January
2006 Some Selected Abstracts: |
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1. |
1.
Valyi-Nagy T, Dermody TS. Role
of oxidative damage in the pathogenesis of viral infections of the nervous
system. Histol Histopathol.
2005 Jul;20(3):957-67. Department
of Pathology, College of Medicine, University of Illinois at Chicago,
Chicago, Illinois, USA. Oxidative stress, primarily due to increased generation of
reactive oxygen species (ROS) and reactive nitrogen species (RNS), is a
feature of many viral infections. ROS and RNS modulate the permissiveness
of cells to viral replication, regulate host inflammatory and immune
responses, and cause oxidative damage to both host tissue and progeny
virus. The lipid-rich nervous system is particularly susceptible to lipid
peroxidation, an autocatalytic process that damages lipid-containing
structures and yields reactive by-products, which can covalently modify
and damage cellular macromolecules. Oxidative injury is a component of
acute encephalitis caused by herpes simplex virus type 1 and reovirus,
neurodegenerative disease caused by human immunodeficiency virus and
murine leukemia virus, and subacute sclerosing panencephalitis caused by
measles virus. The extent to which oxidative damage plays a beneficial
role for the host by limiting viral replication is largely unknown. An
enhanced understanding of the role of oxidative damage in viral infections
of the nervous system may lead to therapeutic strategies to reduce tissue
damage during viral infection without impeding the host antiviral
response. |
Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics: |
13228. Busch MP, Caglioti S, Robertson EF, McAuley JD, Tobler LH, Kamel H, Linnen JM, Shyamala V, Tomasulo P, Kleinman SH. Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing. N Engl J Med. 2005 Aug 4;353(5):460-7. 13229. Colmenero JD, Queipo-Ortuno MI, Reguera JM, Baeza G, Salazar JA, Morata P. Real time polymerase chain reaction: a new powerful tool for the diagnosis of neurobrucellosis. J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):1025-7. 13230. Courtioux B, Bisser S, M'belesso P, Ngoungou E, Girard M, Nangouma A, Josenando T, Jauberteau-Marchan MO, Bouteille B. Dot enzyme-linked immunosorbent assay for more reliable staging of patients with Human African trypanosomiasis. J Clin Microbiol. 2005 Sep;43(9):4789-95. 13231. Ekmekci O, Karasoy H, Gokcay A, Ulku A. Atypical EEG findings in subacute sclerosing panencephalitis. Clin Neurophysiol. 2005 Aug;116(8):1762-7. 13232. Marzocchetti A, Di Giambenedetto S, Cingolani A, Ammassari A, Cauda R, De Luca A. Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. J Clin Microbiol. 2005 Aug;43(8):4175-7. 13233. Ng'walali PM, Kibayashi K, Mbonde MP, Harada S, Mwakagile D, Kitinya JN, Tsunenari S. Neuropathology of human immunodeficiency virus infection: a forensic autopsy study in Dar Es Salaam, Tanzania. Forensic Sci Int. 2005 Jul 16;151(2-3):133-8. 13234. Prince HE, Lape-Nixon M, Busch MP, Tobler LH, Foster GA, Stramer SL. Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection. Clin Diagn Lab Immunol. 2005 Sep;12(9):1123-6. 13235. Tilley PA, Walle R, Chow A, Jayaraman GC, Fonseca K, Drebot MA, Preiksaitis J, Fox J. Clinical utility of commercial enzyme immunoassays during the inaugural season of West Nile virus activity, Alberta, Canada. J Clin Microbiol. 2005 Sep;43(9):4691-5. 13236. Tilley PA, Zachary GA, Walle R, Schnee PF. West Nile virus detection and commercial assays. Emerg Infect Dis. 2005 Jul;11(7):1154-5. 13237. Tonry JH, Brown CB, Cropp CB, Co JK, Bennett SN, Nerurkar VR, Kuberski T, Gubler DJ. West Nile virus detection in urine. Emerg Infect Dis. 2005 Aug;11(8):1294-6. |
Pathogenesis: |
13238. Kumar D, Humar A. Emerging viral infections in transplant recipients. Curr Opin Infect Dis. 2005 Aug;18(4):337-41. Review. 13239. Mandl CW. Steps of the tick-borne encephalitis virus replication cycle that affect neuropathogenesis. Virus Res. 2005 Aug;111(2):161-74. Review. 13240. Rojanawiwat A, Miura T, Thaisri H, Pathipvanich P, Umnajsirisuk S, Koibuchi T, Vongsheree S, Iwamoto A, Ariyoshi K, Sawanpanyalert P. Frequent detection of Epstein-Barr Virus and cytomegalovirus but not JC virus DNA in cerebrospinal fluid samples from human immunodeficiency virus-infected patients in northern Thailand. J Clin Microbiol. 2005 Jul;43(7):3484-6. 13241. Santagata S, Kinney HC. Mechanism of JCV entry into oligodendrocytes. Science. 2005 Jul 15;309(5733):381-2. 13242. Takemoto M, Kira R, Kusuhara K, Torisu H, Sakai Y, Hara T. Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays. J Neurovirol. 2005 Jul;11(3):299-305. 13243. Valyi-Nagy T, Dermody TS. Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol Histopathol. 2005 Jul;20(3):957-67. Review. |
