January 2006

Some Selected Abstracts:


Bush A.How has research in the last five years changed my clinical practice? Arch Dis Child. 2005 Aug;90(8):832-6.

Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

He first instruction to examination candidates is to read and answer the question actually set. Doing so in this case leads to the following CONCLUSIONS: how research has changed my clinical practice includes the act of doing research, as well as reading about the work of others. Thus, this article refers to my own clinical practice (tertiary referral paediatric respiratory medicine in a setting where we do not service an accident and emergency department), rather than that of others. This means excluding important conditions such as acute croup and uncomplicated community acquired pneumonia. I should write about what has changed my practice, not what other people think I ought to have changed. So this will be a personal view, limited to research published in a peer review format at the time of writing. I shall also assume that change is an ongoing process, so I shall include change in progress, provided it is supported by published literature.


Cantani A, Micera M Neonatal cow milk sensitization in 143 case-reports: role of early exposure to cow's milk formula. Eur Rev Med Pharmacol Sci. 2005 Jul-Aug;9(4):227-30.

Department of Pediatrics, Allergy and Clinical Immunology Division, La Sapienza University--Rome, Italy.

OBJECTIVE: Cow's milk (CM) allergy (CMA) is a disease of infancy, usually appearing in the first months of life. Symptoms triggered by CM at first introduction are not completely defined. The evaluation of infants for possible CMA is one of the more common problems encountered by pediatricians. Purpose of this study was to investigate the prevalence of severe reaction to CM and clinical manifestation triggered by CM administration in the nurseries. MATERIALS AND METHODS: The series includes 143 prospectively studied CM-allergic babies. RESULTS: At the first introduction of CM, at the age of 1-8 months (median 4 months) all infants had immediate symptoms The babies were probably sensitized during the first days of life. Particularly sensitizing appears to be the exposure to CM formulas in the neonatal nursery. DISCUSSION: Little doses of allergens are more sensitizing than larger ones. We provide clear evidence of the immunological effects of oral antigen administration during the neonatal period, and discuss the possible critical allergen transmission to the nursing baby via breast milk (BM).


Chinen J, Shearer WT. Basic and clinical immunology. J Allergy Clin Immunol. 2005 Aug;116(2):411-8.

Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

The authors selected articles published in the literature from January 2004 through December 2004 that were relevant to the areas of basic and clinical immunology. Several articles explored the development of TH1 or TH2 response and the role of the monocyte-T cell interaction. Others were articles describing the action of drugs commonly used in asthma to inhibit cytokine responses and the anti-inflammatory role of nonimmune pulmonary cells present in the lung. Several reports show how dendritic cells are being developed as vehicles for DNA vaccines aimed at stimulating cellular responses, an advance of great importance for HIV researchers working on vaccines, who are concerned about the different ways HIV evades the immune response. Other publications described Toll-like receptors in diverse cells, including mast cells and CD4+ T cells, for the recognition of viruses and bacteria. In the area of clinical immunology, an updated classification for primary immunodeficiencies with more than 100 identified genes responsible for these diseases and the report on the second clinical trial of gene therapy for X-linked severe combined immunodeficiency syndrome were published. Significant advances included the clinical prognosis in common variable immunodeficiency for patients presenting with lung pathology, the safety of live vaccines in partial DiGeorge syndrome, the report of patients with complete DiGeorge syndrome with the presence of peripheral blood T cells, the clinical spectrum of patients with NF-kappaB essential modifier (NEMO) gene deficiency, the publication of a consensus algorithm for the management of hereditary angioedema, and the report of immune restoration syndrome in pediatric HIV infection.


Ingram P, Lavery I. Peripheral intravenous therapy: key risks and implications for practice. Nurs Stand. 2005 Jul 27-Aug 2;19(46):55-64; quiz 66.

Personnel, environment and procedures related to peripheral intravenous (IV) therapy are explained. Parenteral routes are suggested and, where peripheral IV therapy is required, recommendations are made to minimize risk of anaphylaxis and infection.


Kimata H. Brain-derived neurotrophic factor selectively enhances allergen-specific IgE production. Neuropeptides. 2005 Aug;39(4):379-83

Department of Allergy, Satou Hospital, 65-1, Yabuhigashimachi, Hirakata-City, Osaka Prefecture 573-1124, Japan.

We studied the effect of brain-derived neurotrophic factor (BDNF) on in vitro Japanese cedar pollen (JCP)-specific IgE production by mononuclear cells from atopic keratoconjunctivitis patients with JCP allergy. BDNF enhanced JCP-specific IgE production in a dose-dependent fashion in cultures of mononuclear cells stimulated with JCP, and maximal enhancement was achieved at 10 ng/ml. In contrast, BDNF had no effect on JCP-specific IgA or IgG4 production. On the other hand, other neurotrophins, NGF, NT-3, or NGF failed to enhance JCP-specific IgE production. Moreover, anti-BDNF mAb specifically blocked BDNF-induced enhancement of JCP-specific IgE production. Study for cytokine production revealed that BDNF decreased production of Th1 cytokines, IFN-gamma and IL-12, while it had no effect on production of TH2 cytokines, IL-4, IL-10 and IL-13, in cultures of mononuclear cells stimulated with JCP. These results indicate that BDNF relatively skews cytokine pattern toward Th2 type. Collectively, BDNF may increase allergen-specific IgE production, which may in turn aggravate allergic symptoms.


Kwah YC, Leow YH.Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman. Singapore Med J. 2005 Jul;46(7):349-51.

National Skin Centre, 1 Mandalay Road, Singapore 308205.

Acute generalised exanthematous pustulosis (AGEP) is an adverse drug reaction that can occur in any age group. It is commonly mistaken as pustular psoriasis or cutaneous infection, resulting in unnecessary commencement of medications such as methotrexate and antibiotics that can cause harm to the patient or interact and adversely affect the efficacy of other medications. Early diagnosis of AGEP avoids unnecessary investigations and treatment, which not only can harm the patient but also escalate health care, as the condition is self-limiting. This case report illustrates AGEP secondary to Cefaclor occurring in a 72-year-old Chinese woman. Although the literature has documented the occurrence of AGEP with Cefaclor, the unique feature of this case is the occurrence of AGEP following repeated uneventful courses of Cefaclor. This case highlights that AGEP must never be forgotten in the work-up for pustular eruptions in an elderly patient.


Shek LP, Bardina L, Castro R, Sampson HA, Beyer K Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy. 2005       Jul;60(7):912-9.

Division of Pediatric Allergy and Immunology and The Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

BACKGROUND: Cow milk allergy (CMA) is one of the most common food allergies in childhood. Patients with CMA present with a wide range of immunoglobulin (Ig)E- and non-IgE-mediated clinical syndromes. Limited information is known about the specific humoral and cellular responses to cow milk proteins in these various forms of CMA. OBJECTIVE: The aim of the study was to determine IgE, IgA, IgG1 and IgG4 antibody levels and lymphocyte proliferative responses to the major cow milk allergens in patients with IgE- and non-IgE-mediated CMA. METHODS: One hundred and forty cow milk allergic patients, 6 months to 22 years of age, were included in the study. One hundred and thirteen patients had IgE-mediated CMA, 11 had milk protein-induced enterocolitis syndrome and 16 had allergic eosinophilic gastroenteritis. Twenty-one patients without food allergy, 8 months to 18 years of age, served as controls. Serum IgE, IgA, IgG1 and IgG4 antibodies to alpha-, beta-, and kappa-casein, alpha-lactalbumin and beta-lactoglobulin were measured using enzyme-linked immunosorbent assays. For a subset of these patients, we performed lymphocyte proliferation assays to the various milk allergens. RESULTS: Patients with IgE-mediated CMA had higher specific IgE concentrations to casein compared with whey proteins (P < 0.001). In this group of patients, there was a positive correlation between IgE levels and levels of the other isotypes for all four milk proteins (P < 0.001). In general, the caseins were the more allergenic and antigenic proteins in all groups of patients. Patients with enterocolitis syndrome produced less milk protein-specific IgG4 (P < 0.05) and had a trend for higher IgA antibody levels when compared to the control group. Lymphocyte proliferative responses in all groups with CMA were significantly higher than controls (P < 0.05), although this response was similar in patients with IgE- and non-IgE-mediated CMA. CONCLUSION: There is a distinct pattern of humoral antibody response in the different forms of CMA. Patients with IgE-mediated CMA have an elevated polyisotypic response to cow milk protein. The relative lack of specific IgG4 production in patients with enterocolitis syndrome may be involved in the pathogenesis of the disease. In general, caseins appear to be the predominant allergen in patients with CMA.


Yen ZS, Chen SC.Best evidence topic report. Nebulised furosemide in acute adult asthma. Emerg Med J. 2005 Sep;22(9):654-5.

Department of Emergency Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.

A short cut review was carried out to establish whether the addition of nebulised furosemide to beta-agonist therapy improves outcomes in acute asthma. Altogether 87 papers were found using the reported search, of which two presented the best evidence to answer the clinical question. A further relevant paper was found on scanning the references of these papers. The author, date and country of origin, patient group studied, study type, relevant outcome, results, and study weaknesses of the best papers are tabulated. There is currently insufficient evidence to support the routine addition of nebulised furosemide to standard beta agonist therapy in acute asthma in adults.

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

13122.  Boyd R, Stuart P. Pressurised metered dose inhalers with spacers versus nebulisers for beta-agonist delivery in acute asthma in children in the emergency department. Emerg Med J. 2005 Sep;22(9):641-2.

13123.  Bozkurt B, Karakaya G, Kalyoncu AF. Seasonal rhinitis, clinical characteristics and risk factors for asthma. Int Arch Allergy Immunol. 2005 Sep;138(1):73-9.

13124.  Bustos P, Amigo H, Oyarzun M, Rona RJ. Is there a causal relation between obesity and asthma? Evidence from Chile. Int J Obes (Lond). 2005 Jul;29(7):804-9.

13125.  Cotton D. Asthma and invasive pneumococcal disease. N Engl J Med. 2005 Aug 18;353(7):738-9; author reply 738-9.

13126.  de Jong PA, Muller NL, Pare PD, Coxson HO. Computed tomographic imaging of the airways: relationship to structure and function. Eur Respir J. 2005 Jul;26(1):140-52. Review.

13127.   Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol. 2005 Aug;116(2):267-73.

13128.  Gabrielli M, Candelli M, Cremonini F, Ojetti V, Santarelli L, Nista EC, Nucera E, Schiavino D, Patriarca G, Gasbarrini G, Pola P, Gasbarrini A. Idiopathic chronic urticaria and celiac disease. Dig Dis Sci. 2005 Sep;50(9):1702-4.

13129.  Gangur V, Kelly C, Navuluri L. Sesame allergy: a growing food allergy of global proportions? Ann Allergy Asthma Immunol. 2005 Jul;95(1):4-11; quiz 11-3, 44. Review.

13130.  Goetz DW, Whisman BA, Goetz AD. Cross-reactivity among edible nuts: double immunodiffusion, crossed immunoelectrophoresis, and human specific igE serologic surveys. Ann Allergy Asthma Immunol. 2005 Jul;95(1):45-52.

