LEISHMANIASIS
January 2006
Some Selected Abstracts: |
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1. |
Allahverdiyev AM, Bagirova M, Uzun S, Alabaz D, Aksaray N, Kocabas E, Koksal F. The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. Am J Trop Med Hyg. 2005 Aug;73(2):276-80. Cukurova University, Tropical Diseases Research Centre, Adana, Turkey. We
have demonstrated that the microculture method (MCM) enables the diagnosis
of visceral leishmaniasis (VL) with samples from both the bone marrow (BM)
and peripheral blood (PB). The MCM is superior to the traditional culture
method (TCM) as determined by its higher sensitivity in the detection of
promastigotes and the more rapid time for emergence of promastigotes. The
sensitivity of MCM (100% in BMs and 77.8-100% in PB) was considerably
higher than that of the TCM (37.5-100% in BMs and 0-100% in PB) according
to decreasing parasite density (P < 0.05). The concentration of
parasites in buffy coats has increased the sensitivity of both methods,
especially that of the MCM. Detection of promastigotes by MCM requires
lower amounts of culture media (25-50 microL) and shorter incubation
periods (2-7 days) than TCM (2.5-3.5 mL and 15-35 days, respectively). MCM
was found to be valuable with the advantages of simplicity and
sensitivity, in addition to being cost-effective in the routine diagnosis
for VL in Adana Turkey. |
Diagnosis, Diagnostics, Immunodiagnosis &
Immunodiagnostics: |
13328. Allahverdiyev AM, Bagirova M, Uzun S, Alabaz D, Aksaray N, Kocabas E, Koksal F. The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. Am J Trop Med Hyg. 2005 Aug;73(2):276-80. 13329. Manna M, Majumder HK, Sundar S, Bhaduri AN. The molecular characterization of clinical isolates from Indian Kala-azar patients by MLEE and RAPD-PCR. Med Sci Monit. 2005 Jul;11(7):BR220-7. 13330. Maurya R, Singh RK, Kumar B, Salotra P, Rai M, Sundar S. Evaluation of PCR for diagnosis of Indian kala-azar and assessment of cure. J Clin Microbiol. 2005 Jul;43(7):3038-41. 13331. Quispe-Tintaya KW, Laurent T, Decuypere S, Hide M, Banuls AL, De Doncker S, Rijal S, Canavate C, Campino L, Dujardin JC. Fluorogenic assay for molecular typing of the Leishmania donovani complex: taxonomic and clinical applications. J Infect Dis. 2005 Aug 15;192(4):685-92. 13332. Roscoe M. Leishmaaniasis: early diagnosis is key. JAAPA. 2005 Jul;18(7):47-50, 53-4. Review. |
Pathogenesis: |
13333. Castellucci L, Cheng LH, Araujo C, Guimaraes LH, Lessa H, Machado P, Almeida MF, Oliveira A, Ko A, Johnson WD, Wilson ME, Carvalho EM, DE Jesus AR. Familial aggregation of mucosal leishmaniasis in northeast Brazil. Am J Trop Med Hyg. 2005 Jul;73(1):69-73. 13334. Xavier MB, Silveira FT, Demachki S, Ferreira MM, do Nascimento JL. American tegumentary leishmaniasis: a quantitative analysis of Langerhans cells presents important differences between L. (L.) amazonensis and Viannia subgenus. Acta Trop. 2005 Jul;95(1):67-73. |
Vaccines: |
13335. Velez ID, Gilchrist K, Arbelaez MP, Rojas CA, Puerta JA, Antunes CM, Zicker F, Modabber F. Failure of a killed Leishmania amazonensis vaccine against American cutaneous leishmaniasis in Colombia. Trans R Soc Trop Med Hyg. 2005 Aug;99(8):593-8. |
Therapy: |
13336. Brown M, Noursadeghi M, Boyle J, Davidson RN. Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis. Br J Dermatol. 2005 Jul;153(1):203-5. 13337. Eastman RT, Barrett LK, Dupuis K, Buckner FS, Van Voorhis WC. Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation. Transfusion. 2005 Sep;45(9):1459-63. 13338. Guthmann JP, Arlt D, Garcia LM, Rosales M, de Jesus Sanchez J, Alvarez E, Lonlas S, Conte M, Bertoletti G, Fournier C, Huari R, Torreele E, Llanos-Cuentas A. Control of mucocutaneous leishmaniasis, a neglected disease: results of a control programme in Satipo Province, Peru. Trop Med Int Health. 2005 Sep;10(9):856-62. Back |
April 2006 Some Selected Abstracts: |
|
1. |
Faria
DR, Gollob KJ, Barbosa J Jr, Schriefer A, Machado PR, Lessa H, Carvalho
LP, Romano-Silva MA, de Jesus AR, Carvalho EM, Dutra WO. Decreased in situ
expression of interleukin-10 receptor is correlated with the exacerbated
inflammatory and cytotoxic responses observed in mucosal leishmaniasis.