Vaccines: |
13244. Chen L, Lin T, Zhang H, Su Y. Immune responses to foot-and-mouth disease DNA vaccines can be enhanced by coinjection with the Isatis indigotica extract. Intervirology. 2005 Jul-Aug;48(4):207-12. 13245. Hayes EB, Sejvar JJ, Zaki SR, Lanciotti RS, Bode AV, Campbell GL. Virology, pathology, and clinical manifestations of West Nile virus disease. Emerg Infect Dis. 2005 Aug;11(8):1174-9. Review. 13246. Yamshchikov
G, Borisevich V, Kwok CW, Nistler R, Kohlmeier J, Seregin A, Chaporgina
E, Benedict S, Yamshchikov V. The suitability of yellow fever and
Japanese encephalitis vaccines for immunization against West Nile virus.
Vaccine. 2005 Sep 15;23(39):4785-92. |
Therapy: |
13247. Adelman B, Sandrock A, Panzara MA. Natalizumab and progressive multifocal leukoencephalopathy. N Engl J Med. 2005 Jul 28;353(4):432-3. 13248. Aure K, Behin A, Louillet F, Lafitte C, Sanson M, Vernant JP. Dramatic improvement in non-AIDS related progressive multifocal leucoencephalopathy. J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1305-6. 13249. Baeuerle M, Schmitt-Haendle M, Taubald A, Mueller S, Walter H, Pfeiffer C, Manger B, Harrer T. Severe HIV-1 encephalitis and development of cerebral non-Hodgkin lymphoma in a patient with persistent strong HIV-1 replication in the brain despite potent HAART -- case report and review of the literature. Eur J Med Res. 2005 Jul 29;10(7):309-16. 13250. Berger JR, Koralnik IJ. Progressive multifocal leukoencephalopathy and natalizumab—unforeseen consequences. N Engl J Med. 2005 Jul 28;353(4):414-6. 13251. Holcomb SS. Guidelines for West Nile virus. Nurse Pract. 2005 Sep;30(9):7, 11, 14. 13252. Reilmann R, Imai T, Ringelstein EB, Gaubitz M, Niederstadt TU, Paulus W, Husstedt IW. Remission of progressive multifocal leucoencephalopathy in SLE after treatment with cidofovir: a 4 year follow up. J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1304-5. 13253. Secko D. Immunotherapy for West Nile virus infection. CMAJ. 2005 Sep 13;173(6):591. 13254. Wyen C, Lehmann C, Fatkenheuer G, Hoffmann C. AIDS-related
progressive multifocal leukoencephalopathy in the era of HAART: report
of two cases and review of the literature. AIDS Patient Care STDS. 2005
Aug; 19(8):486-94. Review. |
Back |
April
2006 Some Selected Abstracts: |
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1. |
Bellini WJ, Harcourt BH, Bowden N, Rota PA. Nipah virus: an
emergent paramyxovirus causing severe encephalitis in humans. J Neurovirol. 2005 Oct;11(5):481-7. Review. Respiratory
and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases,
National Center for Infectious Diseases, Centers for Disease Control and
Prevention, Atlanta, Georgia 30333, USA. wbellini@cdc.gov Nipah
virus is a recently emergent paramyxovirus that is capable of causing
severe disease in both humans and animals. The first outbreak of Nipah
virus occurred in Malaysia and Singapore in 1999 and, more recently,
outbreaks were detected in Bangladesh. In humans, Nipah virus causes
febrile encephalitis with respiratory syndrome that has a high mortality
rate. The reservoir for Nipah virus is believed to be fruit bats, and
humans are infected by contact with infected bats or by contact with an
intermediate animal host such as pigs. Person to person spread of the
virus has also been described. Nipah virus retains many of the genetic and
biologic properties found in other paramyxoviruses, though it also has
several unique characteristics. However, the virologic characteristics
that allow the virus to cause severe disease over a broad host range, and
the epidemiologic, environmental and virologic features that favor
transmission to humans are unknown. This review summarizes what is known
about the virology, epidemiology, pathology, diagnosis and control of this
novel pathogen. |
2.
|
1.