13131.  Gompels MM, Lock RJ. C1 inhibitor deficiency: diagnosis. Clin Exp Dermatol. 2005 Jul;30(4):460-2. Review.

13132.  Gupta A. T-cells and B-cells in bronchial asthma. Acta Ciene Indica-Chem 2003,29(3), 223-5.

13133.   Helms PJ. Exercise induced asthma: real or imagined? Arch Dis Child. 2005 Sep;90(9):886-7. Review.

13134.   Kamath AV, Pavord ID, Ruparelia PR, Chilvers ER. Is the neutrophil the key effector cell in severe asthma? Thorax. 2005 Jul;60(7):529-30.

13135.  Kwah YC, Leow YH. Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman. Singapore Med J. 2005 Jul;46(7):349-51.

13136.  Lepper PM, Koenig W, Moller P, Perner S. A case of sudden cardiac death due to isolated eosinophilic coronary arteritis. Chest. 2005 Aug;128(2):1047-50.

13137.   Mainali ES, Kikuchi T, Tew JG. Dexamethasone inhibits maturation and alters function of monocyte-derived dendritic cells from cord blood. Pediatr Res. 2005 Jul;58(1):125-31.

13138.  Martelli A, Bouygue GR, Isoardi P, Marelli O, Sarratud T, Fiocchi A. Oral food challenges in children in Italy. Allergy. 2005 Jul;60(7):907-11.

13139.  McKeown PF, Walsh SJ, Menown IB. Images in cardiology: An unusual case of right ventricular dilatation. Heart. 2005 Sep;91(9):1147.

13140.  Oertel MF, Korinth MC, Reinges MH, Gilsbach JM. Pneumorrhachis of the entire spinal canal. J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):1036.

13141.  Oh SW, Lew W. Erythema multiforme induced by acetaminophen: a recurrence at distant sites following patch testing. Contact Dermatitis. 2005 Jul;53(1):56-7.

13142.   Paquet P, Jacob E, Pierard GE. Cystic lesion of the parotid following drug-induced toxic epidermal necrolysis (Lyell's syndrome). J Oral Pathol Med. 2005 Jul;34(6):380-2.

13143.  Saxena S, Joshi JM. Multiple pulmonary nodules. Indian J Chest Dis Allied Sci. 2005 Jul-Sep;47(3):193-5.

13144.   Seear M, Wensley D, West N. How accurate is the diagnosis of exercise induced asthma among Vancouver schoolchildren? Arch Dis Child. 2005 Sep;90(9):898-902.

13145   Yasui K, Kobayashi N, Yamazaki T, Koike K, Fukushima K, Taniuchi S, Kobayashi Y. Neutrophilic inflammation in childhood bronchial asthma. Thorax. 2005 Aug;60(8):704-5.



13146.    Cantani A, Micera M. Neonatal cow milk sensitization in 143 case-reports: role of early exposure to cow's milk formula. Eur Rev Med Pharmacol Sci. 2005 Jul-Aug;9(4):227-30.

13147.  Cavarape A, Quinkenstein E, Pizzolitto S, Soardo G, Sechi L.  Henoch-Schonlein purpura in a patient with diabetic nephropathy and vascular complications. Nephrol Dial Transplant. 2005 Jul;20(7):1514-5.

13148.  Cruz AA. The 'united airways' require an holistic approach to management. Allergy. 2005 Jul;60(7):871-4.

13149.  Cuzzocrea S. Shock, inflammation and PARP. Pharmacol Res. 2005 Jul;52(1):72-82. Review.

13150.  Kalman S, Ibrahim Aydin H, Atay A. Henoch-Schonlein purpura in a child following varicella. J Trop Pediatr. 2005 Aug;51(4):240-1.

13151.  Kimata H. Brain-derived neurotrophic factor selectively enhances allergen-specific IgE production. Neuropeptides. 2005 Aug;39(4):379-83.

13152.  Lin S, Reibman J, Bowers JA, Hwang SA, Hoerning A, Gomez MI, Fitzgerald EF.  Upper respiratory symptoms and other health effects among residents living near the World Trade Center site after September 11, 2001. Am J Epidemiol. 2005 Sep 15;162(6):499-507.

13153.  McMillan JJ. Fungus sensitivity as a cause of Meniere's disease? Arch Otolaryngol Head Neck Surg. 2005 Sep;131(9):830.

13154.  Mills EN, Breiteneder H.  Food allergy and its relevance to industrial food proteins. Biotechnol Adv. 2005 Sep;23(6):409-14. Review.

13155.  Rees J. ABC of asthma. Prevalence. BMJ. 2005 Aug 20;331(7514):443-5. Review.

13156.    Shek LP, Bardina L, Castro R, Sampson HA, Beyer K. Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy. 2005 Jul;60(7):912-9.

13157.  Skorge TD, Eagan TM, Eide GE, Gulsvik A, Bakke PS.  The adult incidence of asthma and respiratory symptoms by passive smoking in uterus or in childhood. Am J Respir Crit Care Med. 2005 Jul 1;172(1):61-6.

13158.  Theoharides TC, Donelan J, Kandere-Grzybowska K, Konstantinidou A. The role of mast cells in migraine pathophysiology. Brain Res Brain Res Rev. 2005 Jul;49(1):65-76. Review.

13159.  Vercelli D. Genetic regulation of IgE responses: Achilles and the tortoise. J Allergy Clin Immunol. 2005 Jul;116(1):60-4. Review.

13160.  Yacoub MR, Lemiere C, Malo JL. Asthma caused by cyanoacrylate used in a leisure activity. J Allergy Clin Immunol. 2005 Aug;116(2):462.


13161.  Chinen J, Shearer WT. Basic and clinical immunology. J Allergy Clin Immunol. 2005 Aug;116(2):411-8. Review.

13162.  Donnelly JJ, Wahren B, Liu MA.   DNA vaccines: progress and challenges. J Immunol. 2005 Jul 15;175(2):633-9. Review.

13163.  Kinet JP. A new strategy to counter allergy. N Engl J Med. 2005 Jul 21;353(3):310-2.

13164.  Saxton JG. Do we truly understand vaccine reactions and vaccinosis? Homeopathy. 2005 Jul;94(3):200-1. Review.


13165.   Aitkenhead AR. Injuries associated with anaesthesia. A global perspective. Br J Anaesth. 2005 Jul;95(1):95-109.

13166. Altman KW, Stephens RM, Lyttle CS, Weiss KB. Changing impact of gastroesophageal reflux in medical and otolaryngology practice. Laryngoscope. 2005 Jul;115(7):1145-53.

13167.  Arshad SH. Primary prevention of asthma and allergy. J Allergy Clin Immunol. 2005 Jul;116(1):3-14; quiz 15. Review.

13168.  Atherton D. Maintaining healthy skin in infancy using prevention of irritant napkin dermatitis as a model. Community Pract. 2005 Jul;78(7):255-7. Review.

13169.  Bailie GR, Clark JA, Lane CE, Lane PL. Hypersensitivity reactions and deaths associated with intravenous iron preparations. Nephrol Dial Transplant. 2005 Jul;20(7):1443-9.

13170.  Barnard A. Management of an acute asthma attack. Aust Fam Physician. 2005 Jul;34(7):531-4. Review. Erratum in: Aust Fam Physician. 2005 Aug;34(8):616.

13171.  Bayraktar MR, Mehmet N, Durmaz R. Serum cytokine changes in Turkish children infected with Giardia lamblia with and without allergy: Effect of metronidazole treatment. Acta Trop. 2005 Aug;95(2):116-22.

13172.  Bush A. How has research in the last five years changed my clinical practice? Arch Dis Child. 2005 Aug;90(8):832-6. Review.

13173.  Cady RK, Dodick DW, Levine HL, Schreiber CP, Eross EJ, Setzen M, Blumenthal HJ, Lumry WR, Berman GD, Durham PL. Sinus headache: a neurology, otolaryngology, allergy, and primary care consensus on diagnosis and treatment. Mayo Clin Proc. 2005 Jul;80(7):908-16. Review.

13174.  Currie GP, Anderson WJ, Lee DK. Effects of montelukast in patients with persistent asthma using inhaled corticosteroids plus additional second-line therapy. J Allergy Clin Immunol. 2005 Jul;116(1):230.

13175.  Currie GP, Devereux GS. Surgery for difficult persistent asthma. Thorax. 2005 Aug;60(8):706.

13176.  Dewachter P, Mouton-Faivre C, Trechot P, Lleu JC, Mertes PM. Severe anaphylactic shock with methylene blue instillation. Anesth Analg. 2005 Jul;101(1):149-50.

13177.  Gluck PA, Gluck JC. A review of pregnancy outcomes after exposure to orally inhaled or intranasal budesonide. Curr Med Res Opin. 2005 Jul;21(7):1075-84. Review.

13178.  Hepner DL. From the laboratory to the bedside: searching for an understanding of anaphylaxis. Anesthesiology. 2005 Jul;103(1):1-2.

13179.  Hon KL, Leung TF, Wong Y, So HK, Li AM, Fok TF. A survey of bathing and showering practices in children with atopic eczema. Clin Exp Dermatol. 2005 Jul;30(4):351-4.

13180.  Hughes MA, Parisi M, Grossman S, Kleinberg L. Primary brain tumors treated with steroids and radiotherapy: low CD4 counts and risk of infection. Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1423-6.

13181.  Ingram P, Lavery I. Peripheral intravenous therapy: key risks and implications for practice. Nurs Stand. 2005 Jul 27-Aug 2;19(46):55-64; quiz 66. Review.

13182.  Iqbal H, Evans A. Dapsone therapy for Henoch-Schonlein purpura: a case series. Arch Dis Child. 2005 Sep;90(9):985-6.

13183. Kankaanranta H, Moilanen E, Zhang X. Pharmacological regulation of human eosinophil apoptosis. Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):433-45. Review.

13184.  Kostis JB, Kim HJ, Rusnak J, Casale T, Kaplan A, Corren J, Levy E. Incidence and characteristics of angioedema associated with enalapril. Arch Intern Med. 2005 Jul 25;165(14):1637-42. 

13185.  MacDonald A, Forsyth A. Nutritional deficiencies and the skin. Clin Exp Dermatol. 2005 Jul;30(4):388-90.

13186.  Murch SH. Probiotics as mainstream allergy therapy? Arch Dis Child. 2005 Sep;90(9):881-2.

13187.  Murphy E, Martin S, Patterson JV. Developing practice guidelines for the administration of intravenous immunoglobulin. J Infus Nurs. 2005 Jul-Aug;28(4):265-72. Review.

13188.  Rees J. Methods of delivering drugs. BMJ. 2005 Sep 3;331(7515):504-6. Review.

13189.  Rodrigo GJ, Castro-Rodriguez JA. Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax. 2005 Sep;60(9):740-6.

13190.  Rogovik AL, Goldman RD. Treating infants' colic. Can Fam Physician. 2005 Sep;51:1209-11. Review.

13191.  Sheikh A, Walker S. Anaphylaxis. BMJ. 2005 Aug 6;331(7512):330. Review.

13192.  Yen ZS, Chen SC. Best evidence topic report. Nebulised furosemide in acute adult asthma. Emerg Med J. 2005 Sep;22(9):654-5. Review.




April 2006

Some Selected Abstracts:


Aghayev E, Yen K, Sonnenschein M, Jackowski C, Thali M, Vock P, Dirnhofer  R.Pneumomediastinum and soft tissue emphysema of the neck in postmortem CT and MRI; a new vital sign in hanging? Forensic Sci Int. 2005 Oct 29;153(2-3):181-8.

Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland.

Spontaneous pneumomediastinum commonly occurs in healthy young men or parturient women in whom an increased intra-alveolar pressure (Valsalva maneuver, asthma, cough, emesis) leads to the rupture of the marginal pulmonary alveoli. The air ascends along the bronchi to the mediastinum and the subcutaneous space of the neck, causing cervico-fascial subcutaneous emphysema in 70-90% of cases. Ninety-five forensic cases, including five cases of hanging, were examined using postmortem multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) prior to autopsy until December 2003. This paper describes the findings of pneumomediastinum and cervical emphysema in three of five cases of hanging. The mechanism of its formation is discussed based on these results and a review of the literature. In conclusion, when putrefaction gas can be excluded the findings of pneumomediastinum  and cervical soft tissue emphysema serve as evidence of vitality of a hanged person. Postmortem cross-sectional imaging is considered a useful visualization tool for emphysema, with a great potential for examination and documentation.


Arora R, Gal TJ, Hagan LL. An unusual case of laryngomalacia presenting as asthma refractory to therapy. Ann Allergy Asthma Immunol. 2005 Dec;95(6):607-11.

Department of Allergy/Immunology, Wilford Hall Medical Center, Lackland AFB, Texas 78236-5300, USA.

BACKGROUND: Laryngomalacia is the most common cause of stridor in infants, but few reports exist of clinically relevant laryngomalacia in adults. OBJECTIVE: To present and discuss an unusual late presentation of laryngomalacia and its significance in the evaluation and management of asthma. METHODS: An 18-year-old woman presented to an academic medical center with symptoms of "wheezing" on inspiration and exertion, with relatively normal spirometric findings. She was clinically diagnosed as having asthma at the age of 13 years, but her symptoms were poorly controlled by maximal medical therapy. Further evaluation with rhinolaryngoscopy demonstrated laryngomalacia characterized by redundant soft tissue overlying the right arytenoid cartilage and aryepiglottic fold. RESULTS: The patient demonstrated positive bronchoprovocation, with a 33% decrease in forced expiratory volume in 1 second after the administration of histamine, 1 mg/mL. However, with the otolaryngology evaluation, it was determined that her laryngeal findings were clinically significant. She subsequently underwent operative laryngoscopy with carbon dioxide laser excision of the laryngeal abnormality, resulting in improvement in her symptoms and a marked decrease in her need for asthma medication. CONCLUSIONS: We report an unusual case of laryngomalacia presenting as asthma that was successfully treated with laser surgical excision. This case emphasizes the necessity of differentiating classic wheezing from stridor and upper airway obstruction.


Chu KA, Wu YC, Lin MH, Wang HC. Acupuncture resulting in immediate bronchodilating response in asthma patients. J Chin Med Assoc. 2005 Dec;68(12):591-4.

Division of Chest Medicine, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, ROC.

There are some encouraging results in the English literature that show acupuncture resulting in an immediate improvement in pulmonary function, but there are also studies that have not demonstrated any benefit. We present 3 patients with persistent asthma who experienced immediate bronchodilatation after acupuncture without the use of any short-acting bronchodilator. After needle stimulation on selected acupoints, clinical symptoms such as dyspnea and wheezing improved. Pulmonary function test showed immediate improvement in forced expiratory volume in 1 second (FEV1), more than 20% as compared with baseline FEV1. Pulmonary function returned to baseline within 4 hours after acupuncture in 2 patients. From our observations of these 3 asthma patients, acupuncture may improve clinical dyspnea symptoms and performance on pulmonary function tests. Further large-scale controlled studies should be conducted to determine the effectiveness of acupuncture in the treatment of asthma.  


Goodnight WH, Soper DE. Pneumonia in pregnancy. Crit Care Med. 2005 Oct;33   (10 Suppl): S390-7.

Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, SC, USA.

OBJECTIVE: Historically, pneumonia during pregnancy has been associated with increased morbidity and mortality compared with nonpregnant women. The goal of this article is to review current literature describing pneumonia in pregnancy. This review will identify maternal risk factors, potential complications, and prenatal outcomes associated with pneumonia and describe the contemporary management of the varied causes of pneumonia in pregnancy. RESULTS: Coexisting maternal disease, including asthma and anemia, increase the risk of contracting pneumonia in pregnancy. Neonatal effects of pneumonia in pregnancy include low birth weight and increased risk of preterm birth, and serious maternal complications include respiratory failure. Community-acquired pneumonia is the most common form of pneumonia in pregnancy, with Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae accounting for most identified bacterial organisms. Beta-lactam and macrolide antibiotics are considered safe in pregnancy and are effective for most community-acquired pneumonia in pregnancy. Viral respiratory infections, including varicella, influenza, and severe acute respiratory syndrome, can be associated with maternal pneumonia. Current antiviral and respiratory therapies can reduce maternal morbidity and mortality from viral pneumonia. Influenza vaccination can reduce the prevalence of respiratory hospitalizations among pregnant women during influenza season. Pneumocystis pneumonia continues to carry significant maternal risk to an immunocompromised population. Prevention and treatment of Pneumocystis pneumonia with trimethoprim / sulfamethoxazole is effective in reducing this risk. CONCLUSIONS: Prompt diagnosis and treatment with contemporary antimicrobial therapy and intensive care unit management of respiratory compromise has reduced the maternal morbidity and mortality due to pneumonia in pregnancy. Prevention with vaccination in at-risk populations may reduce the prevalence and severity of pneumonia in pregnant women.


Levin ME, Motala C, Lopata AL. Anaphylaxis in a milk-allergic child after ingestion of soy formula cross-contaminated with cow's milk protein. Pediatrics. 2005 Nov;116(5):1223-5.

Allergy Clinic, School of Child and Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

In this report we describe a 9-month-old boy with severe persistent asthma and documented cow's milk allergy (presented with eczema and severe systemic reactions) who had an anaphylactic reaction to a soy formula contaminated with cow's milk protein. Quantitative  enzyme-linked immunosorbent assay analysis revealed trace quantities of beta-lactoglobulin in the offending soy formula as well as the dry powder. The patient did not demonstrate clinical reactivity to soy protein (negative challenge, tolerated pure soy formula well). Cross-contamination of the offending soy formula was presumed to have occurred during food manufacturing. This case demonstrates that trace quantities of cow's milk protein can elicit severe systemic reactions in highly milk-allergic individuals. This infant ingested the equivalent of 0.4 mL of cow's milk from the soy formula as documented by an immunoassay for beta-lactoglobulin. This highlights the ease with which cross-contamination can occur during food processing and reinforces the need for better quality control.  


Meltzer DI. Complications of body piercing. Am Fam Physician. 2005 Nov 15;72(10):2029-34. Summary for patients in: Am Fam Physician. 2005 Nov 15;72(10):2035-6.

State University of New York at Stony Brook School of Medicine, Stony Brook, New York, USA.

The trend of body piercing at sites other than the earlobe has grown in popularity in the past decade. The tongue, lips, nose, eyebrows, nipples, navel, and genitals may be pierced. Complications of body piercing include local and systemic infections, poor cosmesis, and foreign body rejection. Swelling and tooth fracture are common problems after tongue piercing. Minor infections, allergic contact dermatitis, keloid formation, and traumatic tearing may occur after piercing of the earlobe. "High" ear piercing through the ear cartilage is associated with more serious infections and disfigurement. Fluoroquinolone antibiotics are advised for treatment of auricular perichondritis because of their antipseudomonal activity. Many complications from piercing are body-site-specific or related to the piercing technique used. Navel, nipple, and genital piercings often have prolonged healing times. Family physicians should be prepared to address complications of body piercing and provide accurate information to patients.  


Reid G, Kirjaivanen P. Taking probiotics during pregnancy. Are they useful therapy for mothers and  newborns?  Can Fam Physician. 2005 Nov;51:1477-9.

Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute.

QUESTION: Recently, several of my pregnant patients have asked me about using probiotics during pregnancy. Is there any evidence that these innocuous bacteria work effectively? ANSWER: An increasing body of evidence suggests that probiotics are effective for treating bacterial vaginosis and allergic reactions. Most probiotics available in Canada, however, are of dubious quality, and, for many claimed indications, there is no proof of effectiveness yet.  


Restrepo RD, Pettignano R, DeMeuse P. Halothane, an effective infrequently used drug, in the treatment of pediatric status asthmaticus: a case report. J Asthma. 2005 Oct;42(8):649-51.

Department of Cardiopulmonary Care Sciences, Georgia State University, and Division of Critical Care, Hughes Spalding Children's Hospital, Atlanta, Georgia, USA.

Asthma is the most common chronic disease of childhood. Despite a better understanding of the disease process and its management, status asthmaticus continues to be a life-threatening event. The use of volatile inhaled anesthetics is infrequently reported as adjunctive therapy to conventional treatment of this condition. We report the use of halothane in a mechanically ventilated pediatric patient with life-threatening status asthmaticus who was admitted to the pediatric intensive care unit (PICU) after failing to respond to standard medical therapy and noninvasive positive pressure ventilation. A 12-year-old African American male was seen in the emergency department and treated with intravenous corticosteroids, beta-agonist therapy. He deteriorated rapidly and required endotracheal intubation and mechanical ventilation. Two hours later, the patient developed an acute, severe respiratory acidosis (pH=6.97, PaCO2=171, PaO2=162, BE=1.7). Halothane was started at 2% by using the Siemens Servo 900C anesthesia ventilator. Improvement in both arterial blood gases and exhaled tidal volume were noted 30 minutes after initiation of the anesthetic gas. The patient remained on halothane for a total of 36 hours. No adverse effects associated with the use of halothane were noted. The patient was extubated to BiPAP 16/6, FiO2=0.30 at 68 hours and was discharged home 5 days later.  


Vegunta RK, Raso M, Pollock J, Misra S, Wallace LJ, Torres A Jr, Pearl RH. Biliary dyskinesia: the most common indication for cholecystectomy in children. Surgery. 2005 Oct;138(4):  726-31; discussion 731-3.

University of Illinois College of Medicine at Peoria, USA.

BACKGROUND: The purpose of this study is to examine the current indications for cholecystectomy in children and to evaluate the results after such surgery. METHODS: Retrospective analysis of 107 consecutive cholecystectomies performed in children at the Children's Hospital of Illinois between October 1998 and September 2003. Hospital medical charts and outpatient clinic charts were reviewed. Patients' families were contacted by telephone to obtain longer-term follow-up. Results were analyzed with SPSS 12.0 for Windows (SPSS Inc, Chicago, Ill). RESULTS: Biliary dyskinesia (BD) was the indication for surgery for 62 (58%) of the 107 children who underwent cholecystectomy during the study period. Gallbladder calculus (GC) disease was the next most common indication with 29 (27%) children. The duration of symptoms was longer for BD. The most common presenting symptom in both groups was abdominal pain. Food intolerance was reported by 45% of patients with BD, significantly higher than patients with GC. Mean length of stay after cholecystectomy was 17 hours and 45 hours for BD and GC, respectively. Short-term follow-up showed relief or improvement of symptoms in 85% of children with BD and in 97% with GC. There were no deaths. Two (1.9%) children of the total of 107 developed complications; both had intra-abdominal abscesses. Most patients had complete or considerable long-term improvement in symptoms. CONCLUSIONS: Biliary dyskinesia was the most common indication for cholecystectomy in children in our study. More than half of the surgeries were performed on an outpatient basis. Morbidity was minimal and mortality was zero. We had satisfactory short- and long-term symptom resolution with long-term patient satisfaction reaching 95%.

