther. 2007 Apr;5(2):217-30. Review.

16392.   Ruiz-Sancho A, Sheldon J, Soriano V. Telbivudine: a new option for the treatment of chronic hepatitis B. Expert Opin Biol Ther. 2007 May;7(5):751-61. Review.

16393.   Sharma OP, Sharma S, Pattabhi V, Mahato SB, Sharma PD. A review of the hepatotoxic plant Lantana camara. Crit Rev Toxicol. 2007 May;37(4):313-52. Review.

16394.   Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 2007 Apr;39(4):293-304.  

16395.   Yeo W, Mo FK, Chan SL, Leung NW, Hui P, Lam WY, Mok TS, Lam KC, Ho WM, Koh J, Tang JW, Chan AT, Chan PK. Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy. Hepatology. 2007 Jun;45(6):1382-9.