Complementary Systems of Medicine

(Acupressure, Acupuncture, Alternative Medicine, Aroma therapy, Ayurveda, Complementary Medicine, Herbal Medicine, Homeopathy, Hypnotherapy, Magnetotherapy, Naturopathy, Pranic Healing, Reflexology, Reiki, Siddha, Traditional Medicine, Unani, Yoga & Meditation)    

January 2006

Some Selected Abstract::


Broom A. Medical specialists' accounts of the impact of the Internet on the doctor/patient relationship. Health (London). 2005 Jul;9(3):319-38.
School of Healthcare, University of Leeds, UK.
In the context of health service delivery, deprofessionalization denotes a trend towards a demystification of medical expertise and increasing lay scepticism about health professionals, suggesting a decline in the power and status of the medical profession. This process has been linked to increasing consumerism, the rise of complementary medicine and the emergence of the Internet. Drawing on data from in-depth interviews with prostate cancer specialists, this article explores their experiences of the Internet user within the context of the medical consultation. Results suggest that the deprofessionalization thesis is inadequate for capturing the complex and varying ways in which specialists view, and respond to, the Internet-informed patient. It is argued that the ways in which these specialists are adapting to the Internet and the Internet user should be viewed as strategic responses, rather than reflecting a breakdown in their authority or status. 'Enlistment' and 'translation' are presented as useful conceptual tools for understanding specialists' experiences of the Internet.


Chen HM, Chang FY, Hsu CT. Effect of acupressure on nausea, vomiting, anxiety and pain among post-cesarean section women in Taiwan.  Kaohsiung J Med Sci. 2005 Aug;21(8):341-50.
Department of Nursing, Chung Hwa College of Medical Technology, 89 Wen-Hwa 1st Road, Jen Te Hsiang, Tainan Hsien, Taiwan.
The purpose of this study was to examine the effectiveness of acupressure for controlling post-cesarean section (CS) symptoms, such as nausea and vomiting, anxiety perception and pain perception. A total of 104 eligible participants were recruited by convenience sampling of operating schedules at two hospitals. Participants assigned to the experimental group received acupressure, and those assigned to the control group received only postoperative nursing instruction. The experimental group received three acupressure treatments before CS and within the first 24 hours after CS. The first treatment was performed the night before CS, the second was performed 2-4 hours after CS, and the third was performed 8-10 hours after CS. The measures included the Rhodes Index of Nausea and Vomiting, Visual Analog Scale for Anxiety, State-Trait Anxiety Inventory, Visual Analog Scale for Pain, and physiologic indices. Statistical methods included percentages, mean value with standard deviation, t test and repeated measure ANOVA. The use of acupressure reduced the incidence of nausea, vomiting or retching from 69.3% to 53.9%, compared with control group (95% confidence interval = 1.65-0.11; p = 0.040) 2-4 hours after CS and from 36.2% to 15.4% compared with control group (95% confidence interval = 0.59-0.02; p = 0.024) 8-10 hours after CS. Results indicated that the experimental group had significantly lower anxiety and pain perception of cesarean experiences than the control group. Significant differences were found in all physiologic indices between the two groups. In conclusion, the utilization of acupressure treatment to promote the comfort of women during cesarean delivery is strongly recommended.


Choi JH, Moon JS, Song R. Effects of Sun-style Tai Chi exercise on physical fitness and fall prevention in fall-prone older adults. J Adv Nurs. 2005 Jul;51(2):150-7.

Department of Nursing, Daewon Science College, Chungbuk, South Korea.
AIM: This paper reports a study to determine changes in the physical fitness (knee and ankle muscle strength, balance, flexibility, and mobility), fall avoidance efficacy, and fall episodes of institutionalized older adults after participating in a 12-week Sun-style Tai Chi exercise programme. BACKGROUND: Fall prevention has a high priority in health promotion for older people because a fall is associated with serious morbidity in this population. Regular exercise is effective in fall prevention for older adults because of improvements in strength and balance. Tai Chi exercise is considered to offer great potential for health promotion and rehabilitation, particularly in the maintenance of good mental and physical condition in older people. METHODS: A quasi-experimental design with a non-equivalent control group was used. Data were collected from September 2001 to January 2002. A total of 68 fall-prone older adults with a mean age of 77.8 years participated in the study, and 29 people in the Tai Chi group and 30 controls completed the post-test measures. The Tai Chi exercise programme was provided three times a week for 12 weeks in the experimental group. Data were analysed for group differences using t-tests. RESULTS: At post-test, the experimental group showed significantly improved muscle strength in knee and ankle flexors (P < 0.001) and extensors (P < 0.01), and improved flexibility (P < 0.01) and mobility (P < 0.001) compared with the control group. There was no significant group difference in fall episodes, but the relative risk ratio for the Tai Chi exercise group compared with the control group was 0.62. The experimental group reported significantly more confidence in fall avoidance than did the control group. CONCLUSION: The findings reveal that Tai Chi exercise programmes can safely improve physical strength and reduce fall risk for fall-prone older adults in residential care facilities.


Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005 Sep;12(9):684-701.
Department of Forensic Medicine, University of Freiburg, Albertstr. 9, 79104 Freiburg, Germany.
Zingiberis rhizoma is used as a broadspectrum antiemetic. We, therefore, conducted a comprehensive review of the literature to summarize the pharmacological and clinical effects of this popular plant material. Although clinical and experimental studies suggest that ginger has some antiemetic properties, clinical evidence beyond doubt is only available for pregnancy-related nausea and vomiting. Meta-analyses could not demonstrate the postoperative antiemetic effectiveness, and effect in motion sickness or nausea/vomiting of other ethiology. It also remains to be confirmed that proprietary ginger preparations are clinically useful to alleviate osteoarthritic or other pain, although there is no doubt that ginger constituents interfere with the inflammatory cascade and the vanilloid nociceptor. Ginger exerts in vitro antioxidative, antitumorigenic and immunomodulatory effects and is an effective antimicrobial and antiviral agent. Animal studies demonstrate effects on the gastrointestinal tract, the cardiovascular system, on experimental pain and fever, antioxidative, antilipidemic and antitumor effects, as well as central and other effects. The most relevant human pharmacological studies require a confirmatory study to exclude interaction of ginger preparations with platelet aggregation. Pharmacokinetic data are only available for [6]-gingerol and zingiberene. Preclinical safety data do not rule out potential toxicity, which should be monitored especially following ginger consumption over longer periods.


DiBenedetto M, Innes KE, Taylor AG, Rodeheaver PF, Boxer JA, Wright HJ, Kerrigan DC. Effect of a gentle Iyengar yoga program on gait in the elderly: an exploratory study. Arch Phys Med Rehabil. 2005 Sep;86(9):1830-7.
Department of Physical Medicine and Rehabilitation, University of Virginia, Charlottesville, 22908, USA.
OBJECTIVE: To determine if a tailored yoga program could improve age-related changes in hip extension, stride length, and associated indices of gait function in healthy elders, changes that have been linked to increased risk for falls, dependency, and mortality in geriatric populations. DESIGN: Single group pre-post test exploratory study. A 3-dimensional quantitative gait evaluation, including kinematic and kinetic measurements, was performed pre- and postintervention. Changes over time (baseline to postintervention) in primary and secondary outcome variables were assessed using repeated-measures analysis of variance. SETTING: Yoga exercises were performed in an academic medical center (group classes) and in the subjects' homes (yoga home-practice assignments). Pre- and postassessments were performed in a gait laboratory. PARTICIPANTS: Twenty-three healthy adults (age range, 62-83 y) who were naive to yoga were recruited; 19 participants completed the program. INTERVENTION: An 8-week Iyengar Hatha yoga program specifically tailored to elderly persons and designed to improve lower-body strength and flexibility. Participants attended two 90-minute yoga classes per week, and were asked to complete at least 20 minutes of directed home practice on alternate days. MAIN OUTCOME MEASURES: Peak hip extension, average anterior pelvic tilt, and stride length at comfortable walking speed. RESULTS: Peak hip extension and stride length significantly increased (F1,18=15.44, P<.001; F1,18=5.57, P=.03, respectively). We also observed a trend toward reduced average pelvic tilt (F1,18=4.10, P=.06); adjusting for the modifying influence of frequency of home yoga practice strengthened the significance of this association (adjusted F1,17=14.30, P=.001). Both the frequency and duration of yoga home practice showed a strong, linear, dose-response relationship to changes in hip extension and average pelvic tilt. CONCLUSIONS: Findings of this exploratory study suggest that yoga practice may improve hip extension, increase stride length, and decrease anterior pelvic tilt in healthy elders, and that yoga programs tailored to elderly adults may offer a cost-effective means of preventing or reducing age-related changes in these indices of gait function.


Dijoseph J, Cavendish R. Expanding the dialogue on prayer relevant to holistic care. Holist Nurs Pract. 2005 Jul-Aug;19(4):147-54; quiz 154-5.
St. Vincent's Hospital, Staten Island, NY 10314, USA.
Because prayer is the most frequently used spiritual practice, it is beneficial to address the relationship between prayer and spiritual care needs. Raising awareness among nurses of the meaning of prayer practices in healthcare settings may strengthen holistic care. This article presents a synthesis of nursing theory on prayer and spirituality for holistic care and attempts to expand an understanding of prayer practices related to traditions of increasingly diverse patients and caregivers. In addition, a 4-point guide for spiritual caregiving is presented to help nurses address human responses in the spiritual domain.


Dresang LT, Brebrick L, Murray D, Shallue A, Sullivan-Vedder L. Family medicine in Cuba: community-oriented primary care and complementary and alternative medicine. J Am Board Fam Pract. 2005 Jul-Aug;18(4):297-303.
University of Wisconsin Medical School, St. Luke's Family Practice Residency, Milwaukee, USA.
Family physicians in Cuba and the United States operate within very different health systems. Cuba's health system is notable for achieving developed country health outcomes despite a developing country economy. The authors of this study traveled to Cuba and reviewed the literature to investigate which practices of Cuban family physicians might be applicable for US family physicians wishing to learn from the Cuban experience. We found that community-oriented primary care (COPC) and complementary and alternative medicine (CAM) are well developed within the Cuban medical system. Because COPC and CAM are already recommended by US family medicine professional bodies, US family physicians may want to learn from the Cuban experience and perhaps incorporate elements into their individual practices.


Eller LS, Corless I, Bunch EH, Kemppainen J, Holzemer W, Nokes K, Portillo C, Nicholas P. Self-care strategies for depressive symptoms in people with HIV disease. J Adv Nurs. 2005 Jul;51(2):119-30.
Rutgers, The State University of New Jersey College of Nursing, New Jersey 07102, USA.
AIM: This paper reports a study with people living with HIV to examine the experience of depressive symptoms, self-care symptom management strategies, symptom outcomes in response to those strategies, and sources from which the strategies were learned. BACKGROUND: Depressive symptoms are common, under-diagnosed and under-treated in people living with HIV. These symptoms have been associated with lower medication adherence, risky behaviours and poorer health outcomes. METHODS: The study was based on the model of symptom management developed by the University of California San Francisco School of Nursing Symptom Management Faculty. Thirty-four HIV+ men and women from a larger study of symptom self-care strategies (n = 422) reported experiencing depressive symptoms. Data were collected from this subset on the Web, by mail and in-person using the critical incident technique. RESULTS: Depressive symptoms were described using 80 words and phrases clustered into eight categories: futility, sadness, loneliness/isolation, fatigue, fear/worry, lack of motivation, suicidal thoughts and other. A total of 111 self-care strategies were coded into six categories: practising complementary/alternative therapies, talking to others, using distraction techniques, using antidepressants, engaging in physical activity, and using denial/avoidant coping. Sources of information for strategies used were trial and error (31%), healthcare providers (28%), family and friends (20%), classes/reading (8%), clergy (8%), support groups (4%) and other (3%). Overall, 92% of the self-care strategies used were reported as helpful, 4% were sometimes helpful and 4% were not helpful. CONCLUSIONS: People living with HIV use numerous effective self-care strategies to manage depressive symptoms. Further study is needed to validate the use of these strategies across populations, to standardize dose, duration and frequency, and to measure their effectiveness.