Hasko G, Pacher P, Vizi ES, Illes P. Adenosine receptor signaling
in the brain immune system. Trends Pharmacol Sci. 2005 Oct;26(10):511-6.
Review. Department
of Surgery, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.
haskoge@umdnj.edu |
3. |
Mackenzie JS. Emerging zoonotic encephalitis viruses: lessons from
Southeast Asia and Oceania. J Neurovirol. 2005 Oct;11(5):434-40. Review. Australian
Biosecurity CRC, Curtin University of Technology, Perth, Western
Australia, Australia. Mackenzie@curtin.edu.au . |
4. |
Marchetti B,
Abbracchio MP. To be or not to be (inflamed)--is that the question in
anti-inflammatory drug therapy of neurodegenerative disorders? Trends
Pharmacol Sci. 2005 Oct;26(10):517-25. Review. Department of Pharmacology, University of Sassari Medical School, Sassari, Sardinia, Italy. biancamarchetti@libero.it A sustained inflammatory reaction is present in acute (e.g. stroke) and chronic (e.g. Alzheimer's disease, Parkinson's disease and multiple sclerosis) neurodegenerative disorders. Inflammation, which is fostered by both residential glial cells and blood-circulating cells that infiltrate the diseased brain, probably starts as a time- and site-specific defense mechanism that could later evolve into a destructive and uncontrolled reaction. In this article, we review the crucial dichotomy of brain inflammation, where failure to resolve an acute beneficial response could lead to a vicious and anarchic state of chronic activation. The possible use of non-steroidal anti-inflammatory drugs for the management of neurode- generative diseases is discussed in light of recent data demonstrating a neuroprotective role of local innate and adaptive immune responses. Novel therapeutic approaches must rely on potentiation of endogenous anti-inflammatory pathways, identification of early markers of neuronal deterioration and a combination treatment involving immune modulation and anti-inflammatory therapies.3. |
5. |
McIver CJ, Jacques CF, Chow SS, Munro SC, Scott GM, Roberts JA, Craig ME,
Rawlinson WD. Development of multiplex PCRs for detection of common viral
pathogens and agents of congenital infections. J Clin Microbiol. 2005
Oct;43(10):5102-10.
Department of Microbiology, South Eastern Area Laboratory Service,
Prince of Wales Hospital, New South Wales 2031, Australia. Potential causes of congenital infection include Toxoplasma gondii and viruses such as cytome- galovirus (CMV), enterovirus, hepatitis C virus, herpes simplex virus types 1 and 2 (HSV-1 and -2), human herpesvirus types 6, 7, and 8, lymphocytic choriomeningitis virus, parvovirus, rubella virus, and varicella-zoster virus. Testing for each of these agents using nucleic acid tests is time consuming and the availability of clinical samples such as amniotic fluid or neonatal blood is often limited. The aim of this study was to develop multiplex PCRs (mPCRs) for detection of DNA and RNA agents in the investigation of congenital infection and an mPCR for the viruses most commonly requested in a diagnostic virology laboratory (CMV, Epstein-Barr virus, enterovirus, HSV-1, HSV-2, and varicella-zoster virus). The assays were assessed using known pathogen-positive tissues (cultures, placentae, plasma, and amniotic fluid) and limits of detection were determined for all the agents studied using serial dilutions of plasmid targets. Nested PCR was performed as the most sensitive assay currently available, and detection of the amplicons using hybridization to labeled probes and enzyme-linked immunosorbent assay detection was incorporated into three of the four assays. This allowed detection of 10 to 10(2) copies of each agent in the samples processed. In several patients, an unexpected infection was diagnosed, including a case of encephalitis where HSV was the initial clinical suspicion but CMV was detected. In the majority of these cases the alternative agent could be confirmed using reference culture, serology, or fluorescence methods and was of relevance to clinical care of the patient. The methods described here provide useful techniques for diagnosing congenital infections and a paradigm for assessment of new multiplex PCRs for use in the diagnostic laboratory |
Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics: |
13768.
Chanama S, Sukprasert W, Sa-ngasang A, A-nuegoonpipat A,
Sangkitporn S, Kurane I, Anantapreecha S. Detection of Japanese
encephalitis (JE) virus-specific IgM in cerebrospinal fluid and serum
samples from JE patients. Jpn J Infect Dis. 2005 Oct;58(5):294-6. 13769.