Infect Immun. 2005 Dec;73(12):7853-9. Department
of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil. Human
infection with Leishmania braziliensis can lead to cutaneous leishmaniasis
(CL) or mucosal leishmaniasis (ML). We hypothesize that the intense tissue
destruction observed in ML is a consequence of an uncontrolled exacerbated
inflammatory immune response, with cytotoxic activity. For the first time,
this work identifies the cellular sources of inflammatory and
antiinflammatory cytokines, the expression of effector molecules, and the
expression of interleukin-10 (IL-10) receptor in ML and CL lesions by
using confocal microscopy. ML lesions displayed a higher number of gamma
interferon (IFN-gamma)-producing cells than did CL lesions. In both ML and
CL, CD4+ cells represented the majority of IFN-gamma-producing cells,
followed by CD8+ cells and CD4- CD8- cells. The numbers of tumor necrosis
factor alpha-positive cells, as well as those of IL-10-producing cells,
were similar in ML and CL lesions. The effector molecule granzyme A showed
greater expression in ML than in CL lesions, while inducible nitric oxide
synthase did not. Finally, the expression of IL-10 receptor was lower in
ML than in CL lesions. Thus, our data identified distinct cytokine and
cell population profiles for CL versus ML patients and provide a possible
mechanism for the development of ML disease through the demonstration that
low expression of IL-10 receptor is present in conjunction with a
cytotoxic and inflammatory profile in ML. |
2. |
Murray
HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet.
2005 Oct 29-Nov 4;366(9496):1561-77. Review.
Department
of Medicine, Weill Medical College of Cornell University, New York, USA.
hwmurray@med.cornell.edu |
Diagnosis, Diagnostics, Immunodiagnosis &
Immunodiagnostics: |
13885.
Chargui N, Bastien P, Kallel K, Haouas N, Akrout FM, Masmoudi A, Zili J,
Chaker E, Othman AD, Azaiez R, Crobu L, Mezhoud H, Babba H. Usefulness
of PCR in the diagnosis of cutaneous leishmaniasis in Tunisia. Trans R
Soc Trop Med Hyg. 2005 Oct;99(10):762-8. 13886.
Fontes CO, Carvalho MA, Nicoli JR, Hamdan JS, Mayrink W, Genaro O, Carmo
LS, Farias LM. Identification and antimicrobial susceptibility of
micro-organisms recovered from cutaneous lesions of human American
tegumentary leishmaniasis in Minas Gerais, Brazil. J Med Microbiol. 2005
Nov;54(Pt 11):1071-6. 13887.
Guddo F, Gallo E, Cillari E, La Rocca AM, Moceo P, Leslie K, Colby T,
Rizzo AG. Detection of Leishmania infantum kinetoplast DNA in laryngeal
tissue from an immunocompetent patient. Hum Pathol. 2005
Oct;36(10):1140-2. 13888.
Passos S, Carvalho LP, Orge G, Jeronimo SM, Bezerra G, Soto M, Alonso C,
Carvalho EM. Recombinant leishmania antigens for serodiagnosis of
visceral leishmaniasis. Clin Diagn Lab Immunol. 2005 Oct;12(10):1164-7. 13889.
Singh R, Subba Raju BV, Jain RK, Salotra P. Potential of direct
agglutination test based on promastigote and amastigote antigens for
serodiagnosis of post-kala-azar dermal leishmaniasis. Clin Diagn Lab
Immunol. 2005 Oct;12(10):1191-4. 13890.
Theinert SM, Basu R, Forgber M, Roy S, Sundar S, Walden P.
Identification of new antigens in visceral leishmaniasis by expression
cloning and immunoblotting with sera of kala-azar patients from Bihar,
India. Infect Immun. 2005 Oct;73(10):7018-21. 13891.
Van der Meide WF, Schoone GJ, Faber WR, Zeegelaar JE, de Vries HJ, Ozbel
Y, Lai A Fat RF, Coelho LI, Kassi M, Schallig HD. Quantitative nucleic
acid sequence-based assay as a new molecular tool for detection and
quantification of Leishmania parasites in skin biopsy samples. J Clin
Microbiol. 2005 Nov;43(11):5560-6. |
Pathogenesis: |
13892.
Barnett PG, Singh SP, Bern C, Hightower AW, Sundar S. Virgin soil: the
spread of visceral leishmaniasis into Uttar Pradesh, India. Am J Trop
Med Hyg. 2005 Oct;73(4):720-5. 13893.