Emmons SL, Otto L.Acupuncture for overactive bladder: a randomized controlled trial. Obstet Gynecol. 2005 Jul;106(1):138-43.
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, 97239, USA.
OBJECTIVE: To compare acupuncture treatment for overactive bladder with urge incontinence with a placebo acupuncture treatment. METHODS: Eighty-five women enrolled in this randomized, placebo-controlled trial. Women were randomly assigned to either receive an acupuncture treatment expected to improve their bladder symptoms, or a placebo acupuncture treatment designed to promote relaxation. They underwent cystometric testing, completed a 3-day voiding diary, and completed the urinary distress inventory and incontinence impact questionnaire, validated quality-of-life inventories, before and after 4 weekly acupuncture treatments. The primary endpoint was number of incontinent episodes over 3 days. Secondary endpoints included voiding frequency and urgency, cystometric bladder capacity, maximum voided volume, and the urinary distress inventory and incontinence impact questionnaire symptom scores. RESULTS: Seventy-four women completed all aspects of the study. Women in both treatment and placebo groups had significant decreases in number of incontinent episodes (59% for treatment, 40% for placebo) without a significant difference in the change between the groups. Women in the treatment group had a 14% reduction in urinary frequency (P = .013), a 30% reduction in the proportion of voids associated with urgency (P = .016), and a 13% increase in both maximum voided volume and maximum cystometric capacity (P = .01). Both groups also had an improvement in the urinary distress inventory and incontinence impact questionnaire scores (54% decrease for treatment, 30% decrease for placebo, P < .001 for the difference in change between the groups). CONCLUSION: Women who received 4 weekly bladder-specific acupuncture treatments had significant improvements in bladder capacity, urgency, frequency, and quality-of-life scores as compared with women who received placebo acupuncture treatments. LEVEL OF EVIDENCE: I.


Grigoleit HG, Grigoleit P. Gastrointestinal clinical pharmacology of peppermint oil. Phytomedicine. 2005 Aug;12(8):607-11.
In nine studies, 269 healthy subjects or patients underwent exposure to peppermint oil (PO) either by topical intraluminal (stomach or colon) or oral administration by single doses or 2 weeks treatment (n = 19). Methods used to detect effects were oro-cecal transit time by hydrogen expiration, total gastrointestinal transit time by carmine red method, gastric emptying time by radiolabelled test meal or sonography, direct observation of colonic motility or indirect recording through pressure changes or relieve of colonic spasms during barium enema examination. The dose range covered in single dose studies is 0.1-0.24ml of PO/subject. With one exception, which show an unexplained potentiation of neostigmine stimulated colon activity, all other studies result in effects, indicating a substantial spasmolytic effect of PO of the smooth muscles of the gastrointestinal tract. Pharmacokinetic studies reveal that fractionated urinary recovery of menthol is dependent on the kind of formulation used for the application of PO. Optimal pH triggered enteric coated formulations start releasing PO in the small intestine extending release over 10-12 h thus providing PO to the target organ in irritable bowel syndrome, i.e. the colon. The hypothesis is supported by anecdotal observations in patients with achlorhydria or ileostoma, respectively.


Klassen TP, Pham B, Lawson ML, Moher D. For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine. J Clin Epidemiol. 2005 Aug;58(8):763-8.
Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
OBJECTIVE: To compare the quality of reporting of reports randomized controlled trials (RCTs) published in English and in languages other than English (LOE), and to determine whether there were differences between conventional medicine (CM) and complementary and alternative medicine (CAM) reports. STUDY DESIGN AND SETTING: We examined more than 600 RCTs associated with 125 systematic reviews. We extracted characteristics of each RCT using a standardized data collection form. We assessed quality using the Jadad scale and the adequacy of allocation concealment. RESULTS: There were only minor differences in the quality of reports of RCTs published in English compared with other languages (median quality score of 3 vs. 2, P=.10), and the quality of reports of CAM RCTs was similar to the CM reports (median score of 3 vs. 2, P=.14). There was no effect of language of publication on quality of reporting for CM trials (median score of 2 vs. 2, P=.12). Among CAM trials, however, overall quality scores were higher for reports in English than for reports in other languages (median score of 3 vs. 2, P=.04). CONCLUSION: The overall quality of reports published in languages other than English is similar to that of English-language reports. Moreover, the overall quality of reporting of RCTs of CAM interventions is as good as that for CM interventions.


Kristal AR, Littman AJ, Benitez D, White E. Yoga practice is associated with attenuated weight gain in healthy, middle-aged men and women. Altern Ther Health Med. 2005 Jul-Aug;11(4):28-33.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash, USA.
BACKGROUND: Yoga is promoted or weight maintenance, but there is little evidence of its efficacy. OBJECTIVE: To examine whether yoga practice is associated with lower mean 10-year weight gain after age 45. PARTICIPANTS: Participants included 15,550 adults, aged 53 to 57 years, recruited to the Vitamin and Lifestyle (VITAL) cohort study between 2000 and 2002. MEASUREMENTS: Physical activity (including yoga) during the past 10 years, diet, height, and weight at recruitment and at ages 30 and 45. All measures were based on self-reporting, and past weight was retrospectively ascertained. METHODS: Multiple regression analyses were used to examined covariate-adjusted associations between yoga practice and weight change from age 45 to recruitment, and polychotomous logistic regression was used to examine associations of yoga practice with the relative odds of weight maintenance (within 5%) and weight loss (> 5%) compared to weight gain. RESULTS: Yoga practice for four or more years was associated with a 3.1-lb lower weight gain among normal weight (BMI < 25) participants [9.5 lbs versus 12.6 Ibs] and an 18.5-lb lower weight gain among overweight participants [-5.0 lbs versus 13.5 Ibs] (both P for trend <.001). Among overweight individuals, 4+ years of yoga practice was associated with a relative odds of 1.85 (95% confidence interval [CI] 0.63-5.42) for weight maintenance (within 5%) and 3.88 (95% Cl 1.30-9.88) for weight loss (> 5%) compared to weight gain (P for trend .026 and .003, respectively). CONCLUSIONS: Regular yoga practice was associated with attenuated weight gain, most strongly among individuals who were overweight. Although causal inference from this observational study is not possible, results are consistent with the hypothesis that regular yoga practice can benefit individuals who wish to maintain or lose weight.


Krucoff MW, Crater SW, Gallup D, Blankenship JC, Cuffe M, Guarneri M, Krieger RA, Kshettry VR, Morris K, Oz M, Pichard A, Sketch MH Jr, Koenig HG, Mark D, Lee KL. Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study. Lancet. 2005 Jul 16-22;366(9481):211-7.
Duke Clinical Research Institute, Durham, NC 27705, USA.
BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We undertook a multicentre, prospective trial of two such practices: intercessory prayer and music, imagery, and touch (MIT) therapy. METHODS: 748 patients undergoing percutaneous coronary intervention or elective catheterisation in nine USA centres were assigned in a 2x2 factorial randomisation either off-site prayer by established congregations of various religions or no off-site prayer (double-blinded) and MIT therapy or none (unmasked). The primary endpoint was combined in-hospital major adverse cardiovascular events and 6-month readmission or death. Prespecified secondary endpoints were 6-month major adverse cardiovascular events, 6 month death or readmission, and 6-month mortality. FINDINGS: 371 patients were assigned prayer and 377 no prayer; 374 were assigned MIT therapy and 374 no MIT therapy. The factorial distribution was: standard care only, 192; prayer only, 182; MIT therapy only, 185; and both prayer and MIT therapy, 189. No significant difference was found for the primary composite endpoint in any treatment comparison. Mortality at 6 months was lower with MIT therapy than with no MIT therapy (hazard ratio 0.35 (95% CI 0.15-0.82, p=0.016). INTERPRETATION: Neither masked prayer nor MIT therapy significantly improved clinical outcome after elective catheterisation or percutaneous coronary intervention.


Lee MS, Kim MK, Ryu H. Qi-training (qigong) enhanced immune functions: what is the underlying mechanism? Int J Neurosci. 2005 Aug;115(8):1099-104.
Center for Integrative Medicine, Institute of Medical Science, Wonkwang University, Iksan, Republic of Korea.
The authors observed that Qi-training enhances immune function and modulates neurohormone concentrations. The exact signal and priming mechanism for enhanced neutrophil function by Qi-training has not yet been demonstrated. This study investigated the effect of Qi-training on intracellular signaling leading to the enhancement of immune function. The growth hormone (GH) concentrations and O2- production by neutrophils (PMNs) was significantly increased after 1 h of Qi-training compared with the basal state. To verify that endogenous GH mediates the priming of PMNs, serum obtained from elderly subjects in the basal state and after Qi-training was incubated with neutrophils isolated from young subjects for 60 min and triggered with N-formyl-1-methionyl-1-leucyl-1-phenylalanine (fMLP). Significant O2- production was observed in the PMNs incubated with serum collected after a Qi-training (p < .05). On the other hand, the priming effect on the PMNs was abolished in Qi-training sera depleted of endogenous GH with anti-human GH polyclonal antibody (p < .01) and the tyrosine kinase inhibitor, genistein (p < .01). The authors suggest that the endogenous GH released during and immediately after Qi-training mediates the priming events through tyrosine kinase activation in PMNs.


Mehling WE, Hamel KA, Acree M, Byl N, Hecht FM. Randomized, controlled trial of breath therapy for patients with chronic low-back pain. Altern Ther Health Med. 2005 Jul-Aug;11(4):44-52.
Osher Center for Integrative Medicine, Department of Family and Community Medicine, University of California, San Francisco, USA.
CONTEXT: Patients suffering from chronic low back pain (cLBP) are often unsatisfied with conventional medical care and seek alternative therapies. Many mind-body techniques are said to help patients with low back pain by enhancing body awareness, which includes proprioception deficit in cLBP, but have not been rigorously studied in cLBP. Breath therapy is a western mind-body therapy integrating body awareness, breathing, meditation, and movement. Preliminary data suggest benefits from breath therapy for proprioception and low back pain. OBJECTIVE: To assess the effect of breath therapy on cLBP. DESIGN: Randomized, controlled trial. SETTING: Academic medical center. PARTICIPANTS: Thirty-six patients with cLBP. INTERVENTIONS: Six to eight weeks (12 sessions) of breath therapy versus physical therapy. MAIN OUTCOME MEASURES: Pain by visual analog scale (VAS), function by Roland Scale, overall health by Short Form 36 (SF-36) at baseline, six to eight weeks, and six months. Balance as a potential surrogate for proprioception and body-awareness measured at the beginning and end of treatment. RESULTS: Pre- to post-intervention, patients in both groups improved in pain (VAS: -2.7 with breath therapy, -2.4 with physical therapy; SF-36: +14.9 with breath therapy and +21.0 with physical therapy). Breath therapy recipients improved in function (Roland: -4.8) and in the physical and emotional role (SF-36: +15.5 and 14.3). Physical therapy recipients improved in vitality (SF-36: +15.0). Average improvements were not different between groups. At six to eight weeks, results showed a trend favoring breath therapy; at six-months, a trend favoring physical therapy. Balance measures showed no improvements and no correlations with other outcomes. CONCLUSIONS: Patients suffering from cLBP improved significantly with breath therapy. Changes in standard low back pain measures of pain and disability were comparable to those resulting from high-quality, extended physical therapy. Breath therapy was safe. Qualitative data suggested improved coping skills and new insight into the effect of stress on the body as a result of breath therapy. Balance measures did not seem to be valid measures of clinical change in patients' cLBP.


Sandel SL, Judge JO, Landry N, Faria L, Ouellette R, Majczak M. Dance and movement program improves quality-of-life measures in breast cancer survivors. Cancer Nurs. 2005 Jul-Aug;28(4):301-9.
MidState Medical Center, Meriden, CT 06450, USA.
A pilot research study was conducted at 2 cancer centers in Connecticut to determine the effect of a dance and movement program on quality of life and shoulder function in breast cancer survivors treated within the prior 5 years. Thirty-five women completed the trial that included a 12-week intervention, using The Lebed Method, Focus on Healing Through Movement and Dance. The study design was a randomized control trial with a wait list control group crossover to active treatment in weeks 13 to 25, with the treatment group receiving the program in weeks 1 to 12, and no program in weeks 13 to 25. Outcome measures were the Breast Cancer Quality of Life (FACT-B), Shoulder range of motion (ROM), and Body Image Scale. FACT-B significantly improved in the intervention group at 13 weeks from 102.0 +/- 15.8 to 116.7 +/- 16.9, compared to the wait list group 108.1 +/- 16.4 to 107.1 +/- 21.3 (time x group effect, P = .008). During the crossover phase, the FACT-B score increased in the wait list group and was stable in the treatment group. The overall effect of the training at 26 weeks was significant (time effect, P = .03), and the order of training was also significant (P = .015). Shoulder ROM increased in both groups at 13 weeks--15 degrees and 8 degrees in the intervention and wait list groups (Time effect, P = .03; time x group, P = .58). Body Image improved similarly in both groups at 13 weeks (time effect, P = .001; time x group, P = .25), and at 26 weeks. There was no significant effect of the order of training for these outcome measures. A dance movement program that addressed the physical and emotional needs of women following treatment for breast cancer substantially improved a breast cancer-specific quality-of-life measure. Larger studies are justified to determine the acceptability of this therapy as part of the continuum of care for breast cancer survivors.