Lee DH, Mathew J, Pfahler W, Ma D, Valinsky J, Prince AM, Andrus
L. Individual donor nucleic acid amplification testing for detection of
West Nile virus. J Clin Microbiol. 2005 Oct;43(10):5111-6. 13770.
Lolli F, Mazzanti B, Pazzagli M, Peroni E, Alcaro MC, Sabatino G,
Lanzillo R, Brescia Morra V, Santoro L, Gasperini C, Galgani S, D'Elios
MM, Zipoli V, Sotgiu S, Pugliatti M, Rovero P, Chelli M, Papini AM. The
glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis.
J Neuroimmunol. 2005 Oct;167(1-2):131-7. 13771.
Marciniak C, Rosenfeld EL. Serial electrodiagnostic studies in
West Nile virus-associated acute flaccid paralysis. Am J Phys Med
Rehabil. 2005 Nov;84(11):904-10. 13772.
Pawar SD, Singh A, Gangodkar SV, Rao BL. Propagation of
Chandipura virus in chick embryos. Indian J Exp Biol. 2005
Oct;43(10):930-2. 13773.
Rand K, Houck H, Lawrence R. Real-time polymerase chain reaction
detection of herpes simplex virus in cerebrospinal fluid and cost
savings from earlier hospital discharge. J Mol Diagn. 2005
Oct;7(4):511-6. Pathogenesis: 13774.
Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS,
Boer E, Wolfinbarger JB, Bloom ME. Inhibition of interferon-stimulated
JAK-STAT signaling by a tick-borne flavivirus and identification of NS5
as an interferon antagonist. J Virol. 2005 Oct;79(20):12828-39. 13775.
Briese T, Bernard KA. West Nile virus--an old virus learning new
tricks? J Neurovirol. 2005 Oct;11(5):469-75. Review. 13776.
Chatterjee P. Japanese encephalitis outbreak in India. Lancet
Neurol. 2005 Nov;4(11):700. 13777.
Cruz-Pacheco G, Esteva L, Montano-Hirose JA, Vargas C. Modelling
the dynamics of West Nile Virus. Bull Math Biol. 2005 Nov;67(6):1157-72.
13778.
Custer B, Busch MP, Marfin AA, Petersen LR. The
cost-effectiveness of screening the U.S. blood supply for West Nile
virus. Ann Intern Med. 2005 Oct 4;143(7):486-92. Summary for patients
in: Ann Intern Med. 2005 Oct 4;143(7):I44. 13779.
Hanna SL, Pierson TC, Sanchez MD, Ahmed AA, Murtadha MM, Doms RW.
N-linked glycosylation of west nile virus envelope proteins influences
particle assembly and infectivity. J Virol. 2005 Nov;79(21):13262-74. 13780.
Lee DH, Mathew J, Pfahler W, Ma D, Valinsky J, Prince AM, Andrus
L. Individual donor nucleic acid amplification testing for detection of
West Nile virus. J Clin Microbiol. 2005 Oct;43(10):5111-6. 13781.
Olival KJ, Daszak P. The ecology of emerging neurotropic viruses.
J Neurovirol. 2005 Oct;11(5):441-6. Review. 13782.
Ota MO, Moss WJ, Griffin DE. Emerging diseases: measles. J
Neurovirol. 2005 Oct;11(5):447-54. Review. 13783.
Soldan SS, Gonzalez-Scarano F. Emerging infectious diseases: the
Bunyaviridae. J Neurovirol. 2005 Oct;11(5):412-23. Review. Vaccines: 13784.
Hombach J, Solomon T, Kurane I, Jacobson J, Wood D. Report on a
WHO consultation on immunological endpoints for evaluation of new
Japanese encephalitis vaccines, WHO, Geneva, 2-3 September, 2004.
Vaccine. 2005 Nov 1;23(45):5205-11. 13785.
Marfin AA, Gubler DJ. Japanese encephalitis: the need for a more
effective vaccine. Lancet. 2005 Oct 15-21;366(9494):1335-7. 13786.
Ohrr H, Tandan JB, Sohn YM, Shin SH, Pradhan DP, Halstead SB.
Effect of single dose of SA 14-14-2 vaccine 1 year after immunisation in
Nepalese children with Japanese encephalitis: a case-control study.
Lancet. 2005 Oct 15-21;366(9494):1375-8. 13787.
Pugachev KV, Guirakhoo F, Monath TP. New developments in
flavivirus vaccines with special attention to yellow fever. Curr Opin
Infect Dis. 2005 Oct;18(5):387-94. Review.
13788.