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

13661.   Armstrong PA, Pazona JF, Schaeffer AJ. Anaphylactoid reaction after retrograde pyelography   despite        

             preoperative steroid preparation. Urology. 2005 Oct;66(4):880.

13662.     Bangash SA, Bahna SL. Pediatric food allergy update. Curr Allergy Asthma Rep. 2005 Nov;5(6):437-44.

13663.       Becklake MR. Wheeze, asthma diagnosis and medication use in developing countries. Thorax. 2005 Nov;60(11):885-7.

13664.       Bernstein JA. Chronic urticaria: an evolving story. Isr Med Assoc J. 2005 Dec;7(12):774-7.

13665.  Berstad A, Arslan G, Lind R, Florvaag E. Food hypersensitivity-immunologic (peripheral) or cognitive (central) sensitisation? Psychoneuroendocrinology. 2005 Nov;30(10):983-9.

13666.     Buchvald F, Hermansen MN, Nielsen KG, Bisgaard H. Exhaled nitric oxide predicts exercise-induced bronchoconstriction in    asthmatic school children. Chest. 2005 Oct;128(4):1964-7.

13667.      Dauer EH, Freese DK, El-Youssef M, Thompson DM. Clinical characteristics of eosinophilic esophagitis in children. Ann Otol Rhinol   Laryngol. 2005 Nov;114(11):827-33.

13668.     David GL, Koh WP, Lee HP, Yu MC, London SJ. Childhood exposure to environmental tobacco smoke and chronic respiratory symptoms in non-smoking adults: the Singapore Chinese Health Study. Thorax. 2005 Dec;60(12):1052-8. 

13669.      Ferrario F, Rastaldi MP. Henoch-Schonlein nephritis. J Nephrol. 2005 Nov-Dec;18(6):637-41.

13670.     Fruhauf J, Weinke R, Pilger U, Kerl H, Mullegger RR. Soft tissue cervicofacial emphysema after dental treatment: report of 2 cases with emphasis on the differential diagnosis of angioedema. Arch Dermatol. 2005 Nov;141(11):1437-40.

13671.     Garcia-Careaga M Jr, Kerner JA Jr. Gastrointestinal manifestations of food allergies in pediatric patients. Nutr Clin Pract. 2005 Oct;20(5):526-35. Review.

13672.     Gomez Real F, Svanes C, Bjornsson EH, Franklin K, Gislason D, Gislason T, Gulsvik A, Janson C, Jogi R, Kiserud T, Norback D, Nystrom L, Toren K, Wentzel-Larsen T, Omenaas E. Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax. 2006 Jan;61(1):34-40. 

13673.     Hendeles L, Marshik PL, Ahrens R, Kifle Y, Shuster J. Response to nonprescription epinephrine inhaler during nocturnal asthma. Ann Allergy Asthma Immunol. 2005 Dec;95(6):530-4.

13674.     Jani M, Ogston S, Mukhopadhyay S. Annual increase in body mass index in children with asthma on higher doses of inhaled steroids. J Pediatr. 2005 Oct;147(4):549-51.

13675.      Jindal SK, Gupta D, Aggarwal AN, Agarwal R; World Health Organization; Government of India. Guidelines for management of  asthma at primary and secondary levels of health care in India (2005). Indian J Chest Dis Allied Sci. 2005 Oct-Dec;47(4):309-43. Review.

13676.     Karatzios C, Bratu I, Flageole H, McDonald J. Chest pain and pulmonary lesion in a child with asthma. Pediatr Infect Dis J. 2005 Nov;24(11):1026, 1031.

13677.     Kawai M, Nakashima M, Takaori S, Nakamura Y, Akamatsu K, Nakashima M, Miyamoto T. Pharmacodynamic equivalence study of CFC-free and CFC-containing procaterol hydrochloride metered-dose inhalers. Methods Find Exp Clin Pharmacol. 2005 Oct;27(8):555-8. 

13678.      Khan J. Eye know it's red. Lancet. 2005 Oct 29-Nov 4;366(9496):1583.

13679.     Kim CJ, Chung HY, Kim SY, Kim YO, Ryu SY, Kim JC, Chung JH. Acute appendicitis in Henoch-Schonlein purpura: a case report. J Korean Med Sci. 2005 Oct;20(5):899-900.

13680.     Kim IK, Phrampus E, Venkataraman S, Pitetti R, Saville A, Corcoran T, Gracely E, Funt N, Thompson A. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. 2005 Nov;116(5):1127-33.

13681.     Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I. Respirtory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. J Allergy Clin Immunol. 2005 Oct;116(4):805-11.

13682.     Kroigaard M, Garvey LH, Menne T, Husum B. Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing? Br J Anaesth. 2005 Oct;95(4):468-71. 

13683.     Lang DM.  Blocking aspirin-induced bronchospasm. Ann Allergy Asthma Immunol. 2005 Oct;95(4):307-8. Review.

13684.     Mandell D, Curtis R, Gold M, Hardie S.  Anaphylaxis: how do you live with it? Health Soc Work. 2005 Nov;30(4):325-35.

13685.     McClelland VM, Brookfield DS.  Palpation reveals the diagnosis. Arch Dis Child. 2005 Dec;90(12):1278.

13686.     McIntyre CL, Sheetz AH, Carroll CR, Young MC. Administration of epinephrine for life-threatening allergic reactions in school settings. Pediatrics. 2005 Nov;116(5):1134-40.

13687.     Moss JR, Zanation AM, Shores CG. ACE inhibitor associated recurrent intermittent parotid gland swelling. Otolaryngol Head Neck Surg. 2005 Dec;133(6):992-4.

13688.     Nadarajah K, Green GR, Naglak M.   Clinical outcomes of penicillin skin testing.Ann Allergy Asthma Immunol. 2005 Dec;95(6):541-5. 

13689.     Neri I, Savoia F, Guareschi E, Medri M, Patrizi A.  Purpura after application of EMLA cream in two children. Pediatr Dermatol. 2005 Nov-Dec;22(6):566-8. 

13690.     Newcomb AE, Clarke CP. Spontaneous pneumomediastinum: a benign curiosity or a significant problem? Chest. 2005 Nov;128(5):3298-302.

13691.     Nicol AA. Understanding peanut allergy: an overview of medical and lifestyle concerns. Adv Nurse Pract. 2005 Oct;13(10):63-8. Review.

13692.     Opstelten W, van Essen GA, Moons KG, van Wijck AJ, Schellevis FG, Kalkman CJ, Verheij TJ.   Do herpes zoster patients receive antivirals? A Dutch National Survey in General Practice. Fam Pract. 2005 Oct;22(5):523-8. 

13693.     Paajanen L, Korpela R, Tuure T, Honkanen J, Jarvela I, Ilonen J, Knip M,Vaarala O, Kokkonen J.   Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study. Am J Clin Nutr. 2005 Dec;82(6):1327-35.

13694.     Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. J Allergy Clin Immunol. 2005 Oct;116(4):869-75. 

13695.     Schreck DM, Babin S.  Comparison of racemic albuterol and levalbuterol in the treatment of acute asthma in the ED. Am J Emerg Med. 2005 Nov;23(7):842-7.

13696.     Sevar R. Audit of outcome in 455 consecutive patients treated with homeopathic medicines. Homeopathy. 2005 Oct;94(4):215-21. 

13697.     Soylu A, Kavukcu S, Erdur B, Demir K, Turkmen MA. Multisystemic leukocytoclastic vasculitis affecting the central nervous system. Pediatr Neurol. 2005 Oct;33(4):289-91.

13698.     Stover DE, Mangino D. Macrolides: a treatment alternative for bronchiolitis obliterans organizing pneumonia? Chest. 2005 Nov;128(5):3611-7.

13699.     Wickens K, Barry D, Friezema A, Rhodius R, Bone N, Purdie G, Crane J.  Fast foods - are they a risk factor for asthma? Allergy. 2005 Dec;60(12):1537-41.

13700.     Zacharisen M, Schoenwetter W. Fatal hypersensitivity pneumonitis. Ann Allergy Asthma Immunol. 2005 Nov;95(5):484-7.

13701.     Zanconato S, Meneghelli G, Braga R, Zacchello F, Baraldi E. Office spirometry in primary care pediatrics: a pilot study. Pediatrics. 2005 Dec;116(6):e792-7.


13702.     Allmers H. Frequent acetaminophen use and allergic diseases: is the association clear? J Allergy Clin Immunol. 2005 Oct;116(4):859-62. Review. 

13703.     Bjorksten B. Evidence of probiotics in prevention of allergy and asthma. Curr Drug Targets Inflamm Allergy. 2005 Oct;4(5):599-604. Review.

13704.     Britton J. Passive smoking and asthma exacerbation. Thorax. 2005 Oct;60(10):794-5. 

13705.     Corkins MR. Are diet and constipation related in children? Nutr Clin Pract. 2005 Oct;20(5):536-9. Review.

13706.     Davoren M, Peake J. Cashew nut allergy is associated with a high risk of anaphylaxis.Arch Dis Child. 2005 Oct;90(10):1084-5.

13707.     Demiraran Y, Kocaman B, Akman RY. A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children. Br J Anaesth. 2005 Oct;95(4):510-3. 

13708.     Eskinazi D.  Vaccinations: for or against. Homeopathy. 2005 Oct;94(4):252-3. 

13709.     Haroon M. Should children with Henoch-Schonlein purpura and abdominal pain be treated with steroids? Arch Dis Child. 2005 Nov;90(11):1196-8. Review. 

13710.     Holgate ST. Exacerbations: the asthma paradox. Am J Respir Crit Care Med. 2005 Oct 15;172(8):941-3. Review. 

13711.     Jolles S, Sewell WA, Misbah SA.  Clinical uses of intravenous immunoglobulin. Clin Exp Immunol. 2005 Oct;142(1):1-11. Review. Jun ZJ, Lei Y, Shimizu Y, Dobashi K, Mori M. Helicobacter pylori seroprevalence in patients with mild asthma. Tohoku J Exp Med. 2005 Dec;207(4):287-91.

13712.     King N, Helm R, Stanley JS, Vieths S, Luttkopf D, Hatahet L, Sampson H, Pons L, Burks W, Bannon GA. Allergenic characteristics of a modified peanut allergen. Mol Nutr Food Res. 2005 Oct;49(10):963-71.

13713.     Latha GS, Lakshmi VV, Rani HS, Anuradha B, Murthy KJR. Specific IgG and its subclass antibodies after immunotherapy with gynandropsis gynandra . Lung India. 2005 Jul-Sept; 22(3): 77-80

13714.     Miller MM, Miller MM.  Beta-blockers and anaphylaxis: are the risks overstated? J Allergy Clin Immunol. 2005 Oct;116(4):931-3; author reply 933-6.

13715.     Richardson L. Re: "please read the following paper and write this way!". Am J Epidemiol. 2005 Oct 1;162(7):706-7. 