Sattin RW, Easley KA, Wolf SL, Chen Y, Kutner MH. Reduction in fear of falling through intense tai chi exercise training in older, transitionally frail adults. J Am Geriatr Soc. 2005 Jul;53(7):1168-78.
National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
OBJECTIVES: To determine whether an intense tai chi exercise program could reduce fear of falling better than a wellness education (WE) program in older adults who had fallen previously and meet criteria for transitioning to frailty. DESIGN: Cluster-randomized, controlled trial of 48 weeks' duration. SETTING: Ten matched pairs of congregate living facilities in the greater Atlanta area. PARTICIPANTS: Sample of 291 women and 20 men, aged 70 to 97. MEASUREMENTS: Activity-related fear of falling using the Activities-Specific Balance Confidence Scale (ABC) and the Fall Efficacy Scale at baseline and every 4 months for 1 year. Demographics, time to first fall and all subsequent falls, functional measures, Centers for Epidemiologic Studies Depression Scale, medication use, level of physical activity, comorbidities, and adherence to interventions. RESULTS: Mean ABC was similar in both cohort groups at the time of randomization but became significantly higher (decreased fear) in the tai chi cohort at 8 months (57.9 vs 49.0, P<.001) and at study end (59.2 vs 47.9, P<.001). After adjusting for covariates, the mean ABC after 12 months of intervention was significantly greater in the tai chi group than in the WE group, with the differences increasing with time (mean difference at 12 months=9.5 points, 95% confidence interval=4.8-14.2, P<.001). CONCLUSION: Tai chi led to a significantly greater reduction in fear of falling than a WE program in transitionally frail older adults. The mean percentage change in ABC scores widened between tai chi and WE participants over the trial period. Tai chi should be considered in any program designed to reduce falling and fear of falling in transitionally frail older adults.


Staples JK, Gordon JS. Effectiveness of a mind-body skills training program for healthcare professionals. Altern Ther Health Med. 2005 Jul-Aug;11(4):36-41.
Center for Mind-Body Medicine, Washington, DC, USA.
CONTEXT: Because of the increased use and benefits of mind-body therapies, it is important that healthcare professionals receive training in these modalities. OBJECTIVE: To determine whether healthcare professionals who attended the Center for Mind-Body Medicine's training program were incorporating mind-body skills into their professional or personal practices and whether they had a greater sense of life satisfaction. DESIGN: Repeated measures analysis. SETTING: Annual training programs were held in hotels and conference centers in the US. PARTICIPANTS: Four hundred fifty-one healthcare professionals attended the programs from 1998 to 2001. Two hundred fifty-nine completed the one-year follow-up survey, and 307 completed the well-being survey. INTERVENTION: The week-long program included didactic and experiential training in biofeedback, meditation, autogenics, imagery, and movement/exercise, as well as self-expression in small groups through drawings, written exercises, and genograms. MAIN OUTCOME MEASURES: Questionnaires on previous training and personal and professional use of mind-body approaches were administered before and one year after the program. The Existential Well-Being (EWB) scale also was administered before and immediately after the training. RESULTS: There was a significant increase in the personal use of mind-body skills and the number of participants who were teaching their clients to use all modalities and a significant decrease in the number of participants who were referring clients to others for training. Participants also had significantly higher life satisfaction scores after the program. CONCLUSION: This professional training program was effective in promoting the personal and professional use of mind-body skills and in enhancing the personal fulfillment of trainees.


van Tulder MW, Furlan AD, Gagnier JJ. Complementary and alternative therapies for low back pain. Best Pract Res Clin Rheumatol. 2005 Aug;19(4):639-54.
Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
The support for the principles of evidence-based medicine has increased within the field of complementary and alternative medicine (CAM). The objective of this chapter is to determine the effectiveness of CAM therapies compared to placebo, no intervention, or other interventions for acute/subacute and chronic non-specific low back pain (LBP). Results from Cochrane reviews on acupuncture, botanical medicine, massage, neuroreflexotherapy, and spinal manipulation have been used. The results showed that acupuncture is more effective than no treatment or sham treatment for chronic LBP but that there are no differences in effectiveness compared with other conventional therapies. Specific botanical medicines can be effective for acute episodes of chronic non-specific LBP in terms of short-term improvement in pain and functional status; long-term efficacy was not assessed. Massage seems more beneficial than sham treatment for chronic non-specific LBP but effectiveness compared with other conventional therapies is inconclusive. Neuroreflexotherapy appears to be more effective than sham treatment or standard care for chronic non-specific LBP. Spinal manipulation was more effective than sham manipulation or ineffective therapies, and equally effective as other conventional therapies. In summary, the results on CAM therapies for (acute episodes of) chronic LBP are promising but more evidence on the relative cost-effectiveness compared to conventional treatments is needed.


Wall RB. Tai Chi and mindfulness-based stress reduction in a Boston Public Middle School. J Pediatr Health Care. 2005 Jul-Aug;19(4):230-7.
This article provides a description of a clinical project that used combined Tai Chi and mindfulness-based stress reduction as an educational program. The 5-week program demonstrated that sustained interest in this material in middle school-aged boys and girls is possible. Statements the boys and girls made in the process suggested that they experienced well-being, calmness, relaxation, improved sleep, less reactivity, increased self-care, self-awareness, and a sense of interconnection or interdependence with nature. The curriculum is described in detail for nurses, teachers, and counselors who want to replicate this type of instruction for adolescent children. This project infers that Tai Chi and mindfulness-based stress reduction may be transformational tools that can be used in educational programs appropriate for middle school-aged children. Recommendations are made for further study in schools and other pediatric settings.


Yesilada E. Past and future contributions to traditional medicine in the health care system of the Middle-East. J Ethnopharmacol. 2005 Aug 22;100(1-2):135-7.
Faculty of Pharmacy, Yeditepe University, 34755 Istanbul, Turkey.
Due to the rich cultural heritage and relatively rich flora, a wealth of knowledge on traditional and folk medicine has been accumulated in the Middle-East. However, except Turkey, the number of ethnobotanical field studies is few and mainly focused on Unani medicine, which is practised widespread in the southern communities. Urgent scientific field surveys should be conducted among the native people in order to document the wealth of knowledge on folk medicine, other than Unani medicine, before it will be lost by the erosive effects of modernization.


13588.  Abbott A. Survey questions safety of alternative medicine. Nature. 2005 Aug 18;436(7053):898.

13589.  Abramson RJ. Five-element acupuncture: a body-mind-spirit system of healing: an interview with Robert J. Abramson, DDS, MD, MAc. Interview by Sheldon Lewis. Adv Mind Body Med. 2005 Summer;21(2):19-21.

13590.   Adler UC. The influence of childhood infections and vaccination on the development of atopy: a systematic review of the direct epidemiological evidence. Homeopathy. 2005 Jul;94(3):182-95. Review.

13591.  An BJ, Kwak JH, Park JM, Lee JY, Park TS, Lee JT, Son JH, Jo C, Byun MW. Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin. Dermatol Surg. 2005 Jul;31(7 Pt 2):848-54; discussion 854. Review.

13592.  Anderson RU, Wise D, Sawyer T, Chan C. Integration of myofascial trigger point release and paradoxical relaxation training treatment of chronic pelvic pain in men. J Urol. 2005 Jul;174(1):155-60.

13593.  Bakri IM, Douglas CW. Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol. 2005 Jul;50(7):645-51.

13594.  Bressler R. Herb-drug interactions. St. John's wort and prescription medications. Geriatrics. 2005 Jul;60(7):21-3. Review.

13595.  Bressler R. Herb-drug interactions: interactions between ginseng and prescription medications. Geriatrics. 2005 Aug;60(8):16-7. Review.

13596.  Brinkhaus B, Hentschel C, Von Keudell C, Schindler G, Lindner M, Stutzer H, Kohnen R, Willich SN, Lehmacher W, Hahn EG. Herbal medicine with curcuma and fumitory in the treatment of irritable bowel syndrome: a randomized, placebo-controlled, double-blind clinical trial. Scand J Gastroenterol. 2005 Aug;40(8):936-43.

13597.   Broom A. Medical specialists' accounts of the impact of the Internet on the doctor/patient relationship. Health (London). 2005 Jul;9(3):319-38.

13598.  Canning DA. Effect of alarm treatment on bladder storage capacities in monosymptomatic nocturnal enuresis. J Urol. 2005 Sep;174(3):1104.

13599.   Carroll C, Colston E, Conn W, Conrad H, Crouch S, Fischer S, Gabbard J, Hall A, Hart K, Kidd S, Lester M, Roberts M, Schmidt M, Tate N. Databits. Research for practice: complementary methods of pain control. Ky Nurse. 2005 Jul-Sep;53(3):34.

13600.   Chen HM, Chang FY, Hsu CT. Effect of acupressure on nausea, vomiting, anxiety and pain among post-cesarean section women in Taiwan. Kaohsiung J Med Sci. 2005 Aug;21(8):341-50.

13601.  Choi JH, Moon JS, Song R. Effects of Sun-style Tai Chi exercise on physical fitness and fall prevention in fall-prone older adults. J Adv Nurs. 2005 Jul;51(2):150-7.

13602.   Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005 Sep;12(9):684-701. Review.

13603.   Comar KM, Kirby DF. Herbal remedies in gastroenterology. J Clin Gastroenterol. 2005 Jul;39(6):457-68. Review.

13604.  DeLoach Walworth D. Procedural-support music therapy in the healthcare setting: a cost-effectiveness analysis. J Pediatr Nurs. 2005 Aug;20(4):276-84.

13605.   DiBenedetto M, Innes KE, Taylor AG, Rodeheaver PF, Boxer JA, Wright HJ, Kerrigan DC.  Effect of a gentle Iyengar yoga program on gait in the elderly: an exploratory study. Arch Phys Med Rehabil. 2005 Sep;86(9):1830-7.

13606.  Dijoseph J, Cavendish R. Expanding the dialogue on prayer relevant to holistic care. Holist Nurs Pract. 2005 Jul-Aug;19(4):147-54; quiz 154-5. Review.

13607.  DiNucci EM. Energy healing: a complementary treatment for orthopaedic and other conditions. Orthop Nurs. 2005 Jul-Aug;24(4):259-69. Review.

13608.  Dozza M, Chiari L, Horak FB. Audio-biofeedback improves balance in patients with bilateral vestibular loss. Arch Phys Med Rehabil. 2005 Jul;86(7):1401-3.

13609.  Dresang LT, Brebrick L, Murray D, Shallue A, Sullivan-Vedder L. Family medicine in Cuba: community-oriented primary care and complementary and alternative medicine. J Am Board Fam Pract. 2005 Jul-Aug;18(4):297-303.

13610.  Eller LS, Corless I, Bunch EH, Kemppainen J, Holzemer W, Nokes K, Portillo C, Nicholas P. Self-care strategies for depressive symptoms in people with HIV disease. J Adv Nurs. 2005 Jul;51(2):119-30.

13611.  Emmons SL, Otto L. Acupuncture for overactive bladder: a randomized controlled trial. Obstet Gynecol. 2005 Jul;106(1):138-43.

13612.  Eschiti VS. Planting seeds at Esalen: collaborative relationships in holistic healthcare. Beginnings. 2005 Summer;25(3):3, 17.

13613.  Forbes A, Jackson S, Walter C, Quraishi S, Jacyna M, Pitcher M. Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial. World J Gastroenterol. 2005 Jul 14;11(26):4040-4.

13614.  Grigoleit HG, Grigoleit P. Gastrointestinal clinical pharmacology of peppermint oil. Phytomedicine. 2005 Aug;12(8):607-11. Review.

