Allergy & Asthma

Selected abstracts:

1.                  O'Byrne PM. Cytokines or their antagonists for the treatment of asthma. Chest. 2006 Jul;130(1):244-50

McMaster University, Hamilton, ON, Canada.

T helper (Th) type 2 cytokines, particularly interleukin (IL)-4, IL-5, and IL-13, may be important in the development of allergic asthma. Humanized monoclonal antibodies (MoAbs) against IL-5 and a recombinant human soluble IL-4 receptor (sIL-4R) have been developed as possible treatments. These approaches have not yet proven to be successful in patients with persistent asthma. This may suggest that neither IL-4 nor IL-5 is important in asthma pathogenesis. There is, however, insufficient information about the efficacy of sIL-4R and the anti-IL-5 MoAbs in asthma to draw any firm conclusions about the importance of these Th2 cytokines. Also, the administration of the potentially antiinflammatory cytokines IL-12 and interferon-gamma has not shown benefit in asthmatic patients. By contrast, the treatment of severe oral steroid-dependent asthma with soluble tumor necrosis factor-alpha receptor has demonstrated very promising results, suggesting that this cytokine plays an important role in the persistence of severe asthma.

Diagnosis, Diagnostics, Immunodiagnosis, Immunodiagnostics:

14998.  Najam FIE, Giasuddin ASM, Shembesh AH. Complement components (C3, C4) in childhood asthma. Indian J Pediat 2005, 72(9), 745-9

14999.  Roy-Byrne PP, Craske MG, Stein MB. Panic disorder. Lancet. 2006 Sep 16;368(9540):1023-32. Review.

15000.  Winchester DE, Jacob A, Murphy T. Omalizumab for asthma. N Engl J Med. 2006 Sep 21;355(12):1281-2.


15001.  Boyce JA.  Asthma 2005-2006: bench to bedside. J Allergy Clin Immunol. 2006 Sep;118(3):582-6. Review. 

15002.  Kahn JS. Epidemiology of human metapneumovirus. Clin Microbiol Rev. 2006 Jul;19(3):546-57. Review. 

15003.  Kim SH, Ye YM, Lee SK, Park HS. Genetic mechanism of aspirin-induced urticaria/angioedema. Curr Opin Allergy Clin Immunol. 2006 Aug;6(4):266-70. Review. 

15004.  Ku M, Silverman B, Prifti N, Ying W, Persaud Y, Schneider A. Prevalence of migraine headaches in patients with allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Aug;97(2):226-30.

15005.  Park MI, Camilleri M. Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. Neurogastroenterol Motil. 2006 Aug;18(8):595-607. Review.


15006.  Dixon AE, Kaminsky DA, Holbrook JT, Wise RA, Shade DM, Irvin CG. Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function. Chest. 2006 Aug;130(2):429-35. 

15007.  Dombkowski KJ, Davis MM, Cohn LM, Clark SJ. Effect of missed opportunities on influenza vaccination rates among children with asthma. Arch Pediatr Adolesc Med. 2006 Sep;160(9):966-71.


15008.  Huston DP. Update in allergy and immunology. Ann Intern Med. 2006 Sep 19;145(6):454-8. Review.

15009.  Langan SM, Thomas KS, Williams HC.  What is meant by a "flare" in atopic dermatitis? A systematic review and proposal. Arch Dermatol. 2006 Sep;142(9):1190-6. Review

15010.  Tonnel AB, Tillie-Leblond I. Omalizumab for asthma. N Engl J Med. 2006 Sep 21;355(12):1282.