13716.     Romero-Frais E, Vazquez MI, Sandez E, Blanco-Aparicio M, Otero I, Verea H.  Prescription of oral corticosteroids in near-fatal asthma patients: relationship with panic-fear, anxiety and depression. Scand J Psychol. 2005 Oct;46(5):459-65.

13717.     Su SS, Yu KH, Woung PS. Comment: esomeprazole-induced central fever with severe myalgia. Ann Pharmacother. 2005 Oct;39(10):1764; author reply 1765. 

13718.     van Rijt LS, van Kessel CH, Boogaard I, Lambrecht BN. Respiratory viral infections and asthma pathogenesis: a critical role for dendritic cells? J Clin Virol. 2005 Nov;34(3):161-9.  Review.

13719.     Ward MD, Selgrade MK. Benefits and risks in malaria control. Science. 2005 Oct 7;310(5745):49-51; author reply 49-51. 

13720.     Zanoni LZ, Palhares DB, Consolo LC. Myocardial ischemia induced by nebulized fenoterol for severe childhood asthma. Indian Pediatr. 2005 Oct;42(10):1013-8.

13721.     Zinderman CE, Wise R, Landow L. Fluid solutions in dengue shock syndrome. N Engl J Med. 2005 Dec 8;353(23):2510-1; author reply 2510-1.



13722.      Ahrens RC. The role of the MDI and DPI in pediatric patients: "Children are not just miniature adults". Respir Care. 2005 Oct;50(10):1323-8; discussion 1328-30. Review.

13622.    Ali R, Ali S, Saeed SA, Khan A, Mustafa M, Aleem S. Latest approaches to the diagnosis and management of food allergies in children. J Pak Med Assoc. 2005 Oct;55(10):458-62. Review.

13624.    Arroliga A, Griswold S. "Frequent fliers" do not receive a free trip in the emergency department. Chest. 2005 Dec;128(6):4051-2. 

13625.    Boogaard R, Huijsmans SH, Pijnenburg MW, Tiddens HA, de Jongste JC, Merkus PJ. Tracheomalacia and bronchomalacia in children: incidence and patient characteristics. Chest. 2005 Nov;128(5):3391-7.

13626.    Choo-Kang LR. Becoming a complete "asthmologist". Chest. 2005 Nov;128(5):3093-6. 

13627.   Currie GP, Lee DK, Srivastava P. Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma? Chest. 2005 Oct;128(4):2954-62. Review.

13628.    Field T. Massage therapy for skin conditions in young children. Dermatol Clin. 2005 Oct;23(4):717-21. Review.

13629.    Flores G, Abreu M, Tomany-Korman S, Meurer J. Keeping children with asthma out of hospitals: parents' and physicians'perspectives on how pediatric asthma hospitalizations can be prevented. Pediatrics. 2005 Oct;116(4):957-65.

13630.    Hanania NA, Belfort MA.  Acute asthma in pregnancy.Crit Care Med. 2005 Oct;33(10 Suppl):S319-24. Review.

13631.    Martinez FD. Safety of long-acting beta-agonists--an urgent need to clear the air. N Engl J Med. 2005 Dec 22;353(25):2637-9. 

13632.    Nardi AE. Where are the guidelines for the treatment of asthma with panic spectrum symptoms? Am J Respir Crit Care Med. 2005 Oct 15;172(8):1055-6; author reply 1056.

13633.    Nott MR. Helium-oxygen for asthma. Anaesthesia. 2005 Oct;60(10):1044-5. 

13634.    Trumpelmann P, Jordan G, Townsend M. Hydrocortisone preparations and latex. Anaesthesia. 2005 Dec;60(12):1246; discussion 1246-7. 

13635.    Yeh SH, Chang FR, Wu YC, Yang YL, Zhuo SK, Hwang TL. An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions. Planta Med. 2005 Oct;71(10):904-9.  





July 2006

Some selected abstracts:


Braganza SC, Acworth JP, Mckinnon DR. Peake JE, Brown AF, Paediatric emergency department anaphylaxis : different patterns from adults. Arch Dis. Child. 2006Feb; 91(2):159-63

Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia.

BACKGROUND AND AIMS: Data on acute paediatric anaphylaxis presentations to the emergency department (ED) are limited. All allergic presentations to one Australian paediatric ED were studied to determine epidemiological, clinical, and outcome data. METHODS: Retrospective, case based study of patients under 16 years attending one metropolitan, paediatric teaching hospital ED in Australia over three years. The medical records of patients presenting with generalised allergic reactions and anaphylaxis satisfying relevant ICD-9-CM diagnostic codes were studied. The incidence, age, sex ratio, co-morbidities, likely aetiology, clinical features, management, and disposal were determined. RESULTS: A total of 526 children with generalised allergic reactions, and 57 with anaphylaxis were included in the study. This represented incidences of 9.3:1000 ED presentations for generalised allergic reactions and 1:1000 for anaphylaxis. There were no fatalities. In anaphylaxis cases, a cause was recognised in 68.4%. Cutaneous features were present in 82.5%. A past history of asthma was reported in 36.8%. Adrenaline was used in 39.3% of severe anaphylaxis cases. The ED alone definitively cared for 97.8% of all patients. Follow up was inadequate in cases of anaphylaxis. CONCLUSIONS: This is the first reported incidence figure for paediatric anaphylaxis ED presentations in Australia, and is less than that reported in adults in the same local population. However, the incidence of generalised allergic reactions of 9.3:1000 was greater than in the adults. Virtually all paediatric allergic cases may be managed in the ED alone, provided that the importance of specialist follow up, particularly for severe anaphylaxis, is recognised.



Carroll CL, Schramm CM. Noninvasive positive pressure ventilation for the treatment of status asthmaticus in children. Ann Allergy Asthma Immunol. 2006 Mar;96(3):454-9.

Department of Pediatrics, Connecticut Children´┐Żs Medical Center, Hartford, Connecticut 06106, USA.

BACKGROUND: Noninvasive positive pressure ventilation (NPPV) has been used safely and effectively to improve gas exchange and to treat respiratory failure in a variety of disease states. Although this technique has some benefits in the treatment of status asthmaticus in adults, the use of NPPV in pediatric patients with asthma has not been described. OBJECTIVE: To describe the use of NPPV in the treatment of pediatric status asthmaticus. METHODS: Retrospective review of children admitted to the inten sive care unit with asthma who received NPPV as part of their treatment between Octo ber 2002 and April 2004. Before and after initiation of NPPV, data were collected regarding degree of respiratory dysfunction. RESULTS: Of seventy-nine children admitted to the intensive care unit during the study period for treatment of status asthmaticus, 5 children (mean +/- SD age, 9.6 +/- 4.2 years) were treated with NPPV. Four of the 5 children were morbidly obese, with a mean +/- SD body mass index of 32 +/- 5. There was a statistically significant improvement in respiratory rate (43 +/- 20 vs 31 +/- 12/min, P = 03) and Modified Pulmonary Index Score (13.4 +/- 1.8 vs 11.4 +/- 1.5, P = .03) after initiation of NPPV. The mean +/- SD duration of therapy was 33.2 +/- 23.9 hours, and children tolerated this therapy well, requiring little or no anxiolytics. CONCLUSIONS: NPPV was well tolerated in this series of children with status asthmaticus and can improve subjective and objective measures of respiratory dysfunction. NPPV may be a useful adjunct in the treatment of status asthmaticus in children.


Rowe BH, Camargo CA Jr; Multicenter Airway Research Collaboration (MARC) Inves tigators. The use of magnesium sulfate in acute asthma: rapid uptake of evidence in North American emergency departments. J Allergy Clin Immunol. 2006 Jan;117(1):53-8.

Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

BACKGROUND: Systematic reviews of approximately 13 randomized trials support treatment with intravenous magnesium sulfate (MgSO(4)) in patients with severe acute asthma; however, little is known about its actual clinical use. OBJECTIVE: We sought to examine the use of intravenous MgSO(4) in the emergency department (ED) and physician attitudes toward its use. METHODS: Data for MgSO(4) use were obtained from observational cohort studies of ED patients with acute asthma. Investigators were asked about MgSO(4) through a brief Internet-based survey. The main outcomes were the percentage of sites reporting MgSO(4) use and patient factors that potentially modified the use of this agent. RESULTS: Among 9745 ED patients with acute asthma, 240 (2.5%) received MgSO(4). Increasing age, previous intubation, higher initial respiratory rate, lower initial PEF, higher number of beta-agonists in the ED, and use of systemic corticosteroids were associated with MgSO(4) use (P < .01). Overall, 103 (87%) of 119 potential sites completed the survey. Most (92%) respondents stated their EDs had MgSO(4) available, and 64% had recently used it. More respondents listed severity (96%) and failure to respond to initial beta-agonists (87%) as factors prompting their use of MgSO(4). Other factors, such as age, sex, and duration of exacerbation, less commonly influenced MgSO(4) use. CONCLUSION: Most ED physicians accept the efficacy of MgSO(4) in acute asthma. Despite this belief and the ready availability of MgSO(4), its ED use remains uncommon (2.5% of cases). In both practice and theory, emergency physicians appear to appropriately restrict its use to patients with severe acute asthma.


Seddon P, Bara A, Ducharme FM, Lasserson TJ. Oral xanthines as maintenance treatment for asthma in children. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD00288

Royal Alexandra Hospital for Sick Children, Dyke Road, Brighton, Sussex, UK, BN1

BACKGROUND : Xanthines have been used in the treatment of asthma as a bronchodilator, though they may also have anti-inflammatory effects. The current role of xanthines in the long-term treatment of childhood asthma needs to be reassessed.

OBJECTIVES : To determine the efficacy of xanthines (e.g. theophylline) in the maintenance treatment of paediatric asthma. SEARCH STRATEGY: A search of the Cochrane Airways Group Specialised Register was undertaken with predefined search terms. Searches are current to May 2005. SELECTION CRITERIA : Randomised controlled trials,lasting at least four weeks comparing a xanthine with placebo, regular short-acting beta-agonist (SABA), inhaled corticosteroids (ICS), cromoglycate (SCG), ketotifen (KET) or leukotriene antagonist, in children with diagnosed with chronic asthma between 18 months and 18 years old. DATA COLLECTION AND ANALYSIS : Two reviewerd independently selected each study for inclusion in the review and extracted data. Primary outcome was percentage of symptom-free days. MAIN RESULTS: Thirty- four studies (2734 participants) of adequate quality were included. Xanthine versus placebo (17 studies): The proportion of symptom free days was larger with xanthine compared with placebo (7.97% [95% CI 3.41, 12.53]). Rescue medication usage was lower with xanthine, with no significant difference in symptom scores or hospitalisations. FEV1 , and PEF were better with xanthine. Xanthine was associated with non - specific side-effects.Data from behavioural scores were inconclusive. Xanthine versus ICS (four studies) :Exacerbations were less frequent with ICS, but no significant difference on lung function was observed. Individual studies reported significant improvements in symptom measures in favour of steroids, and one study reported a difference in growth rate in favour of xanthine. No difference was observed for study withdrawal or tremor. Xanthine was associated with more frequent headache and nausea. Xanthine versus regular SABA (10 studies):  No significant difference in symptoms, rescue medication usage and spirometry. Individual studies reported improvement in PEF with beta-agonist. Beta-agonist treatment led to fewer hospitalisations and headaches. Xanthine was associated with less tremor. Xanthine versus SCG (six studies ): No significant difference in symptoms, exacerbations and rescue medication. Sodium cromoglycate was associated with fewer gastro-intestinal side-effected than xanthine. Xanthine versus KET (one study): No statistical tests of significance between xanthine and ketotifen were reported. Xanthine + ICS versus placebo + same dose ICS} (three studies) : Results were conflicting due to clinical/methodological differences, and could not be aggregated. AUTHORS' CONCLUSIONS : Xanthines as first-line preventer alleviate symptoms and reduce requirement for rescue medication in children with mild to moderate asthma. When compared with ICS they were less effective in preventing exacerbations.Xanthines had similar efficacy as single preventative agent compared with regular SABA and SCG. Evidence on AEs (adverse effects) was equivocal: there was evidence for increased AEs overall, but no evidence that any specific AE (including effects on behaviour and attention) occurred more frequently than with placebo. There is insufficient evidence from available studies to make firm conclusions about the effectiveness of xanthines as add-on preventative treatment to ICS, and there are no published paediatric studies comparing xanthines with alternatives in this role. Our data suggest that xanthines are only suitable as first-line preventative asthma therapy in children when ICS are not available. They may have a role as add-on therapy in more severe asthma not controlled by ICS, but further studies are needed to examine this, and to define the risk-benefit ratio compared with other agents.