13615.   Grigoleit HG, Grigoleit P. Peppermint oil in irritable bowel syndrome. Phytomedicine. 2005 Aug;12(8):601-6. Review.

13616.  Guarner EM. Erminia M. Guarneri, MD, FACC: pioneering integrative cardiologist. Interview by Karolyn A. Gazella. Altern Ther Health Med. 2005 Jul-Aug;11(4):64-70.

13617.  Haggans CJ, Regan KS, Brown LM, Wang C, Krebs-Smith J, Coates PM, Swanson CA.  Computer access to research on dietary supplements: a database of federally funded dietary supplement research. J Nutr. 2005 Jul;135(7):1796-9.

13618.  Haila S, Koskinen A, Tenovuo J. Effects of homeopathic treatment on salivary flow rate and subjective symptoms in patients with oral dryness: a randomized trial. Homeopathy. 2005 Jul;94(3):175-81.

13619.   Hassed C. An integrative approach to asthma. Aust Fam Physician. 2005 Jul;34(7):573-6. Review.

13620.  Hsu LM, Huang YS, Chang FY, Lee SD. 'Fat burner' herb, usnic acid, induced acute hepatitis in a family. J Gastroenterol Hepatol. 2005 Jul;20(7):1138-9.

13621.  Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). 2005 Jul;84(4):197-207.

13622.   Jager AK. Is traditional medicine better off 25 years later? J Ethnopharmacol. 2005 Aug 22;100(1-2):3-4.

13623.   Johnston G, Sladden M. Scabies: diagnosis and treatment. BMJ. 2005 Sep 17;331(7517):619-22. Review.

13624.  Kabat-Zinn J. Bringing mindfulness to medicine: an interview with Jon Kabat-Zinn, PhD. Interview by Karolyn Gazella. Adv Mind Body Med. 2005 Summer;21(2):22-7.

13625.   Kaplan SA. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. J Urol. 2005 Sep;174(3):1011.

13626.   Klassen TP, Pham B, Lawson ML, Moher D. For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine. J Clin Epidemiol. 2005 Aug;58(8):763-8.

13627.  Kotsirilos V. Complementary and alternative medicine. Part 2--evidence and implications for GPs. Aust Fam Physician. 2005 Aug;34(8):689-91. Review.

13628.   Kristal AR, Littman AJ, Benitez D, White E. Yoga practice is associated with attenuated weight gain in healthy, middle-aged men and women. Altern Ther Health Med. 2005 Jul-Aug;11(4):28-33.

13629.  Krucoff MW, Crater SW, Gallup D, Blankenship JC, Cuffe M, Guarneri M, Krieger RA, Kshettry VR, Morris K, Oz M, Pichard A, Sketch MH Jr, Koenig HG, Mark D, Lee KL.   Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomized study. Lancet. 2005 Jul 16-22;366(9481):211-7.

13630.  Kulkarni PH. Role of Ayurveda in prevention and the management of cancer. J natn Integrat med Ass 2005, 47(1), 7-11.

13631.  Lawson ML, Pham B, Klassen TP, Moher D. Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews. J Clin Epidemiol. 2005 Aug;58(8):777-84.

13632.  Lee MS, Kim MK, Ryu H. Qi-training (qigong) enhanced immune functions: what is the underlying mechanism? Int J Neurosci. 2005 Aug;115(8):1099-104.

13633.  Lewis S. Broken heart syndrome: perspectives from East and West. Adv Mind Body Med. 2005 Summer;21(2):3-5. Review.

13634.  Lunceford N, Gugliucci A. Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea. Fitoterapia. 2005 Jul;76(5):419-27.

13635.  McCaffrey R, Ruknui P, Hatthakit U, Kasetsomboon P. The effects of yoga on hypertensive persons in Thailand. Holist Nurs Pract. 2005 Jul-Aug;19(4):173-80.

13636.  Mehling WE, Hamel KA, Acree M, Byl N, Hecht FM. Randomized, controlled trial of breath therapy for patients with chronic low-back pain. Altern Ther Health Med. 2005 Jul-Aug;11(4):44-52.

13637.  Melchart D, Streng A, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, Pfaffenrath V, Hammes M, Hummelsberger J, Irnich D, Weidenhammer W, Willich SN, Linde K. Acupuncture in patients with tension-type headache: randomised controlled trial. BMJ. 2005 Aug 13;331(7513):376-82.

13638.  Mishra DK, Agarwal SC. Medicinal plant diversity of Maharashtra with special reference to endemism. Geophytology 2002, 32(1-2), 53-9.

13639.  Mohapatra HP, Rath SP. In vitro studies of Bacopa monnieri � an important medicinal plant with reference to its biochemical variations. Indian J expl Biol 2005, 43 (4), 373-6.

13640.  Oppel L, Beyerstein B, Hoshizaki D, Sutter M. Still concerned about CAM in undergraduate medical education. Can Fam Physician. 2005 Aug;51:1069-70.

13641.  Pilkington K, Kirkwood G, Rampes H, Fisher P, Richardson J. Homeopathy for depression: a systematic review of the research evidence. Homeopathy. 2005 Jul;94(3):153-63. Review.

13642.   Polubinski JP, West L. Implementation of a massage therapy program in the home hospice setting. J Pain Symptom Manage. 2005 Jul;30(1):104-6.

13643.  Prashad J Suri R. Treatment of hypertension in view of biochemistry in yoga practices. Act Cienc Indica � Chem 2004, 30(4), 269-72.

13644.  Ramachandran C, Rodriguez S, Ramachandran R, Raveendran Nair PK, Fonseca H, Khatib Z, Escalon E, Melnick SJ. Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3293-302.

13645.  Rawat AKS, Johri JK, Pushpangadan P. Quality control and standardization of traditional medicine. J scient ind Res 2005, 64(3), 229-33.

13646.  Robb-Nicholson C. By the way, doctor. I've heard you can lower your blood pressure by using a breathing device called Resperate. Do you know anything about this? Harv Womens Health Watch. 2005 Jul;12(11):8.

13647.  Sandel SL, Judge JO, Landry N, Faria L, Ouellette R, Majczak M. Dance and movement program improves quality-of-life measures in breast cancer survivors. Cancer Nurs. 2005 Jul-Aug;28(4):301-9.

13648.  Sattin RW, Easley KA, Wolf SL, Chen Y, Kutner MH. Reduction in fear of falling through intense tai chi exercise training in older, transitionally frail adults. J Am Geriatr Soc. 2005 Jul;53(7):1168-78.

13649.  Shang A, Huwiler-Muntener K, Nartey L, Juni P, Dorig S, Sterne JA, Pewsner D, Egger M.  Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet. 2005 Aug 27-Sep 2;366(9487):726-32.

13650.  Staples JK, Gordon JS. Effectiveness of a mind-body skills training program for healthcare professionals. Altern Ther Health Med. 2005 Jul-Aug;11(4):36-41.

13651.   Tadeg H, Mohammed E, Asres K, Gebre-Mariam T.  Antimicrobial activities of some selected traditional Ethiopian medicinal plants used in the treatment of skin disorders. J Ethnopharmacol. 2005 Aug 22;100(1-2):168-75.

13652.  Traynor NJ, Beattie PE, Ibbotson SH, Moseley H, Ferguson J, Woods JA. Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy. Toxicol Lett. 2005 Sep 15;158(3):220-4.

13653.  van Tulder MW, Furlan AD, Gagnier JJ. Complementary and alternative therapies for low back pain. Best Pract Res Clin Rheumatol. 2005 Aug;19(4):639-54. Review.

13654.  Vermani M, Milosevic I, Smith F, Katzman MA. Herbs for mental illness: effectiveness and interaction with conventional medicines. J Fam Pract. 2005 Sep;54(9):789-800. Review.

13655.   Vogel JH, Bolling SF, Costello RB, Guarneri EM, Krucoff MW, Longhurst JC, Olshansky B, Pelletier KR, Tracy CM, Vogel RA, Vogel RA, Abrams J, Anderson JL, Bates ER, Brodie BR, Grines CL, Danias PG, Gregoratos G, Hlatky MA, Hochman JS, Kaul S, Lichtenberg RC, Lindner JR, O'Rourke RA, Pohost GM, Schofield RS, Shubrooks SJ, Tracy CM, Winters WL Jr; American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol. 2005 Jul 5;46(1):184-221.

13656.  Wall RB. Tai Chi and mindfulness-based stress reduction in a Boston Public Middle School. J Pediatr Health Care. 2005 Jul-Aug;19(4):230-7.

13657.  Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hummelsberger J, Walther HU, Melchart D, Willich SN. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet. 2005 Jul 9-15;366(9480):136-43.

13658.  Woolhouse M. Migraine and tension headache--a complementary and alternative medicine approach. Aust Fam Physician. 2005 Aug;34(8):647-51. Review.

13659.  Wu CW, Kalunian KC. New developments in osteoarthritis. Clin Geriatr Med. 2005 Aug;21(3):589-601, vii. Review.

13660.  Yesilada E. Past and future contributions to traditional medicine in the health care system of the Middle-East. J Ethnopharmacol. 2005 Aug 22;100(1-2):135-7. Review.




April 2006

Some Selected Abstracts: 


Arora J, Kumar A, Ramji S. Effect of oil massage on growth and neurobehavior in very low birth weight preterm neonates. Indian Pediatr. 2005 Nov;42(11):1092-100.
Division of Neonatology, Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110 002, India.
OBJECTIVE: To study the effect of oil massage on growth and neurobehavior in preterm babies less than 1500 g. DESIGN: Randomized Controlled Trial. SETTING: Tertiary level neonatal unit of a teaching hospital. Subjects: Neonates with birth weight <1500 grams, gestation >37 weeks, receiving enteral feeds of at least 100 mL/kg/day and less than 10 days of age. OUTCOME VARIABLES: Primary-Weight gain 28 days after enrolment. Secondary-Neonatal neurobehavior, change in other anthropometry and serum triglycerides. METHODS: Eligible neonates were randomized to one of the three groups (a) massage with oil (b) massage without oil and (c) no massage. Weight, length, head circumference and triceps skin fold thickness were measured in the three groups at regular intervals. Serum triglyceride levels were measured at enrolment and at completion. Neurobehavior using Brazeltons Neonatal Behavior Assessment Scale (NBAS) was assessed at enrolment and after 10 days of intervention. RESULTS: Weight gain in the oil massage group (365.8 +/- 165.2g) was higher compared to the only massage group (290.0 +/- 150.2g) and no massage group (285.0 +/- 170.4g). This difference and the difference in other anthropometric parameters was not statistically significant. Serum triglycerides and neonatal neurobehavior were comparable in the three groups. CONCLUSION: Oil application may have a potential to improve weight gain among preterm very low birth weight neonates.


Beckerman M, Magadle R, Weiner M, Weiner P.The effects of 1 year of specific inspiratory muscle training in patients with COPD. Chest. 2005 Nov;128(5):3177-82.
Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel.

AIM: We assessed the long-term benefits of inspiratory muscle training (IMT) on inspiratory muscle strength, exercise capacity, the perception of dyspnea, quality of life, primary care use, and hospitalizations in patients with significant COPD. PATIENTS: Forty-two consecutive COPD patients with FEV(1) < 50% of predicted were randomized into a group that received IMT for 1 year, and a control group that received training with a very low load. RESULTS: There was a statistically significant increase in inspiratory muscle strength (at the end of the third month of training) as assessed by maximal inspiratory pressure (from 71 +/- 4.9 to 90 +/- 5.1 cm H(2)O [+/- SEM], p < 0.005) and 6-min walk distance (at the end of the third month of training; from 256 +/- 41 to 312 +/- 54 m; p < 0.005), a decrease in the mean Borg score during breathing against resistance (at the end of the ninth month of training), improvement in the health-related quality-of-life scores (at the end of the sixth month of training) in the training group but not in the control group. At the end of the training year, these changes were maintained; in addition, a decrease in primary health-care use and hospitalization days was observed. CONCLUSIONS: Our study shows that during IMT in patients with significant COPD, there is an increase in exercise capacity, improvement in quality of life, and decrease in dyspnea. Our study also provides evidence that long-term IMT can decrease the use of health services and hospitalization days.


Burns DS, Sledge RB, Fuller LA, Daggy JK, Monahan PO. Cancer patients' interest and preferences for music therapy. J Music Ther. 2005 Fall;42(3):185-99. 
Indiana University at IUPUI, USA. 