Sejvar JJ, Labutta RJ, Chapman LE, Grabenstein JD, Iskander J,
Lane JM. Neurologic adverse
events associated with smallpox vaccination in the United States,
2002-2004. JAMA. 2005 Dec 7;294(21):2744-50. Erratum in: JAMA. 2005 Dec
28;294(24):3092. 13789.
Zenz W, Pansi H, Zoehrer B, Mutz I, Holzmann H, Kraigher A,
Berghold A, Spork D. Tick-borne
encephalitis in children in Styria and Slovenia between 1980 and 2003.
Pediatr Infect Dis J. 2005 Oct;24(10):892-6. Therapy: 13790.
Hanly JG, Harrison MJ. Management of neuropsychiatric lupus. Best
Pract Res Clin Rheumatol. 2005 Oct;19(5):799-821. Review. 13791.
Openshaw H, Cantin EM. Corticosteroids in herpes simplex virus
encephalitis. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1469.
13792. RamachandranNair R, Parameswaran M, Girija AS. Acute disseminated encephalomyelitis treated with plasmapheresis. Singapore Med J. 2005 Oct;46(10):561-3. |
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July
2006 Some Selected Abstracts: |
|
1. |
Centers for Disease Control and Prevention (CDC). Human rabies--Mississippi, 2005. MMWR Morb Mortal Wkly Rep. 2006 Mar 3;55(8):207-8. On September 27, 2005, a previously
healthy boy aged 10 years in Mississippi died from encephalitis later
attributed to rabies. This report summarizes the patient's clinical course
and the subsequent epidemiologic investigation, which implicated exposure
to bats at the boy's home as the likely source of rabies. The findings
underscore the importance of |
Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics: |
14319. Civen R, Villacorte F, Robles DT, Dassey DE, Croker C, Borenstein L, Harvey SM, Mascola L. West Nile virus infection in the pediatric population. Pediatr Infect Dis J. 2006 Jan;25(1):75-8. 14320. Gunduz A, Beskardes AF, Kutlu A, Ozkara C, Karaagac N, Yeni SN. Herpes encephalitis as a cause of nonconvulsive status epilepticus. Epileptic Disord. 2006 Mar;8(1):57-60. 14321. Mort DJ, Bronstein AM. Sudden deafness. Curr Opin Neurol. 2006 Feb;19(1):1-3. 14322. Sharma V, Chan YC, Ong, Teoh HL, Wilder-Smith EP. Bickerstaff's brainstem encephalitis: can it recur? J Clin Neurosci. 2006 Feb;13(2):277-9. 14323. Wang
DS, Tang Y, Wang Y. A case of overlapping Bickerstaff's brainstem
encephalitis and Guillain-Barre syndrome. J Zhejiang Univ Sci B. 2006
Feb;7(2):138-41. Pathogenesis: 14324. Hsu YH, Cho LC, Wang LS, Chen LK, Lee JJ, Yang HH. Acute respiratory distress syndrome associated with rabies: a case report. Kaohsiung J Med Sci. 2006 Feb;22(2):94-8. |
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October 2006
Some selected abstract: |
|
1 |
Clarke M, Newton RW,
Klapper PE, Sutcliffe H, Laing I, Wallace G. Childhood encephalopathy:
viruses, immune response, and outcome. Dev Med Child Neurol. 2006
Apr;48(4):294-300. |
2 |
Keogh JM, Badawi N. The
origins of cerebral palsy. Curr Opin Neurol. 2006 Apr;19(2):129-34. Review.
|
Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics: 14704. Dutta A, Tonkin T, Gelman W. Postpartum convulsions--a diagnostic enigma. J R Soc Med. 2006 Apr;99(4):203-4. 14705. Merkler D, Horvath E, Bruck W, Zinkernagel RM, Del la Torre JC, Pinschewer DD. "Viral deja vu" elicits organ-specific immune disease independent of reactivity to self. J Clin Invest. 2006 May;116(5):1254-63. Pathogenesis: 14706. Anlar B, Waye JS, Eng B, Oguz KK. Atypical clinical course in juvenile metachromatic leukodystrophy involving novel arylsulfatase A gene mutations. Dev Med Child Neurol. 2006 May;48(5):383-7. Therapy: 14707. Clarke M, Newton RW, Klapper PE, Sutcliffe H, Laing I, Wallace G. Childhood encephalopathy: viruses, immune response, and outcome. Dev Med Child Neurol. 2006 Apr;48(4):294-300. 14708. Keogh JM, Badawi N. The origins of cerebral palsy. Curr Opin Neurol. 2006 Apr;19(2):129-34. Review |
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