Wigmore T, Stachowski E. A review of the use of heliox in the critically ill. Crit Care Resusc.2006 Mar;8(1):64-72.

Intensive Care Unit, Westmead Hospital, Westmead, New South Wales.

Heliox, a mix of oxygen and helium, has a number of potential medical applications resulting from its relatively lower density. This paper reviews the physics underlying its utility and considers the evidence for its use. While there are studies that support its role, particularly in patients with exacerbations of asthma and chronic obstructive pulmonary disease (COPD), the data are inconclusive.

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:

14246.  Al-Trabolsi HA, Alshehri M, Al-Shomrani A, Shabanah M, Al-Barki AA."Primary" pulmonary Langerhans cell histiocytosis in a two-year-old child: case report and literature review. J Pediatr Hematol Oncol. 2006 Feb;28(2):79-81. Review.

14247.  Amado MC, Portnoy JM. Recent advances in asthma management. Mo Med. 2006 Jan-Feb;103(1):60-4. Review.

14248.  Brightling CE. Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence- based clinical practice guidelines.Chest. 2006 Jan;129(1 Suppl):116S-121S. Review.

14249. Brightling CE. Sputum induction in asthma: a research technique or a clinical tool? Chest.2006 Mar;129(3):503-4.

14250.  Chhabra SK. Premenstrual asthma. Indian J Chest Disall Sci. 2005; 47(2):109-16.

14251.  Dinakar C, Craff M, Laskowski D.Infants and toddlers without asthma with eczema have elevated exhaled nitric oxide levels.J Allergy Clin Immunol. 2006 Jan;117(1):212-3.

14252. Doherty S.Evidence-based implementation of evidence-based guidelines.Int J Health Care Qual Assur Inc Leadersh Health Serv. 2006;19(1):32-41.

14253. Fitzgerald DA, Kozlowska K.Habit cough: assessment and management.Paediatr Respir Rev. 2006 Mar;7(1):21-5. Review.

14254. Flaherman V, Rutherford GW.A meta-analysis of the effect of high weight on asthma.Arch Dis Child. 2006 Apr;91(4):334-9. Review.

14255. Fuhlbrigge AL, Bae SJ, Weiss ST, Kuntz KM, Paltiel AD. Cost-effectiveness of inhaled steroids in asthma: impact of effect on bone mineral density.J Allergy Clin Immunol. 2006 Feb;117(2):359-66.

14256. Gau JT, Carlsen W, Tomc M, Jenkinson S, Shen R, Clay S. An elderly woman with
asthma and eosinophilia presenting with fluctuating hoarseness and laryngopyocele.J Am Geriatr Soc. 2006 Feb;54(2):367-8. .

14257. Gruchalla RS, Pirmohamed M.Clinical practice. Antibiotic allergy.N Engl J Med. 2006
Feb 9;354(6):601-9. Review. .

14258. Hahn DL. Does most asthma really begin during the preschool years? Am J Respir Crit Care Med. 2006 Mar 1;173(5):575-6; Halterman JS, Fagnano M, Conn KM, Szilagyi PG. Do parents of urban children with persistent asthma ban smoking in their homes and cars? Ambul Pediatr. 2006 Mar-Apr;6(2):115-9.

14259. Hambrook DW, Fink JN. Airbag asthma: a case report and review of the literature. Ann Allergy Asthma Immunol. 2006 Feb;96(2):369-72. Review.

14260. Hong SH, Sanders BH, West D. Inappropriate use of inhaled short acting beta-agonists
and its association with patient health status. Curr Med Res Opin. 2006 Jan;22(1):33-40.

14261. Kaur C, Bansal SK, Chhabra SK. Study on serum and urinary cortisollevels of asthmatic patients after treatment with high dose inhaledbeclomethasone dipropionate or budesonide. Indian J Chest Dis all Sci. 2005; 47(2):89-95.

14262. Kwon HL, Belanger K, Holford TR, Bracken MB.Effect of fetal sex on airway lability in pregnant women with asthma. Am J Epidemiol. 2006 Feb 1;163(3):217-21.

14263. Nitta A, Suzumura H, Tsuboi Y, Yoshihara S, Arisaka O. Cow's milk allergy with severe atopic dermatitis in a 605-g extremely low birth weight infant. J Pediatr. 2006 Feb;148(2):282.

14264. Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, Brown SG, Camargo CA Jr, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor D Jr, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW. Second sympo sium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.J Allergy Clin Immunol. 2006 Feb;117(2):391-7.

14265. Schatz M, Dombrowski MP, Wise R, Momirova V, Landon M, Mabie W, Newman RB, Rouse DJ, Lindheimer M, Miodovnik M, Caritis SN, Leveno KJ, Meis P, Wapner RJ, Paul RH, O'Sullivan MJ, Varner MW, Thurnau GR, Conway DL; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network; National Heart, Lung, and Blood Institute. Spirometry is related to perinatal outcomes in pregnant women with asthma. Am J Obstet Gynecol. 2006 Jan;194(1):120-6.

14266. Simons FE. Anaphylaxis, killer allergy: long-term management in the community.J Allergy Clin Immunol. 2006 Feb;117(2):367-77. Review.

14267. Svedman C, Tillman C, Gustavsson CG, Moller H, Frennby B, Bruze M. Contact allergy to gold in patients with gold-plated intracoronary stents. Contact Dermatitis. 2006

14268. Ulger Z, Demir E, Tanac R, Goksen D, Gulen F, Darcan S, Can D, Coker M. The effect of childhood obesity on respiratory function tests and airway hyperresponsiveness. Turk J Pediatr. 2006 Jan-Mar;48(1):43-50.


14269. Aaronson DW. The "black box" warning and allergy drugs. J Allergy Clin Immunol. 2006 Jan;117(1):40-4.

14270. Ait-Khaled N, Enarson DA. Management of asthma: the essentials of good clinical prac tice. Int J Tuberc Lung Dis. 2006 Feb;10(2):133-7. Review.

14271. Alonso A, Jick SS, Hernan MA. Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis. Neurology. 2006 Feb 28;66(4):572-5.

14272. Amon A, Pahl A, Szelenyi I. Can corticosteroids be beaten in future asthma therapy? Pharmazie. 2006 Feb;61(2):122-4. Review.

14273.  Barnes PJ. Corticosteroids: the drugs to beat. Eur J Pharmacol. 2006 Mar 8;533(1-3):2- 14. Review.

14274.  Basaran S, Guler-Uysal F, Ergen N, Seydaoglu G, Bingol-Karakoc G, Ufuk Altintas D. Effects of physical exercise on quality of life, exercise capacity and pulmonary function in children with asthma. J Rehabil Med. 2006 Mar;38(2):130-5.

14275. Broadley KJ. Beta-adrenoceptor responses of the airways: for better or worse? Eur J Pharmacol. 2006 Mar 8;533(1-3):15-27. Review.

14276.  Camargo CA Jr. Prevention of emergency department visits for acute asthma. Ann  Allergy Asthma Immunol. 2006 Feb;96(2):258-9.

14277. Cates C. Is a leukotriene receptor antagonist as effective as a long-acting beta2-agonist at reducing asthma exacerbations? Chest. 2006 Mar;129(3):826; author reply 826-7.

14278. Cates CJ, Bestall J, Adams N. Holding chambers versus nebulisers for inhaled steroids in chronic asthma. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD001491. Review.

14279. Coffey MJ, Ross LF. Ethics of placebos in clinical asthma trials. J Allergy Clin Immunol. 2006 Feb;117(2):470; author reply 470-1.

14280. Curtiss FR. Asthma disease management--evidence-based medicine must be dynamic. J Manag Care Pharm. 2006 Jan-Feb;12(1):80-2.

14281. Cydulka RK. Acute asthma during pregnancy. Immunol Allergy Clin North Am. 2006 Feb;26(1):103-17. Review.

14282. Davis JJ, Bailey WC. Teach a man to fish and you have fed him for a lifetime. Chest. 2006 Feb;129(2):220-1.

14283. Ekici A, Ekici M, Kara T, Keles H, Kocyigit P. Negative mood and quality of life in patients with asthma. Qual Life Res. 2006 Feb;15(1):49-56.

14284. Fan Chung K. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol. 2006  Mar 8;533(1-3):110-7. Review.

14285. Fell DB, Dodds L, Joseph KS, Allen VM, Butler B. Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy. Obstet Gynecol. 2006 Feb;107 (2 Pt 1) : 277 - 84.

14286. Gelfand EW, Georgitis JW, Noonan M, Ruff ME. Once-daily ciclesonide in children: efficacy and safety in asthma. J Pediatr. 2006 Mar;148(3):377-83.

14287. Gupta RS, Bewtra M, Prosser LA, Finkelstein JA. Predictors of hospital charges for children admitted with asthma. Ambul Pediatr. 2006 Jan-Feb;6(1):15-20.

14288. Hambrook DW, Fink JN. Airbag asthma: a case report and review of the literature. Ann Allergy Asthma Immunol. 2006 Feb;96(2):369-72. Review.

14289. Jenkins A. Take a deep breath. Nurs Stand. 2006 Mar 1-7;20(25):32.

14290. Marr L. Revealing images. J Palliat Med. 2006 Feb;9(1):211-2.

14291. Mathur SK, Busse WW. Asthma: diagnosis and management. Med Clin North Am. 2006 Jan;90(1):39-60. Review.

14292. Mintz ML. Safety of long-acting beta-agonists. N Engl J Med. 2006 Mar 16;354(11):1206- 8; author reply 1206-8.

14293. Moore PA, Hersh EV. Common medications prescribed for adolescent dental patients. Dent Clin North Am. 2006 Jan;50(1):139-49, vii.

14294. Potter PC. Update on sublingual immunotherapy. Ann Allergy Asthma Immunol. 2006 Feb;96(2 Suppl 1):S22-5. Review.

14295. Prakash UB. Uncommon causes of cough: ACCP evidence-based clinical practice guide lines. Chest. 2006 Jan;129(1 Suppl):206S-219S. Review.