Padmanabhan PK, Mukherjee A, Singh S, Chattopadhyaya S, Gowri VS, Myler
PJ, Srinivasan N, Madhubala R. Glyoxalase I from Leishmania donovani: a
potential target for anti-parasite drug. Biochem Biophys Res Commun.
2005 Dec 2;337(4):1237-48.
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Vaccines: |
13894
.
Breton M, Tremblay MJ, Ouellette M, Papadopoulou B. Live
nonpathogenic arasitic
vector as a candidate vaccine against visceral leishmaniasis. Infect
Immun. 005
Oct;73(10):6372-82. |
Therapy: |
13895.
Barratt G, Legrand P. Comparison of the efficacy and pharmacology
of formulations of amphotericin B used in treatment of leishmaniasis.
Curr Opin Infect Dis. 2005 Dec;18(6):527-30. Review. 13896. Bimal S, Singh SK, Das VN, Sinha PK, Gupta AK, Bhattacharya SK, Das P. Leishmania donovani: effect of therapy on expression of CD2 antigen and secretion of macrophage migration inhibition factor by T-cells in patients with visceral leishmaniasis. Exp Parasitol. 2005 Oct;111(2):130-2. 13897.
Olliaro PL, Guerin PJ, Gerstl S, Haaskjold AA, Rottingen JA,
Sundar S. Treatment
options for visceral leishmaniasis: a systematic review of clinical
studies done in India, 1980-2004. Lancet Infect Dis. 2005
Dec;5(12):763-74. Review. 13898. Wasunna MK, Rashid JR, Mbui J, Kirigi G, Kinoti D, Lodenyo H, Felton JM, Sabin AJ, Horton J. A phase II dose-increasing study of sitamaquine for the treatment of visceral leishmaniasis in Kenya. Am J Trop Med Hyg. 2005 Nov;73(5):871-6. |
Back |
July 2006
Diagnosis, Diagnostics, Immunodiagnosis &
Immunodiagnostics: |
14371. Caldas AJ, Costa J, Aquino D, Silva AA, Barral-Netto M, Barral A. Are there differences in clinical and laboratory parameters between children and adults with American visceral leishmaniasis? Acta Trop. 2006 Mar;97(3):252-8. 14372. Chappuis F, Rijal S, Jha UK, Desjeux P, Karki BM, Koirala S, Loutan L, Boelaert M. Field validity, reproducibility and feasibility of diagnostic tests for visceral leishmaniasis in rural Nepal. Trop Med Int Health. 2006 Jan;11(1):31-40. 14373. Hailu A, Schoone GJ, Diro E, Tesfaye A, Techane Y, Tefera T, Assefa Y, Genetu A, Kebede Y, Kebede T, Schallig HD. Field evaluation of a fast anti-Leishmania antibody detection assay in Ethiopia. Trans R Soc Trop Med Hyg. 2006 Jan;100(1):48-52. 14374. Ihalamulla RL, Rajapaksa US, Karunaweera ND. Microculture for the isolation of Leishmania, modified to increase efficacy: a follow-up to a previous study. Ann Trop Med Parasitol. 2006 Jan;100(1):87-9. 14375. Sinha PK, Pandey K, Bhattacharya SK. Diagnosis & management of leishmania/HIVco- infection. Indian J Med Res. 2005;121(4):407-14. 14376. Ritmeijer K, Melaku Y, Mueller M, Kipngetich S, O'keeffe C, Davidson RN. Evaluation of a new recombinant K39 rapid diagnostic test for Sudanese visceral leishmaniasis. Am J Trop Med Hyg. 2006 Jan;74(1):76-80. 14377. Rocha RD, Gontijo CM, Eloi-Santos SM, Teixeira-Carvalho A, Correa-Oliveira R, Ferrari TC, Marques MJ, Mayrink W, Martins-Filho OA. Clinical value of anti-live Leishmania (Viannia) braziliensis immunoglobulin G subclasses, detected by flow cytometry, for diagnosing active localized cutaneous leishmaniasis. Trop Med Int Health. 2006 Feb;11(2):156-66. 14378. Rotureau B, Ravel C, Couppie P, Pratlong F, Nacher M, Dedet JP, Carme B. Use of PCR-restriction fragment length polymorphism analysis to identify the main new world Leishmania species and analyze their taxonomic properties and polymorphism by application of the assay to clinical samples. J Clin Microbiol. 2006 Feb;44(2):459-67. |
Vaccines: |
14379. Mayrink W, Botelho AC, Magalhaes PA, Batista SM, Lima Ade O, Genaro O, Costa CA, Melo MN, Michalick MS, Williams P, Dias M, Caiaffa WT, Nascimento E, Machado-Coelho GL. Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leishmaniasis treatment. Rev Soc Bras Med Trop. 2006 Jan-Feb;39(1):14-21. |