The reason for lack of routine integration of music therapy into healthcare may be that patients are not comfortable being involved in a music therapy intervention. Therefore, the goal of this study was to examine cancer patients' interest in and preferences for using 2 types of music therapy interventions, music-making and music listening. Sixty-five patients completed the Music Interest Survey in addition to standardized measures of coping, affect, anxiety, and fatigue. Results suggest adult cancer patients are interested in music therapy, especially mu
sic listening. Patient interest and preference were associated with negative affect, anxiety, age, perceived intervention-specific benefits, barriers, and self-efficacy. Findings highlight the need for a comprehensive assessment of patient needs and preferences prior to intervention


Chan AS, Ho YC, Cheung MC, Albert MS, Chiu HF, Lam LC.Association between mind-body and  cardiovascular exercises and memory in older adults. J Am Geriatr Soc. 2005 Oct;53(10):1754-0.
Department of Psychology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
OBJECTIVES: To compare the memory function of older adults who regularly practiced mind-body (MB) or cardiovascular (CV) exercises with that of those who did not engage in regular exercise. Older adults who engaged in both types of exercise were also included to examine the combined effects. DESIGN: Cross-sectional study between 2002 and 2003. SETTING: Older adults from a local community in Hong Kong. PARTICIPANTS: One hundred forty adults aged 56 and older. MEASUREMENTS: The Hong Kong List Learning Test was used to assess the memory of all participants. It is a clinically validated Chinese verbal-memory test that measures various aspects of memory processing, including learning, retention, and retrieval abilities. MB and CV exercises were defined using three dimensions: motion speed, emphasis on relaxing the mind, and conscious control of movement. RESULTS: Older adults who practiced MB or CV exercises demonstrated a similar level of memory function, and their learning and memory was better than that of individuals who did not exercise regularly. Those who practiced both types of exercises outperformed all other groups, even after corrected for the total hours of exercise. Although memory change across age was found in older adults who did not exercise, this trend was not observed in individuals who practiced MB exercises. CONCLUSION: Practicing both MB and CV exercises appears to have a combined effect that might help to preserve memory in older adults. In addition, MB exercises may be considered as an alternative training for older adults who cannot practice strenuous physical exercise.


Chubak J, Tworoger SS, Yasui Y, Ulrich CM, Stanczyk FZ, McTiernan A. Associations between reproductive and menstrual factors and postmenopausal androgen concentrations. J Womens Health (Larchmt). 2005 Oct;14(8):704-12.
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
BACKGROUND: Reproductive and menstrual characteristics, as well as high circulating estrogen and androgen concentrations, are associated with the risk of breast and ovarian cancer in postmenopausal women. To explore possible etiological relationships between menstrual and reproductive characteristics and cancer risk, we examined associations between menstrual and reproductive factors and serum concentrations of total testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S). METHODS: This study was conducted in 167 postmenopausal women, using data from the pre-randomization visit of an exercise clinical trial. Participants were sedentary, overweight/ obese, and not on hormone therapy. RESULTS: DHEA-S concentrations were 42% higher, total testosterone concentrations were 35% lower, and free testosterone concentrations were 23% lower in women with both ovaries removed compared with those with both remaining (p = 0.01, p = 0.01, and p = 0.03, respectively). Women who had used herbal therapy in the past had, on average, 25% higher concentrations of total and free testosterone than women who had never used these herbal therapies (p = 0.03 and p = 0.004, respectively). No other significant associations were detected. CONCLUSIONS: Overall, this study does not support the hypothesis that reproductive or menstrual factors, with the exception of oophorectomy status, are associated with postmenopausal androgen concentrations.


Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Murck H, Rosenbaum JF. A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol. 2005 Oct;25(5):441-7.
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA.
OBJECTIVE: This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine. METHOD: After a 1-week single-blind washout, patients with major depressive disorder diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were randomized to 12 weeks of double-blind treatment with LI-160 St John's wort extract (900 mg/d), fluoxetine (20 mg/d), or placebo. The 17-item Hamilton Rating Scale for Depression (HAMD-17) was the primary efficacy measure, and analysis of covariance was used to compare differences in end point HAMD-17 scores across the 3 treatment groups, treating the baseline HAMD-17 as the covariate. RESULTS: One hundred thirty-five patients (57% women; mean age, 37.3 +/- 11.0; mean HAMD-17, 19.7 +/- 3.2) were randomized to double-blind treatment and were included in the intent-to-treat analyses. Analysis of covariance analyses showed lower mean HAMD-17 scores at end point in the St John's wort group (n = 45; mean +/- SD, 10.2 +/- 6.6) compared with the fluoxetine group (n = 47; 13.3 +/- 7.3; P < 0.03) and a trend toward a similar finding relative to the placebo group (n = 43; 12.6 +/- 6.4; P = 0.096). There was also a trend toward higher rates of remission (HAMD-17 <8) in the St John's wort group (38%) compared with the fluoxetine group (30%) and the placebo group (21%). Overall, St John's wort appeared to be safe and well tolerated. CONCLUSION: St John's wort was significantly more effective than fluoxetine and showed a trend toward superiority over placebo. A (25%) smaller than planned sample size is likely to account for the lack of statistical significance for the advantage (indicating a moderate effect size, d = 0.45) of St John's wort over placebo.  


Field T, Hernandez-Reif M, Diego M, Schanberg S, Kuhn C. Cortisol decreases and serotonin and dopamine increase following massage therapy. Int J Neurosci. 2005 Oct;115(10):1397-413.
Touch Research Institutes, University of Miami School of Medicine, Miami, Florida 33101, USA.
In this article the positive effects of massage therapy on biochemistry are reviewed including decreased levels of cortisol and increased levels of serotonin and dopamine. The research reviewed includes studies on depression (including sex abuse and eating disorder studies), pain syndrome studies, research on auto-immune conditions (including asthma and chronic fatigue), immune studies (including HIV and breast cancer), and studies on the reduction of stress on the job, the stress of aging, and pregnancy stress. In studies in which cortisol was assayed either in saliva or in urine, significant decreases were noted in cortisol levels (averaging decreases 31%). In studies in which the activating neurotransmitters (serotonin and dopamine) were assayed in urine, an average increase of 28% was noted for serotonin and an average increase of 31% was noted for dopamine. These studies combined suggest the stress-alleviating effects (decreased cortisol) and the activating effects (increased serotonin and dopamine) of massage therapy on a variety of medical conditions and stressful experiences.  


Hsiao AF, Hays RD, Ryan GW, Coulter ID, Andersen RM, Hardy ML, Diehl DL, Hui KK, Wenger NS. A Self-Report Measure of Clinicians' Orientation toward Integrative Medicine. Health Serv Res. 2005 Oct;40(5 Pt 1):1553-69.
UCLA Department of Medicine, Division of GIM/HSR, 911 Broxton Plaza, Los Angeles, CA 90095-1736, USA.
OBJECTIVE: Patients in the U.S. often turn to complementary and alternative medicine (CAM) and may use it concurrently with conventional medicine to treat illness and promote wellness. However, clinicians vary in their openness to the merging of treatment paradigms. Because integration of CAM with conventional medicine can have important implications for health care, we developed a survey instrument to assess clinicians' orientation toward integrative medicine. STUDY SETTING: A convenience sample of 294 acupuncturists, chiropractors, primary care physicians, and physician acupuncturists in academic and community settings in California. DATA COLLECTION METHODS: We used a qualitative analysis of structured interviews to develop a conceptual model of integrative medicine at the provider level. Based on this conceptual model, we developed a 30-item survey (IM-30) to assess five domains of clinicians' orientation toward integrative medicine: openness, readiness to refer, learning from alternate paradigms, patient-centered care, and safety of integration. PRINCIPAL FINDINGS: Two hundred and two clinicians (69 percent response rate) returned the survey. The internal consistency reliability for the 30-item total scale and the five subscales ranged from 0.71 to 0.90. Item-scale correlations for the five subscales were higher for the hypothesized subscale than other subscales 75 percent or more of the time. Construct validity was supported by the association of the IM-30 total scale score (0-100 possible range, with a higher score indicative of greater orientation toward integrative medicine) with hypothesized constructs: physician acupuncturists scored higher than physicians (71 versus 50, p<.001), dual-trained practitioners scored higher than single-trained practitioners (71 versus 62, p<.001), and practitioners' self-perceived "integrativeness" was significantly correlated (r=0.60, p<.001) with the IM-30 total score. CONCLUSION: This study provides support for the reliability and validity of the IM-30 as a measure of clinicians' orientation toward integrative medicine. The IM-30 survey, which we estimate as requiring 5 minutes to complete, can be administered to both conventional and CAM clinicians.  


Jewell DV, Riddle DL. Interventions that increase or decrease the likelihood of a meaningful improvement in physical health in patients with sciatica. Phys Ther. 2005 Nov;85(11):1139-50.
Department of Physical Therapy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298-0224, USA.
BACKGROUND AND PURPOSE: The purpose of our study was to determine whether physical therapy interventions predicted meaningful short-term improvement in physical health for patients diagnosed with sciatica. SUBJECTS: We examined data from 1,804 patients (age: mean=52.1 years, SD=15.6 years; 65.7% female, 34.3% male) who had been diagnosed with sciatica and who had completed an episode of outpatient physical therapy. METHODS: Principal components factor analysis was used to define intervention categories from specific treatments applied during the plan of care. A nested-model logistic regression analysis identified intervention categories that predicted meaningful improvement in physical health. Meaningful improvement was defined as a change of 14 or more points on the Physical Component Scale-12 (PCS-12) summary score. RESULTS: Twenty-six percent (n=473) of patients had a meaningful improvement in physical health. Improvement was more likely in patients receiving joint mobility interventions (odds ratio [OR]=2.5, 95% confidence interval [CI]=1.5-4.4) or general exercise (OR=1.5, 95% CI=1.2-2.0). Patients who received spasm reduction interventions were less likely to improve (OR=0.77, 95% CI=0.60-0.98). DISCUSSION AND CONCLUSION: Physical therapists should emphasize the use of joint mobility interventions and exercise when treating patients with sciatica, whereas interventions for spasm reduction should be avoided.  


Joseph CN, Porta C, Casucci G, Casiraghi N, Maffeis M, Rossi M, Bernardi L.Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension. 2005 Oct;46(4):714-8.
Department of Internal Medicine, University of Pavia, IRCCS Ospedale S. Matteo, Pavia, Italy.
Sympathetic hyperactivity and parasympathetic withdrawal may cause and sustain hypertension. This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation. Slow breathing at 6 breaths/min increases baroreflex sensitivity and reduces sympathetic activity and chemoreflex activation, suggesting a potentially beneficial effect in hypertension. We tested whether slow breathing was capable of modifying blood pressure in hypertensive and control subjects and improving baroreflex sensitivity. Continuous noninvasive blood pressure, RR interval, respiration, and end-tidal CO2 (CO2-et) were monitored in 20 subjects with essential hypertension (56.4+/-1.9 years) and in 26 controls (52.3+/-1.4 years) in sitting position during spontaneous breathing and controlled breathing at slower (6/min) and faster (15/min) breathing rate. Baroreflex sensitivity was measured by autoregressive spectral analysis and "alpha angle" method. Slow breathing decreased systolic and diastolic pressures in hypertensive subjects (from 149.7+/-3.7 to 141.1+/-4 mm Hg, P<0.05; and from 82.7+/-3 to 77.8+/-3.7 mm Hg, P<0.01, respectively). Controlled breathing (15/min) decreased systolic (to 142.8+/-3.9 mm Hg; P<0.05) but not diastolic blood pressure and decreased RR interval (P<0.05) without altering the baroreflex. Similar findings were seen in controls for RR interval. Slow breathing increased baroreflex sensitivity in hypertensives (from 5.8+/-0.7 to 10.3+/-2.0 ms/mm Hg; P<0.01) and controls (from 10.9+/-1.0 to 16.0+/-1.5 ms/mm Hg; P<0.001) without inducing hyperventilation. During spontaneous breathing, hypertensive subjects showed lower CO2 and faster breathing rate, suggesting hyperventilation and reduced baroreflex sensitivity (P<0.001 versus controls). Slow breathing reduces blood pressure and enhances baroreflex sensitivity in hypertensive patients. These effects appear potentially beneficial in the management of hypertension.  