14296. Rodrigo GJ, Nannini LJ. Comparison between nebulized adrenaline and beta2 agonists for the treatment of acute asthma. A meta-analysis of randomized trials. Am J Emerg Med. 2006 Mar;24(2):217-22.

14297. Sin DD, Man SF. Corticosteroids and adrenoceptor agonists: the compliments for combi nation therapy in chronic airways diseases. Eur J Pharmacol. 2006 Mar 8;533(1-3):28-35.



October 2006


Some selected abstracts:


Arcola T, Ruuska T, Keranen J, Hyoty H, Salminen S, Isolauri E.  Rectal bleeding in infancy: clinical,     allergological, and microbiological examination.Pediatrics. 2006 Apr;117(4):e760-8.
Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
OBJECTIVE: Rectal bleeding is an alarming symptom and requires additional investigation. In infants it has been explained mainly by hypersensitivity. In addition to dietary antigens, intraluminal microbial agents challenge the immature gut mucosa. Although controlled in the mature gut, these antigens may induce inflammation in the developing gastrointestinal tract. The objectives of this study were to evaluate prospectively the clinical course of rectal bleeding and evaluate the impact of cow's milk allergy and aberrant gut microbiota on the condition. Because withdrawal of cow's milk antigens from the infants' diet is used as a first treatment without evidence of its efficacy, we also aimed to asses the effect of a cow's milk-elimination diet on the duration of rectal bleeding. METHODS: The study involved 40 consecutive infants (mean age: 2.7 months) with visible rectal bleeding during a 2-year period at the Tampere University Hospital Department of Pediatrics. Most of the infants (68%) were fully breastfed. At enrollment the infants were randomly allocated to receive a cow's milk-elimination diet (n = 19) or continue their previous diet (n = 21) for 1 month. Findings of colonoscopy, fecal bacterial culture, fluorescence in situ hybridization of selected gut genera, specific detection of fecal enteroviruses, rotaviruses, and adenoviruses, fecal electron microscopy for viruses, and mucosal electron microscopy for viruses were assessed. During each visit the severity of atopic eczema, if any, was assessed according to the SCORAD method. In evaluating the extent of sensitization, serum total immunoglobulin E (IgE) and specific IgE and skin-prick tests for cow's milk, egg, and wheat were studied. Cow's milk allergy was diagnosed by elimination and provocation testing. Five patients were hospitalized; all others were treated on an outpatient basis. The follow-up visits were scheduled 1 month later and at the age of 1 year. Sixty-four healthy reference infants were selected as controls according to the following criteria: age and timing of fecal sampling being identical to within 1 month. RESULTS: Altogether, 32 (80%) infants manifested bloody stools during follow-up (mean [range]: 2.1 [1-15] per day). The mean number of days with rectal bleeding on follow-up was 6. Typically, bloody stools occurred irregularly, for which reason the mean time to the last occurrence of rectal bleeding was 24 (range: 1-85) days from admission. Atopic eczema at presentation or during follow-up was diagnosed in 38% of the infants. Increased specific IgE concentrations or a positive skin-prick test were uncommon. The growth of the infants was normal on admission and during follow-up. Colonoscopy revealed typically focal mucosal erythema and aphthous ulcerations. The mucosa appeared normal in less than half of the patients. No anorectal fissures or colonic polyps were found. Light microscopy revealed that the overall architecture of the mucosa was well maintained. Acute inflammation or postinflammatory state and focal infiltration of eosinophils in the lamina propria were the most common abnormalities. A cow's milk-elimination diet did not affect the duration of rectal bleeding. Cow's milk allergy was diagnosed in 7 (18%) patients. Virus-particle aggregates were found in the microvillus layer of the colon epithelium in 8 cases. The surface epithelium of the virus-positive colon biopsy specimens regularly showed degenerative changes in the microvillus layer and epithelial cells. Electron microscopy study of the colon biopsies disclosed virus particles (30 nm in diameter) on the surface of epithelial cells. Virus particles or RNA were present in feces in only a minority of the patients. All fecal cultures were negative for Salmonella, Shigella, and Yersinia. Campylobacter jejuni was found in the feces of 1 patient, and fecal cultures were positive for Clostridium difficile in 4 patients, Staphylococcus aureus in 8 patients, and yeast in 2 patients. Fluorescence in situ hybridization revealed that at the time of admission the total numbers of bacteria and the numbers of bifidobacteria and lactobacilli in feces were lower in the patients compared with controls. The fecal concentrations of microbes characterized in this study (Bacteroides, bifidobacteria, Clostridium, lactobacilli, and enterococci) did not differ significantly between the time of admission and the second visit in the patients or controls. At the age of 1 year, 7 patients still suffered from cow's milk allergy, 5 of whom also suffered from multiple food allergies. Atopic eczema and histopathologically confirmed inflammation of the colonic mucosa at presentation were associated with persistence of cow's milk allergy at the age of 1 year. No patients exhibited gastrointestinal complaints or visible blood in stools. CONCLUSIONS: Rectal bleeding in infants is generally a benign and self-limiting disorder. Bloody stools occurred irregularly for only a few days during the following months. As in a previous report, most infants were exclusively breastfed. In the majority of the patients the cause of the condition remains unknown. An association with viruses can be seen in some patients. The microbes that commonly lead to bloody diarrhea in older children and adults, Salmonella, Shigella, and Yersinia, were absent in the present material. The low bifidobacterial numbers in fecal samples may indicate a significant aberrance that may provide a target for probiotic intervention to normalize gut microbiota. The gut microbiota overall seemed stable, because the numbers of major groups of microbiota tested did not change significantly between the time of admission and after 1 month. Cow's milk allergy among these patients is more uncommon than previously believed. Cow's milk challenge is thus essential in infants who become symptom-free during a cow's milk-free diet to reduce the number of false-positive cow's milk-allergy diagnoses.


Devadason SG.  Recent advances in aerosol therapy for children with asthma. J Aerosol Med. 2006 Spring;19(1):61-6. Review.

School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, Australia.

Inhalational drug delivery is the primary mode of asthma therapy in children and is the main focus of this article. Pressurized metered dose inhalers (pMDIs) are now the method of choice in infants and children under 5 years old, when used in combination with an appropriate valved holding chamber or spacer. Spacers are particularly important for steroid inhalation to maximize lung deposition and minimize unwanted oropharyngeal deposition. Optimal inhalation technique with a pMDI-spacer in infants is to inhale the drug by breathing tidally through the spacer. Drug delivery to the lungs using pMDIs can vary greatly, depending on the formulation used and the age of the child. Dry powder inhalers (DPIs) are driven by the peak inspiratory flow of the patient and are usually not appropriate for children under 5 or 6 years of age. Nebulizers continue to play a role in the treatment of acute asthma where high doses of bronchodilator are required, though multiple doses via pMDI spacer may suffice. Important drug delivery issues specific to children include compliance, use of mask versus mouthpiece, lower tidal volumes and inspiratory flows, determination of appropriate dosages, and minimization of adverse local and systemic effects.


Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):220-5. Review.
Department of Allergy, Royal Children's Hospital, Parkville, Victoria, Australia.

PURPOSE OF REVIEW: This review assesses the role of food allergy in the pathophysiology of gastroesophageal reflux disease, colic and constipation in infancy. RECENT FINDINGS: Frequent regurgitation, persistent crying and constipation are common clinical problems in infancy. A subgroup of infants with these conditions may respond to hypoallergenic diets, but only few randomized clinical trials have been conducted. Skin prick testing and food-specific antibody levels are usually not elevated in these infants, whereas atopy patch testing may diagnostic. The mechanisms by which cow's milk and other food allergens induce gastrointestinal motility disorders are not understood. Apart from cell-mediated reactions, non-immunological effects of food constituents on gastrointestinal motility and gut microbiota may be involved in the pathogenesis. In the absence of reliable diagnostic tests, dietary elimination and re-challenge are usually required to confirm food allergy. A trial of amino acid-based formula or an oligoantigenic maternal elimination diet may be indicated in infants who have failed conventional medical treatment. SUMMARY: Food allergy may contribute to gastroesophageal reflux disease, colic or constipation in infancy. Infants with these conditions often respond to hypoallergenic formula or a maternal elimination diet. Further research is needed to define the mechanisms and clinical markers of gastrointestinal food allergy in infancy.


Hickey AJ, Lu D, Ashley ED, Stout J.  Inhaled azithromycin therapy. J Aerosol Med. 2006 Spring;19(1):54-60.

Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA. 

The treatment of pulmonary infectious diseases with pharmaceutical aerosols is an attractive option considering the accessibility of the lungs for topical drug delivery. Aerosols have been targeted to the lungs for the treatment of asthma with great success. Current therapies for other diseases, including Pseudomonas aeruginosa, Pneumocystis jirovecii (formerly Pneumocystis carinii), and mycobacterial infections, remain suboptimal due to the efficacy/safety profile. This may be improved by aerosol targeted pulmonary drug delivery. Azithromycin is a broad spectrum antibiotic that acts by inhibiting protein synthesis. It is associated with side effects that might be avoided by aerosol delivery to the lungs. In the present study three concentrations of azithromycin (10, 50, and 100 mg/mL) were delivered from three nebulizers (Acorn II, Updraft, and LC Plus) operated at 8 L/min. Particles size analyses were conducted by inertial impaction and laser diffraction. In addition, emitted doses were determined. A linear proportionality existed across the concentration range between nominal dose and both fine particle dose/fraction and emitted dose, with R2 > 0.999 in all cases. The mass median aerodynamic diameter increased from 1.4 to 1.9 microm between 10 and 100 mg/mL of azithromycin solution concentration for the Acorn II. The particle size distributions were not all log-normally distributed. The median particle size delivered from the devices was largest for the Updraft (2.8 microm) and smallest for the Acorn II (1.9 microm) for 100 mg/mL azithromycin solution concentrations. The efficiencies of small particle delivery (%<4.7 microm) were as follows, LC Plus = Acorn II (85%) > UpDraft (75%). However, the emitted dose from the LC Plus (55 mg/min) was higher than the Acorn II (31 mg/min) to maximize lung exposure to the aerosol, small median diameters and broad particle size distributions would be most effective. This study demonstrates that the dose delivered to the lungs will be maximized, under the current operating conditions by adopting the LC Plus, and high (100 mg/mL) azithromycin concentrations.


Shiber JR, Santana J. Dyspnea. Med Clin North Am. 2006 May;90(3):453-79. Review.
Department of Medicine,
East Carolina University, Greenville, NC 27834, USA.

When evaluating a dyspneic patient in the office, a quick initial assessment of the airway, breathing, and circulation, while gathering a brief history and focused physical examination are necessary. Most often, an acute cardiopulmonary disorder, such as CHF, cardiac ischemia, pneumonia, asthma, or COPD exacerbation, can be identified and treated. Stable patients who improve can be sent home, but those in acute distress with unstable or impending unstable conditions need to be transferred emergently to definitive care. Because of the difficult logistics involved in attempting to work up an outpatient for new onset of SOB, some patients will need to be transferred to the nearest ED for a definitive diagnosis.