Therapy: |
14380. Colakoglu M, Fidan Yaylali G, Yalcin Colakoglu N, Yilmaz M. Successful treatment of visceral leishmaniasis with fluconazole and allopurinol in a patient with renal failure. Scand J Infect Dis. 2006;38(3):208-10. 14381. Colakoglu M, Yaylali GF, Colakoglu NY, Yilmaz M. Successful treatment of visceral leishmaniasis with fluconazole and allopurinol in a patient with renal failure. Scand J Infect Dis. 2006;38(2):152-4. 14382. Consigli J, Danielo C, Gallerano V, Papa M, Guidi A. Cutaneous leishmaniasis: successful treatment with itraconazole. Int J Dermatol. 2006 Jan;45(1):46-9. 14383. Correa JE, Rios CH, del Rosario Castillo A, Romero LI, Ortega-Barria E, Coley PD, Kursar TA, Heller MV, Gerwick WH, Rios LC. Minor alkaloids from Guatteria dumetorum with antileishmanial activity. Planta Med. 2006 Feb;72(3):270-2. 14384. Croft SL, Sundar S, Fairlamb AH. Drug resistance in leishmaniasis. Clin Microbiol Rev. 2006 Jan;19(1):111-26. Review. 14385. Dujardin JC. Risk factors in the spread of leishmaniases: towards integrated monitoring? Trends Parasitol. 2006 Jan;22(1):4-6. 14386. Linares GE, Ravaschino EL, Rodriguez JB. Progresses in the field of drug design to combat tropical protozoan parasitic diseases. Curr Med Chem. 2006;13(3):335-60. Review. 14387. Teixeira MJ, Teixeira CR, Andrade BB, Barral-Netto M, Barral A. Chemokines in host- parasite interactions in leishmaniasis. Trends Parasitol. 2006 Jan;22(1):32-40. Back |
October 2006 Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics: 14734. Kurkjian KM, Mahmutovic AJ, Kellar KL, Haque R, Bern C, Secor WE. Multiplex analysis of circulating cytokines in the sera of patients with different clinical forms of visceral leishmaniasis. Cytometry A. 2006 May;69(5):353-8. 14735. Ansari NA, Saluja S, Salotra P. Elevated levels of interferon-gamma, interleukin-10, and interleukin-6 during active disease in Indian kala azar. Clin Immunol. 2006 Jun;119(3):339-45. Pathogenesis: 14736. Sakru N, Ozensoy Toz S, Korkmaz M, Kavakli T, Alkan MZ, Ozbel Y. The infection risk of visceral leishmaniasis among household members of active patients. Parasitol Int. 2006 Jun;55(2):131-3. Vaccines: 14737. Michel MY, Fathy FM, Hegazy EH, Hussein ED, Eissa MM, Said DE. The djuvant effects of IL-12 and BCG on autoclaved Leishmania major vaccine in experimental cutaneous leishmaniasis. J Egypt Soc Parasitol. 2006 Apr;36(1):159-76, following 76. 14738. Titus RG, Bishop JV, Mejia JS. The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission. Parasite Immunol. 2006 Apr;28(4):131-41. Review. Therapy: 14739. Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Ouellette M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med. 2006 May;3(5):e162. 14740. Hartzell JD, Aronson NE, Nagaraja S, Whitman T, Hawkes CA, Wortmann G. Varicella zoster virus meningitis complicating sodium stibogluconate treatment for cutaneous leishmaniasis. Am J Trop Med Hyg. 2006 Apr;74(4):591-2. 14741. Kuryshev YA, Wang L, Wible BA, Wan X, Ficker E. Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents. Mol Pharmacol. 2006 Apr;69(4):1216-25. 14742. Ozkan U, Oguzkurt L, Tercan F, Tokmak N. Percutaneous transhepatic hrombolysis in the treatment of acute portal venous thrombosis. Diagn Interv Radiol. 2006 Jun;12(2):105-7. 14743. Rojas R, Valderrama L, Valderrama M, Varona MX, Ouellette M, Saravia NG. Resistance to antimony and treatment failure in human Leishmania (Viannia) infection. J Infect Dis. 2006 May 15;193(10):1375-83. 14744. Schwartz E, Hatz C, Blum J. New world cutaneous leishmaniasis in travellers. Lancet Infect Dis. 2006 Jun;6(6):342-9. Review. Back |