Kakigi R, Nakata H, Inui K, Hiroe N, Nagata O, Honda M, Tanaka S, Sadato N, Kawakami M. Intracerebral pain processing in a Yoga Master who claims not to feel pain during meditation. Eur J Pain. 2005 Oct;9(5):581-9.
Department of Integrative Physiology, National Institute for Physiological Sciences, Nishigo-Naka 38, Myodaiji, Okazaki 444-8585, Japan.
We recorded magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) following noxious laser stimulation in a Yoga Master who claims not to feel pain when meditating. As for background MEG activity, the power of alpha frequency bands peaking at around 10 Hz was much increased during meditation over occipital, parietal and temporal regions, when compared with the non-meditative state, which might mean the subject was very relaxed, though he did not fall asleep, during meditation. Primary pain-related cortical activities recorded from primary (SI) and secondary somatosensory cortices (SII) by MEG were very weak or absent during meditation. As for fMRI recording, there were remarkable changes in levels of activity in the thalamus, SII-insula (mainly the insula) and cingulate cortex between meditation and non-meditation. Activities in all three regions were increased during non-meditation, similar to results in normal subjects. In contrast, activities in all three regions were weaker during meditation, and the level was lower than the baseline in the thalamus. Recent neuroimaging and electrophysiological studies have clarified that the emotional aspect of pain perception mainly involves the insula and cingulate cortex. Though we cannot clearly explain this unusual condition in the Yoga Master, a change of multiple regions relating to pain perception could be responsible, since pain is a complex sensory and emotional experience.  


Kirkwood G, Rampes H, Tuffrey V, Richardson J, Pilkington K.Yoga for anxiety: a systematic review of the research evidence. Br J Sports Med. 2005 Dec;39(12):884-91; discussion 891
Research Council for Complementary Medicine, London, UK.
Between March and June 2004, a systematic review was carried out of the research evidence on the effectiveness of yoga for the treatment of anxiety and anxiety disorders. Eight studies were reviewed. They reported positive results, although there were many methodological inadequacies. Owing to the diversity of conditions treated and poor quality of most of the studies, it is not possible to say that yoga is effective in treating anxiety or anxiety disorders in general. However, there are encouraging results, particularly with obsessive compulsive disorder. Further well conducted research is necessary which may be most productive if focused on specific anxiety disorders.  


O-Yurvati AH, Carnes MS, Clearfield MB, Stoll ST, McConathy WJ. Hemodynamic effects of osteopathic manipulative treatment immediately after coronary artery bypass graft surgery. J Am Osteopath Assoc. 2005 Oct;105(10):475-81
Department of Surgery, Texas College of Osteopathic Medicine, University of North Texas Health Center, Fort Worth, TX 76107, USA.
CONTEXT: Coronary artery bypass graft (CABG) surgery is a common procedure for patients with coronary artery disease. The physiologic effects of postoperative osteopathic manipulative treatment (OMT) following CABG have not been documented previously. OBJECTIVE: To determine the effects of OMT on cardiac hemodynamics post-CABG surgery. DESIGN: Pilot prospective clinical study (N=29). SETTING AND PATIENTS: Treatment subjects (n=10) undergoing CABG surgery were recruited for postoperative OMT. The primary assessment compared, pre-OMT versus post-OMT, measurements of thoracic impedance, mixed venous oxygen saturation (SvO2), and cardiac index. Records of control subjects (n=19) who underwent CABG surgery--but who did not receive OMT--were assessed for SvO2 and cardiac index at 1 hour and 2 hours postsurgery. INTERVENTION: Immediately following CABG surgery (< or = 2 h), OMT was provided to subjects to alleviate anatomic dysfunction of the rib cage caused by median sternotomy and to improve respiratory function. This adjunctive treatment occurred while subjects were completely anesthetized. RESULTS: A post-OMT increase in thoracic impedance (P < or = .02) in OMT subjects demonstrated that central blood volume was reduced after OMT, suggesting an improved peripheral circulation. Mixed venous oxygen saturation also increased (P < or = .005) after OMT. These increases were accompanied by an improvement in cardiac index (P < or = .01). Comparisons of postoperative measurements in OMT subjects versus those in control subjects revealed statistically significant differences for SvO2 (P < or = .005) and cardiac index (P < or = .02) between the two groups. CONCLUSION: The observed changes in cardiac function and perfusion indicated that OMT had a beneficial effect on the recovery of patients after CABG surgery. The authors conclude that OMT has immediate, beneficial hemodynamic effects after CABG surgery when administered while the patient is sedated and pharmacologically paralyzed.  


Posfay-Barbe KM, Heininger U, Aebi C, Desgrandchamps D, Vaudaux B, Siegrist CA. How do physicians immunize their own children? Differences among pediatricians and nonpediatricians. Pediatrics. 2005 Nov;116(5):e623-33.
Centre for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.
CONTEXT: Immunization has an essential impact on public health worldwide. Numerous studies have shown the efficacy of different vaccines to protect individuals from various diseases. However, some parents choose not to vaccinate their children for reasons such as, among others, doubts regarding their usefulness, concerns over safety or efficacy, etc. Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children. OBJECTIVE: We sought to assess how physicians interested in vaccination issues immunized, or would immunize, their own children. DESIGN, SETTING, AND PARTICIPANTS: An 11-question, Web-based survey with a total of 102 discrete answers was sent to 2070 Swiss physicians in October 2004. All physicians were subscribers to a nonprofit, Web-based expert network (InfoVac, that distributes monthly newsletters and answers question within 2 days on immunization issues. The InfoVac network reaches > 95% of pediatricians in Switzerland but < 20% of general practitioners. All responses were anonymous, and no identifier could be used to trace the participants of the survey. Questions were divided into 2 parts: (1) physicians who were parents were asked which vaccines they gave to their own children and at what age, and (2) all physicians were asked which vaccines they would give to their own child and at what age if they had a newborn child in 2004. Vaccines available in Switzerland at the time of the survey were offered as possible replies, and recommended vaccines were considered as those noted in the Swiss federal immunization schedule issued yearly. One question compared their immunization practice between their own children and their patients. Sociodemographics, qualifying year, membership in different professional groups, and their type of practice were also requested. Statistics. Standard descriptive statistics were used for sociodemographic characteristics. Univariate statistical analyses were performed for each variable to determine its relationship to the dependent variable, being a pediatrician or nonpediatrician. Logistic-regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs), controlling for any statistically significant demographic variables that might function as confounders (gender, parenthood, workplace, year of diploma, and type of practice). For all statistical tests, differences were considered significant at P < .05. MAIN OUTCOME MEASURE: We performed a comparison of past and projected immunization rates in the children of pediatricians and nonpediatricians. RESULTS: One thousand seventeen valid questionnaires were received (response rate: 49.1%; pediatricians: 53.3%). Nine hundred fifteen physicians (90%) had > or = 1 child. All physicians reported immunizing children in their practice. Pediatricians were more likely to be women and to work in private practice than nonpediatricians but less likely to belong to a self-reported alternative medicine association. Among the nonpediatricians, 317 were general practitioners, 144 were internists, and 95 were other specialists. Ninety-two percent of pediatricians followed the official immunization recommendations for their own children. In contrast, after controlling for gender, workplace, type of practice, and year of diploma, nonpediatricians were more likely not to have immunized their children against measles, mumps, hepatitis B, or Haemophilus influenzae type b. They more frequently postponed diphtheria-tetanus-pertussis (DTP) (OR: 4.5; 95% CI: 2.0-10.19) and measles-mumps-rubella (MMR) vaccination. Although projected immunization rates were higher than effective rates, 10% of nonpediatricians would still not follow the official immunization recommendations in 2004. They would more frequently refrain from using combination vaccines and postpone DTP and MMR immunization to later in life. Several comparisons confirmed the weaker use of the more recently licensed vaccines by nonpediatricians. In addition to vaccines currently recommended in Switzerland, both groups of physicians added hepatitis A, influenza, and varicella vaccines to the vaccination schedule of their own children. Pediatricians were more likely to give pneumococcal (OR: 2.26; 95% CI: 1.004-4.68) and meningococcal C (OR: 2.26; 95% CI: 1.62-3.17) vaccines to their own children. In contrast, they were less likely to give tick-borne encephalitis virus vaccine (OR: 0.65; 95% CI: 0.44-0.95). CONCLUSIONS: Ninety-three percent of the surveyed physicians agree with the current official vaccination recommendations and would apply them to their own children. However, the observation that 5% of nonpediatricians would not use Haemophilus influenzae type b vaccine if they had a child born in 2004 is unexpected and concerning. In contrast, both groups gave additional vaccines than those recommended to their own children. Among physicians in Switzerland interested in immunization, a significant proportion of nonpediatricians decline or delay the immunization of their own children with the recommended MMR- or DTP-based combination vaccines, which indicates that clarification of misconceptions such as fear of "immune overload" has not yet reached important targets among health care providers who thus are unlikely to answer parental concerns adequately.  


Quandt SA, Chen H, Grzywacz JG, Bell RA, Lang W, Arcury TA. Use of complementary and alternative medicine by persons with arthritis: results of the National Health Interview Survey. Arthritis Rheum. 2005 Oct 15;53(5):748-55.
Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
OBJECTIVE: To compare the complementary and alternative medicine (CAM) used by adults ages 45 years and older with and without arthritis, and to investigate the prevalence and predictors of CAM use by persons who report being told by a doctor they had arthritis. METHODS: Data from the 2002 National Health Interview Survey with a supplemental section on CAM use were analyzed. Data on overall use and use by 4 CAM modalities were calculated by arthritis status. CAM use for treatment of any health condition, including arthritis, was calculated and compared by arthritis status. Logistic regression was used to identify predictors of CAM use among persons with arthritis. RESULTS: Overall use of CAM and use of 3 of 4 major CAM categories were higher for persons who reported doctor-diagnosed arthritis compared with those without arthritis. Biologically based therapies were the most frequently reported modalities. Although persons with arthritis were more likely than those without arthritis to report using CAM for treatment, most of their CAM use was for conditions other than arthritis. Joint pain and poor functional status were the most common predictors of CAM modalities among persons with arthritis. CONCLUSION: Health care providers of persons with arthritis should be aware that CAM use is common among their patients. A complete medication history is needed to obtain information on CAM use for all conditions.  


Sherman KJ, Cherkin DC, Erro J, Miglioretti DL, Deyo RA. Comparing yoga, exercise, and a self-care book for chronic low back pain: a randomized, controlled trial. Ann Intern Med. 2005 Dec 20;143(12):849-56.
Group Health Cooperative and University of Washington, Seattle, Washington, USA.

BACKGROUND: Chronic low back pain is a common problem that has only modestly effective treatment options. OBJECTIVE: To determine whether yoga is more effective than conventional therapeutic exercise or a self-care book for patients with chronic low back pain. DESIGN: Randomized, controlled trial. SETTING: A nonprofit, integrated health care system. PATIENTS: 101 adults with chronic low back pain. INTERVENTION: 12-week sessions of yoga or conventional therapeutic exercise classes or a self-care book. MEASUREMENTS: Primary outcomes were back-related functional status (modified 24-point Roland Disability Scale) and "bothersomeness" of pain (11-point numerical scale). The primary time point was 12 weeks. Clinically significant change was considered to be 2.5 points on the functional status scale and 1.5 points on the bothersomeness scale. Secondary outcomes were days of restricted activity, general health status, and medication use. RESULTS: After adjustment for baseline values, back-related function in the yoga group was superior to the book and exercise groups at 12 weeks (yoga vs. book: mean difference, -3.4 [95% CI, -5.1 to - 1.6] [P < 0.001]; yoga vs. exercise: mean difference, -1.8 [CI, -3.5 to - 0.1] [P = 0.034]). No significant differences in symptom bothersomeness were found between any 2 groups at 12 weeks; at 26 weeks, the yoga group was superior to the book group with respect to this measure (mean difference, -2.2 [CI, -3.2 to - 1.2]; P < 0.001). At 26 weeks, back-related function in the yoga group was superior to the book group (mean difference, -3.6 [CI, -5.4 to - 1.8]; P < 0.001). LIMITATIONS: Participants in this study were followed for only 26 weeks after randomization. Only 1 instructor delivered each intervention. CONCLUSIONS: Yoga was more effective than a self-care book for improving function and reducing chronic low back pain, and the benefits persisted for at least several months.  