Sun HL, Kao YH, Chou MC, Lu TH, Lue KH. Differences in the prescription patterns of anti-asthmatic medications for children by pediatricians, family physicians and physicians of other specialties. J Formos Med Assoc. 2006 Apr;105(4):277-83.
Department of Pediatrics,
Chung Shan Medical University Hospital, and Institute of Medicine, Taichung, Taiwan.

BACKGROUND: Prescription patterns of anti-asthma medications in children vary among doctors in different disciplines and settings, and may reflect differences in treatment outcome. The purpose of this study was to analyze the prescribing patterns of anti-asthma drugs by pediatricians, family physicians and other practitioners. METHODS: Data for a total of 225,537 anti-asthma prescriptions were collected from the National Health Insurance Research Database for the period from January 1, 2024 to March 31, 2002. These medications included inhaled and oral adrenergics, inhaled and oral corticosteroids, xanthine derivatives, and leukotriene receptor antagonists prescribed by general pediatricians, family physicians and physicians in other disciplines. RESULTS: Oral beta2-agonist was the most commonly prescribed drug used as monotherapy, with prescription rates of 70.4%, 46.9% and 58.0% by pediatricians, family physicians and other physicians, respectively. A xanthine derivative was the next most commonly prescribed monotherapy. Oral corticosteroid combined with oral beta2-agonist, followed by oral beta2-agonist combined with a xanthine derivative were the two most commonly prescribed dual-agent combined therapies by all three physician categories. The prescription rate for inhaled corticosteroid monotherapy was 7.8% by pediatricians, 5.6% by family physicians, and 8.0% by other physicians. The prescription rate for inhaled adrenergic was the highest in family physicians (14.9%), followed by the other physicians (7.2%), and was lowest in pediatricians (3.1%). CONCLUSION: Pediatricians and family physicians appeared to share similar opinions on the medical management of children with asthma in that both most commonly prescribed oral beta2-agonists and xanthine derivatives, either alone or in combination. Family physicians were least likely to prescribe an inhaled corticosteroid and most likely to prescribe an inhaled adrenergic agent.


Watanasomsiri A, Phipatanakul W. Comparison of nebulized ipratropium bromide with salbutamol vs salbutamol alone in acute asthma exacerbation in children. Ann Allergy Asthma Immunol. 2006 May;96(5):701-6.
Department of Pediatrics,
Thammasat Chalerm Prakiat Hospital, Thammasat University Medical School, Pathumthani, Thailand.

BACKGROUND: Despite multiple doses of beta2-agonists in the treatment of acute asthma exacerbation, significant residual airways obstruction often remains. OBJECTIVE: To determine whether the addition of inhaled ipratropium bromide to salbutamol provides improvement in lung function and clinical asthma symptoms in young children with acute asthma exacerbation. METHODS: This study was a prospective, double-blind randomized control trial of children aged 3 to 15 years who presented with an acute asthma exacerbation at the emergency department or outpatient clinic of Thammasat University Hospital, Pathumthani, Thailand, between September 2001 and February 2003. Subjects were randomized to receive 3 doses of nebulized salbutamol mixed with isotonic sodium chloride solution (control) or ipratropium bromide (treatment) every 20 minutes. Additional doses of salbutamol were given every 30 minutes as needed. Asthma outcome measures were evaluated 40, 70, 100, and 120 minutes after baseline. Primary outcomes were the differences in percent change in asthma clinical score and percent change in peak expiratory flow rate (PEFR) from baseline. Secondary outcomes included change in percent predicted PEFR. RESULTS: Of 74 children randomized and enrolled in the trial, 71 had complete data for analysis. Thirty-three children were in the control group and 38 were in the treatment group. Both the percent change in PEFR and the change in percent predicted PEFR at any time were higher in the treatment group, but these findings were not statistically significantly different. The number of subjects with at least a 100% percent predicted PEFR at any time point was greater in the treatment group. CONCLUSION: Although this study did not demonstrate a significant advantage in clinical score and PEFR, the trend toward additional effect of ipratropium bromide was consistent with previous studies.


Zwerneman K.  End-tidal carbon dioxide monitoring: a VITAL sign worth watching. Crit Care Nurs Clin North Am. 2006 Jun;18(2):217-25, xi. Review.
Neurology Service,
Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75228, USA.

Capnography is the monitoring of end-tidal carbon dioxide in waveform and numeric display. For this technology to be useful, the critical care nurse must have a clear understanding of the normal capnography waveform and what the alterations in this waveform represent. The critical care nurse can use this information to plan patient care interventions with other critical care team members and to adjust care based on the patient's response. End-tidal carbon dioxide physiology, normal waveforms, abnormal waveforms, and clinical aspects of capnography monitoring are included.

Diagnosis, Diagnostics, Immunodiagnosis, Immunodiagnostics:

14651.  Al-Shawwa B, Al-Huniti N, Titus G, Abu-Hasan M. Hypercholesterolemia is a potential risk factor for asthma. J Asthma. 2006 Apr;43(3):231-3.

14652.  Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, Passariello A, Manguso F, Morelli L, Guarino A; Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP). Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics. 2006 May;117(5):e817-20.

14653.  Christopher KL. Understanding vocal cord dysfunction: a step in the right direction with a long road ahead.Chest. 2006 Apr;129(4):842-3.

14654.  Cockcroft DW, Davis BE. Deep inhalation bronchoprotection in asthma: correlation with airway responsiveness. J Allergy Clin Immunol. 2006 Apr;117(4):951-2.

14655.  Cunha BA. The atypical pneumonias: clinical diagnosis and importance. Clin Microbiol Infect. 2006 May;12 Suppl 3:12-24. Review.

14656.  Delfino RJ. Who are the children with asthma most susceptible to air pollution? Am J Respir Crit Care Med. 2006 May 15;173(10):1054-5.

14657.  Dinakar C, Simon S. The link between the Hippocratic Oath and evidence-based medicine. Ann Allergy Asthma Immunol. 2006 Apr;96(4):511-3.

14658.  Eschenauer GA, Regal RE, DePestel DD. Antibiotic allergy.N Engl J Med. 2006 May 25;354(21):2293-4.

14659.  Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma.Arch Dis Child. 2006 Apr;91(4):334-9.     Review.

14660.  Heraghty JL, Henderson AJ. Highlights in asthma 2005. Arch Dis Child.2006 May;91(5):422-5. Review. 

14661.  Kanter RK, Moran JR. Recent trends in pediatric hospitalization in New York state. J Pediatr. 2006 May;148(5):637-641.

14662.  Kraft M, Hamid Q.  Mycoplasma in severe asthma. J Allergy Clin Immunol. 2006 May;117(5):1197-8.

14663.  Kugelman A, Shaoul R, Goldsher M, Srugo I. Persistent cough and failure to thrive: a presentation of foreign body aspiration in a child with asthma. Pediatrics. 2006 May;117(5):e1057-60. 

14664.  Kuzucu A.  Parasitic diseases of the respiratory tract. Curr Opin Pulm Med. 2006 May;12(3):212-21. Review.

14665.  Kwon NH, Oh MJ, Min TH, Lee BJ, Choi DC. Causes and clinical features of subacute cough. Chest. 2006 May;129(5):1142-7.

14666.  Linday LA. Nutritional supplements and pediatric upper respiratory tract illnesses. J Allergy Clin Immunol. 2006 Apr;117(4):953-4; author reply 954.

14667.  Niggemann B, Heine RG.  Who should manage infants and young children with food induced symptoms? Arch Dis Child. 2006 May;91(5):379-82.

14668.  Putland M, Kerr D, Kelly AM. Adverse events associated with the use of intravenous epinephrine in emergency department patients presenting with severe asthma. Ann Emerg Med. 2006 Jun;47(6):559-63.

14669.  Raherison C, Abouelfath A, Le Gros V, Taytard A, Molimard M. Underdiagnosis of nocturnal symptoms in asthma in general practice. J Asthma. 2006 Apr;43(3):199-202.

14670.     Rowe BH, Camargo CA Jr. Emergency department treatment of severe acute asthma. Ann Emerg Med. 2006 Jun;47(6):564-6. 

14671.     Siddiqui AM, Bardapurkar JS, Patil VP. Oxidant and antioxidants in bronchial asthma. Indian Med Gazette 2005, 139(5), 174-7.

14672.  Weinberger M.  Exercise induced dyspnoea: if not asthma, then what? Arch Dis Child. 2006 Jun;91(6):543-4.

14673.  Yasmeen S, Romano PS, Schembri ME, Keyzer JM, Gilbert WM.  Accuracy of obstetric diagnoses and procedures in hospital discharge data. Am J Obstet Gynecol. 2006 Apr;194(4):992-1001.


14651.  Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med. 2006 May 11;354(19):1998-2005.

14652.  Brightling CE.  Clinical applications of induced sputum. Chest. 2006 May;129(5):1344-8. Review.

14653.  Burns SM. Ventilating patients with acute severe asthma: what do we really know? AACN Adv Crit Care. 2006 Apr-Jun;17(2):186-93. Review.

14654.  Cox G, Miller JD, McWilliams A, Fitzgerald JM, Lam S. Bronchial thermoplasty for asthma. Am J Respir Crit Care Med. 2006 May 1;173(9):965-9.

14655.  Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006 May;117(5):1021-35. 

14656.  Donohue JF, Fromer L.  Long-acting beta-agonists role in asthma management. J Fam Pract. 2006 Apr;Suppl:1-6. Review.

14657.  Glassroth J. The role of long-acting beta-agonists in the management of asthma: analysis, meta-analysis, and more analysis. Ann Intern Med. 2006 Jun 20;144(12):936-7. 

14658.  Harmanci K, Bakirtas A, Turktas I, Degim T. Oral montelukast treatment of preschool-aged children with acute asthma. Ann Allergy Asthma Immunol. 2006 May;96(5):731-5. 

14659.  Hermansen MN, Nielsen KG, Buchvald F, Jespersen JJ, Bengtsson T, Bisgaard H.  Acute relief of exercise-induced bronchoconstriction by inhaled formoterol inchildren with persistent asthma. Chest. 2006 May;129(5):1203-9. 

14660.  Heymann WR.  Intramuscular triamcinolone. J Am Acad Dermatol. 2006 May;54(5):866-7. 

14661.  Johnston SL, Blasi F, Black PN, Martin RJ, Farrell DJ, Nieman RB; TELICAST Investigators.  The effect of telithromycin in acute exacerbations of asthma. N Engl J Med. 2006 Apr 13;354(15):1589-600. 

14662.  Karagiannidis C, Hense G, Rueckert B, Mantel PY, Ichters B, Blaser K, Menz G, Schmidt-Weber CB. High-altitude climate therapy reduces local airway inflammation and modulates lymphocyte activation. Scand J Immunol. 2006 Apr;63(4):304-10. 

14663.  Koopmans JG, Lutter R, Jansen HM, van der Zee JS.  Adding salmeterol to an inhaled corticosteroid: long term effects on bronchial inflammation in asthma. Thorax. 2006 Apr;61(4):306-12.

14664.  Lipworth B. Phosphodiesterase type 4 inhibitors for asthma: a real breakthrough or just expensive theophylline? Ann Allergy Asthma Immunol. 2006 May;96(5):640-2.

14665.  Little FF. Treating acute asthma with antibiotics--not quite yet. N Engl J Med. 2006 Apr 13;354(15):1632-4.

14666.  Palmer K, Burks W.  Current developments in peanut allergy. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):202-6. Review. 

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