Stefano GB, Esch T.Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review). Int J Mol Med. 2005 Oct;16(4):621-30.
Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA.
Relaxation techniques are part of the integrative medicine movement that is of growing importance for mainstream medicine. Complementary medical therapies have the potential to affect many physiological systems. Repeatedly studies show the benefits of the placebo response and relaxation techniques in the treatment of hypertension, cardiac arrhythmias, chronic pain, insomnia, anxiety and mild and moderate depression, premenstrual syndrome, and infertility. In itself, relaxation is characterized by a decreased metabolism, heart rate, blood pressure, and rate of breathing as well as an increase in skin temperature. Relaxation approaches, such as progressive muscle relaxation, autogenic training, meditation and biofeedback, are effective in lowering systolic and diastolic blood pressure in hypertensive patients by a significant margin. Given this association with changes in vascular tone, we have hypothesized that nitric oxide, a demonstrated vasodilator substance, contribute to physiological activity of relaxation approaches. We examined the scientific literature concerning the disorders noted earlier for their nitric oxide involvement in an attempt to provide a molecular rationale for the positive effects of relaxation approaches, which are physiological and cognitive process. We conclude that constitutive nitric oxide may crucially contribute to potentially beneficial outcomes and effects in diverse pathologies, exerting a global healing effect.  


Vinson JA, Al Kharrat H, Andreoli L. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine. 2005 Nov;12(10):760-5.
Department of Chemistry, University of Scranton, Scranton, PA, 18510 4626, USA.
There are no literature references describing the effect of consumption of Aloe vera liquid preparations on the absorption of water- or fat-soluble vitamins. There is a very large population worldwide which consume vitamins and many people also consume Aloe. Thus we report the effect of Aloe on the human absorption of vitamins C and E, the most popular vitamin supplements. The plasma bioavailability of vitamins C and E were determined in normal fasting subjects, with eight subjects for vitamin C and ten subjects for vitamin E. In a random crossover design, the subjects consumed either 500 mg of ascorbic acid or 420 mg of vitamin E acetate alone (control), or combined with 2 oz of two different Aloe preparations (a whole leaf extract, or an inner fillet gel). Blood was collected periodically up to 24 h after consumption. Plasma was analyzed for ascorbate and tocopherol by-HPLC with UV detection. There was no significant difference in the areas under the plasma ascorbate-time curves among the groups sincerely due to large differences within the groups. For comparative purposes the control area was 100%. The Aloe Gel area was 304%, and Aloe Whole Leaf 80%. Only Aloe Gel caused a significant increase in plasma ascorbate after 8 and 24 h. For vitamin E, the results for the relative areas were control 100%, Gel 369%, and Leaf (198%). Only the Aloes produced a significant increase in plasma tocopherol after 6 and 8 h. Both Aloes were significantly different from the control after 8 h. Aloe Gel was significantly different from the baseline after 24 h. The Aloes slowed down the absorption of both vitamins with maximum concentrations 2-4 h later than the control. There was no difference between the two types of Aloe. The results indicate that the Aloes improve the absorption of both vitamins C and E. The absorption is slower and the vitamins last longer in the plasma with the Aloes. Aloe is the only known supplement to increase the absorption of both of these vitamins and should be considered as a complement to them.  


Williams AL, Cotter A, Sabina A, Girard C, Goodman J, Katz DL. The role for vitamin B-6 as treatment for depression: a systematic review. Fam Pract. 2005 Oct;22(5):532-7.
Yale Prevention Research Center, Derby, CT 06418, USA.
BACKGROUND: Major depression is the leading cause of disability worldwide, and among the 10 most frequent indications for using alternative medicine therapies, especially dietary supplements. OBJECTIVE: To assess the evidence evaluating vitamin B-6 supplementation as treatment for depression. METHODS: Medline, Psychinfo, AMED, and Cochrane Controlled Trials Register were searched from database inception through September 2001. All randomized controlled trials, controlled clinical trials, intervention studies, case-control studies, reviews, and case reports examining the evidence behind vitamin B-6 in depression among humans were selected. No limits were placed for demographics or co-morbidities. Only English language papers were abstracted and assessed for trial quality. Two abstractors independently evaluated each study, then reconciled findings. As data were available, between group treatment effect size was noted or, as needed, calculated. When studies reported outcome effects using multiple measures, data were abstracted to permit the greatest possible comparisons among papers. RESULTS: Ten articles met inclusion criteria; three reviews, one case report, five RCTs, and one intervention study. There was no common outcome measure among all studies, eliminating opportunity for direct comparison of effect sizes. As an alternate means of comparison, effects were plotted as they related to the null hypothesis. CONCLUSION: Viewed as a whole, meaningful treatment effect of vitamin B-6 for depression in general was not apparent. However, examination of papers addressing depression in pre-menopausal women only, reveals a consistent message about the value of using vitamin B-6 supplementation. Further study of vitamin B-6 as independent and adjuvant therapy for hormone related depression in women is indicated.  


Yoo HJ, Ahn SH, Kim SB, Kim WK, Han OS. Efficacy of progressive muscle relaxation training and guided imagery in reducing chemotherapy side effects in patients with breast cancer and in improving their quality of life. Support Care Cancer. 2005 Oct;13(10):826-33.
Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Pungnap-dong Songpa-gu, 138-736 Seoul, South Korea.
GOALS: This study was designed to assess the effectiveness of progressive muscle relaxation training (PMRT) and guided imagery (GI) in reducing the anticipatory nausea and vomiting (ANV) and postchemotherapy nausea and vomiting (PNV) of patients with breast cancer and to measure their effects on the patients' quality of life (QoL). PATIENTS AND METHODS: Thirty chemotherapy-naive patients with breast cancer were randomized to the PMRT and GI group and 30 to the control group. Before each of six cycles of adjuvant chemotherapy, each patient was administered a self-report Multiple Affect Adjective Checklist (MAACL), and incidents of ANV and PNV for the first three postchemotherapy days were recorded. All patients were administered the Functional Assessment of Cancer Therapy-Breast (FACT-B) at baseline and after 3 and 6 months. RESULTS: We found that the PMRT and GI group was significantly less anxious, depressive, and hostile than the control group. We also found that the PMRT and GI group experienced significantly less ANV and PNV and that 6 months after CT, the QoL of the PMRT and GI group was higher than that of the control group. CONCLUSION: These results indicate that PMRT and GI were associated with both the improvements in ANV and PNV and in the QoL of patients with breast cancer.  


Yucel S, Akkaya E, Guntekin E, Kukul E, Akman S, Melikoglu M, Baykara M. Can alpha-blocker therapy be an alternative to biofeedback for dysfunctional voiding and urinary retention? A prospective study. J Urol. 2005 Oct;174(4 Pt 2):1612-5; discussion 1615.
Department of Urology, Akdeniz University School of Medicine, Antalya, Turkey.

PURPOSE: Traditional treatment of dysfunctional voiding in children with urinary retention involves retraining the pelvic floor muscles using biofeedback. Alpha-blockers are reported to also be effective in children with urinary retention and dysfunctional voiding. We compared the efficacy of biofeedback and alpha-blockers for dysfunctional voiding and urinary retention in terms of residual urine volume and urge incontinence episodes, mean flow rates and urinary tract infections. MATERIALS AND METHODS: A total of 28 patients with a mean age of 6.25 years (range 4 to 10) presented with symptoms of urinary incontinence, urgency and urinary tract infections without anatomic and neurogenic causes of urinary retention. All patients had increased post-void residual (PVR) urine volume (mean 59 ml, 32% of age expected capacity [AEC]). The biofeedback group consisted of 16 children (mean age 6.5 years) and the alpha-blocker group consisted of 12 children (mean age 5.9 years). Both groups were also on continued timed voiding, constipation treatment and anticholinergics, which had been used for at least the last 6 months. Biofeedback (median 10, range 6 to 16 sessions) and doxazosin (0.5 to 2 mg) were administered. At 3 and 6 months incontinence episodes, urinary tract infections, mean urinary flow rates, PVR and parental satisfaction grades (1 to
10) were reevaluated. Six refractory cases were started on alpha-blockers and biofeedback, and reevaluated after 1 month and 3 months. RESULTS: Pretreatment mean PVR was 54 ml (30% of AEC), and mean posttreatment PVR was 21 ml (12% of AEC) and 9 ml (5% of AEC) at 3 and 6 months in the biofeedback group (p <0.05). Pretreatment mean PVR was 64 ml (38% of AEC), and posttreatment mean PVR was 17 ml (12% of AEC) and 13 ml (8% of AEC) at 3 and 6 months in the alpha-blocker group (p <0.05). There was no statistical difference in posttreatment PVR between the 2 groups (p >0.05). High PVR persisted in 4 (25%) biofeedback cases and in 2 (16%) alpha-blocker cases. Complete improvement in urge incontinence episodes occurred in 10 (62.5%) and 7 (70%) children in the biofeedback and alpha-blocker groups, respectively. In therapy responsive children parental satisfaction was higher with alpha-blocker than with biofeedback (9.2 vs 7.9, p <0.05). Refractory high PVR decreased significantly after combination treatment with biofeedback and alpha-blocker in 5 of 6 children (mean 80 ml, 35% of AEC vs mean 15 ml, 7% of AEC). No drug related side effect was reported in the alpha-blocker group. CONCLUSIONS: Alpha-blocker therapy seems to be a viable alternative to biofeedback in dysfunctional voiding in children with urinary retention to improve bladder emptying. Combination treatment (biofeedback and alpha-blockers) can be used as additional therapy in refractory cases.  

14170 .     Abidi P, Zhou Y, Jiang JD, Liu J.  Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2170-6.

14171.    Agarwal A, Ranjan R, Dhiraaj S, Lakra A, Kumar M, Singh U.  Acupressure for prevention of pre-operative anxiety: a prospective, randomised, placebo controlled study. Anaesthesia. 2005 Oct;60(10):978-81.

14172.    Andresen V, Bach DR, Poellinger A, Tsrouya C, Stroh A, Foerschler A,eorgiewa P, Zimmer C,  onnikes H. Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome. Neurogastroenterol Motil. 2005 Dec;17(6):827-37.

14173.    Ansari NM, Houlihan L, Hussain B, Pieroni A.  Antioxidant activity of five vegetables traditionally consumed by South-Asian migrants in Bradford, Yorkshire, UK. Phytother Res. 2005 Oct;19(10):907-11.

14174.    Anthony JP, Fyfe L, Smith H.  Plant active components - a resource for antiparasitic agents? Trends Parasitol. 2005 Oct;21(10):462-8. Review.

14175.     Balunas MJ, Kinghorn AD.  Drug discovery from medicinal plants. Life Sci. 2005 Dec 22;78(5):431-41. Epub 2005 Sep 29. Review.

14176.    Barnfather KD, Cope GF, Chapple IL.  Effect of incorporating a 10 minute point of care test for salivary nicotine metabolites into a general practice based smoking cessation programme: randomised controlled trial. BMJ. 2005 Oct 29;331(7523):999.

14177.    Basso LA, da Silva LH, Fett-Neto AG, de Azevedo WF Jr, Moreira Ide S, PalmaMS, Calixto JB, Astolfi Filho S, dos Santos RR, Soares MB, Santos DS.   The use of biodiversity as source of  new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review. Mem Inst Oswaldo Cruz. 2005 Oct;100(6):475-506.

14178.    Bhattacharjee Y.  Neuroscience. Neuroscientists welcome Dalai Lama with mostly open arms. Science. 2005 No  18;310(5751):1104.  

14179.    Boero ME, Caviglia ML, Monteverdi R, Braida V, Fabello M, Zorzella LM.  Spirituality of health workers: a descriptive study. Int J Nurs Stud. 2005 Nov;42(8):915-21.

14180.    Canter PH, Coon JT, Ernst E.  Cost effectiveness of complementary treatments in the United Kingdom: systematic review. BMJ. 2005 Oct 15;331(7521):880-1. Review. 

14181.    Capehart KL.  The effects of contemporary and alternative medicine on healthcare and dentistry. Dent Today. 2005 Oct;24(10):14, 16.  

14182.    Chang WL, Wang HY, Shi LS, Lai JH, Lin HC. Immunosuppressive iridoids from the fruits of Gardenia jasminoides. J Nat Prod. 2005 Nov;68(11):1683-5.

14183.      Chen LW, Yung KL, Chan YS.  Reactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson's disease. Curr Drug Targets. 2005 Nov;6(7):821-33. Review.

14184.    Cohen MH, Kemper KJ, Stevens L, Hashimoto D, Gilmour J. Pediatric use of complementary therapies: ethical and policy choices. Pediatrics. 2005 Oct;116(4):e568-75.

14185.    Cooke M, Chaboyer W, Schluter P, Hiratos M.  The effect of music on preoperative anxiety in day surgery. J Adv Nurs. 2005 Oct;52(1):47-55.

14186.    Dantas F. Are the clinical effects of homoeopathy placebo effects? Lancet. 2005 Dec 17;366(9503):2083; author reply 2083-6. 

14187.    Dhiman RK, Chawla YK.  Herbal medicines for liver diseases. Dig Dis Sci. 2005 Oct;50(10):1807-12. Review. 

14188.    Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia. 2005 Nov;25(11):1031-41.

14189.    Dobson R.  Alternative therapies could save the NHS money, says report commissioned by Prince Charles. BMJ. 2005 Oct 8;331(7520):795. 

14190.    Dubois-Dalcq M, Ffrench-Constant C, Franklin RJ.  Enhancing central nervous system remyelination in multiple sclerosis. Neuron. 2005 Oct 6;48(1):9-12. Review.

14191.    Dunne N, Benda W, Kim L, Mittman P, Barrett R, Snider P, Pizzorno J. Naturopathic medicine: what can patients expect? J Fam Pract. 2005 Dec;54(12):1067-72. 

14192.    Dureau SJ.  The effect of gender on one-day-old infants' behavior and heart rate responses to music decibel level. J Music Ther. 2005 Fall;42(3):168-84.

14193.    Geisser ME, Wiggert EA, Haig AJ, Colwell MO. A randomized, controlled trial of manual therapy and specific adjuvant exercise for chronic low back pain. Clin J Pain. 2005 Nov-Dec;21(6):463-70.

14194.    Giargiari TD, Mahaffey AL, Craighead WE, Hutchison KE.  Appetitive responses to sexual stimuli are attenuated in individuals with low levels of sexual desire. Arch Sex Behav. 2005 Oct;34(5):547-56.

14195.    Graz B, Diallo D, Falquet J, Willcox M, Giani S.  Screening of traditional herbal medicine: first, do a retrospective study, with correlation between diverse treatments used and reported patient outcome. J Ethnopharmacol. 2005 Oct 3;101(1-3):338-9. 

14196.    Grzywacz JG, Lang W, Suerken C, Quandt SA, Bell RA, Arcury TA.  Age, race, and ethnicity in the use of complementary and alternative medicine for health self-management: evidence from the 2002 National Health Interview Survey. J Aging Health. 2005 Oct;17(5):547-72.

14197.    Hanna D, Bagshaw S.  National health and development youth policies: valuable exercises or bureaucratic niceties? Med J Aust. 2005 Oct 17;183(8):395-7. 

14198.    Hickman AG, Bell DM, Preston JC.  Acupressure and postoperative nausea and vomiting. AANA J. 2005 Oct;73(5):379-85. Review. 

14199.    Humphries C, Love T, Swinney D, Hickok G. Response of anterior temporal cortex to syntactic and prosodic manipulations during sentence processing. Hum Brain Mapp. 2005 Oct;26(2):128-38.

14200     Jamieson GA, Dwivedi P, Gruzelier JH.  Changes in mismatch negativity across pre-hypnosis, hypnosis and post-hypnosis conditions distinguish high from low hypnotic susceptibility groups. Brain Res Bull. 2005 Oct 30;67(4):298-303.

14201.      Jessie SW, Krishnakantha TP.  Inhibition of human platelet aggregation and membrane lipid peroxidation by food spice, saffron. Mol Cell Biochem. 2005 Oct;278(1-2):59-63.

14202.    Jones NL, Wine E.  Pediatric gastrointestinal diseases: are drugs the answer? Curr Opin Pharmacol. 2005 Dec;5(6):604-9.

14203.    Kang JX, Liu J, Wang J, He C, Li FP.  The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005 Nov;26(11):1934-9.

14204.    Kirpalani H, Vanderveen JA. Novel therapies need full outcome assessments. Indian Pediatr. 2005 Nov;42(11):1081-5.

14205.    Landis BN, Frasnelli J, Reden J, Lacroix JS, Hummel T.   Differences between orthonasal and retronasal olfactory functions in patients with loss of the sense of smell. Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):977-81.

14206.    Lauber C, Nordt C, Rossler W.  Recommendations of mental health professionals and the general population on how to treat mental disorders. Soc Psychiatry Psychiatr Epidemiol. 2005 Oct;40(10):835-43.

14207.    Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, McGarvey M, Quinn BT, Dusek JA, Benson H, Rauch SL, Moore CI, Fischl B.  Meditation experience is associated with increased cortical thickness. Neuroreport. 2005 Nov 28;16(17):1893-7.

14208.    Lopez LM, Grimes DA, Schulz KF. Nonhormonal drugs for contraception in men: a systematic review. Obstet Gynecol Surv. 2005 Nov;60(11):746-52. Review.

14209.    Martens S, Mithofer A.  Flavones and flavone synthases. Phytochemistry. 2005 Oct;66(20):2399-407.

14210.    Marwick C. Researchers investigate potential use of plant as a pain killer. BMJ. 2005 Nov 12;331(7525):1104. 

14211.      Mercier D, Knevitt A.  Using topical aromatherapy for the management of fungating wounds in a palliative care unit. J Wound Care. 2005 Nov;14(10):497-8, 500-1. 

14212.    Moisescu-Yiflach T, Pratt H.  Auditory event related potentials and source current density estimation in phonologic/auditory dyslexics. Clin Neurophysiol. 2005 Nov;116(11):2632-47.

14213.    Newall C, Stockley RA, Hill SL.  Exercise training and inspiratory muscle training in patients with bronchiectasis. Thorax. 2005 Nov;60(11):943-8.

14214.    Nitalikar MM, Gaikwad DD, Throat RM, Ambre SD. Tulsi: elixir of life. Antiseptic. 2005 May-Supplement; 102(5): 265-267.

14215.    Olney CM.  The effect of therapeutic back massage in hypertensive persons: a preliminary study. Biol Res Nurs. 2005 Oct;7(2):98-105.

14216.    Panossian A, Wagner H.   Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005 Oct;19(10):819-38. Review.

14217.    Patel SP, Hotston M, Kommu S, Persad RA.  The protective effects of green tea in prostate cancer. BJU Int. 2005 Dec;96(9):1212-4.  

14218.    Picerno P, Autore G, Marzocco S, Meloni M, Sanogo R, Aquino RP.   Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Nat Prod. 2005 Nov;68(11):1610-4.

14219.      Predy GN, Goel V, Lovlin R, Donner A, Stitt L, Basu TK. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ. 2005 Oct 25;173(9):1043-8.

14220.    Rapaka RS. Natureceuticals (natural products), herbal botanicals, psychoactives, hallucinogenics and related products. Life Sci. 2005 Dec 22;78(5):429-30.

14221.    Remmen R, Coenen S, Seuntjens R, Lesaffer C, Vermeirssen R. Honey for refractory diabetic foot ulcers. J Fam Pract. 2005 Oct;54(10):863. 

14222.    Rosti L, Gastaldi G.  Chronic salmonellosis and cinnamon. Pediatrics. 2005 Oct;116(4):1057. 

14223.    Rouleau JL. Treatment of congestive heart failure: present and future. Can J Cardiol. 2005 Oct;21(12):1084-8.

14224.    Rushton CH.  A framework for integrated pediatric palliative care: being with dying. J Pediatr Nurs. 2005 Oct;20(5):311-25. Review.

14225.    Sandberg M, Larsson B, Lindberg LG, Gerdle B.  Different patterns of blood flow response in the trapezius muscle following needle stimulation (acupuncture) between healthy subjects and patients with fibromyalgia and work-related trapezius myalgia. Eur J Pain. 2005 Oct;9(5):497-510.

14226.    Schmidt K, Rees C, Greenfield S, Wearn AM, Dennis I, Patil NG, Amri H,Boon H.   Multischool, international survey of medical students' attitudes toward "holism". Acad Med. 2005 Oct;80(10):955-63.

14227.    Seki K, Chisaka M, Eriguchi M, Yanagie H, Hisa T, Osada I, Sairenji T, Otsuka K, Halberg F.  An attempt to integrate Western and Chinese medicine: rationale for applying Chinese medicine as chronotherapy against cancer. Biomed Pharmacother. 2005 Oct;59 Suppl 1:S132-40.

14228.    Sengar M, Bhutani M, Aggarwal D, Kochupillai V. Cancer treatment: role of yoga, naturopathy and prayer. Health Administrator. 2005 Jul; 17(1): 151-157.

14229.      Seskevich J, Gabert H, Charles A, Cuffe MS.  Helping patients with heart failure manage stress. Nursing. 2005 Oct;35(10):23.  

14230.    Shekelle PG, Hardy M, Morton SC, Coulter I, Venuturupalli S, Favreau J,Hilton LK. Are Ayurvedic herbs for diabetes effective? J Fam Pract. 2005 Oct;54(10):876-86. Review.

14231.    Sidley P.  South African foundation is accused of "compromising" care of people with HIV and AIDS. BMJ. 2005 Oct 8;331(7520):800. 

14232.    Sloan RP, Ramakrishnan R. The MANTRA II study. Lancet. 2005 Nov 19;366(9499):1769-70; author reply 1770-1. 

14233.    Solanki K, Matnani M, Kale M, Joshi K, Bavdekar A, Bhave S, Pandit A. Transcutaneous absorption of topically massaged oil in neonates. Indian Pediatr. 2005 Oct;42(10):998-1005.

14234.    Teixeira MZ.  'Paradoxical strategy for treating chronic diseases': a therapeutic model used in homeopathy for more than two centuries. Homeopathy. 2005 Oct;94(4):265-6. 

14235.    Temple MD, Fagerlund K, Saewyc E.  A national survey of certified registered nurse anesthetists' knowledge, beliefs, and assessment of herbal supplements in the anesthesia setting. AANA J. 2005 Oct;73(5):368-77.

14236.    Thomsen M, Schmidt M, Vitetta L, Sali A.  Do herbs increase the risk of herb-drug interactions for patients with arthritis? Ann Rheum Dis. 2005 Oct;64(10):1527; author reply 1528. 

14237.    Vannier E, Avan P.  Classification of technical pitfalls in objective universal hearing screening by otoacoustic emissions, using an ARMA model of the stimulus waveform and bootstrap cross-validation. Med Eng Phys. 2005 Oct;27(8):669-77.

14238.    Weil A. Aging naturally. Time. 2005 Oct 17;166(16):60-6, 69-70. 

14239.    Wolf K, Mass R, Ingenbleek T, Kiefer F, Naber D, Wiedemann K.  The facial pattern of disgust, appetence, excited joy and relaxed joy: an improved facial EMG study. Scand J Psychol. 2005 Oct;46(5):403-9.

14240.    Wright AD, Lang-Unnasch N. Potential antimalarial lead structures from fungi of marine origin. Planta Med. 2005 Oct;71(10):964-6.

14241.    Wright S.   Drive thru spirituality. Nurs Stand . 2005 Oct 12-18;20(5):32-3. 

14242.    Yim R.  Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside. Transfusion. 2005 Oct;45(4 Suppl):144S-58S. Review.

14243.    Yucel S, Akkaya E, Guntekin E, Kukul E, Akman S, Melikoglu M, Baykara M.  Can alpha blocker therapy be an alternative to biofeedback for dysfunctional voiding and urinary retention? A prospective study. J Urol. 2005 Oct;174(4 Pt 2):1612-5; discussion 1615.

14244.    Zhang XW, Fan Y, Manyande A, Tian YK, Yin P.  Effects of music on target-controlled infusion of propofol requirements during combined spinal-epidural anaesthesia. Anaesthesia. 2005 Oct;60(10):990-4.

14245.    Zheng L, Faber K.  Review of the Chinese medical approach to the management of fibromyalgia. Curr Pain Headache Rep. 2005 Oct;9(5):307-12. Review.  


July 2006

Some selected abstracts: 


Digianni LM, Rue M, Emmons K, Garber JE. Complementary medicine use before and 1 year following genetic testing for BRCA1/2 mutations. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):70-5.
Dana-Farber Cancer Institute, 44 Binney Street, SM228, Boston, MA 02115, USA.

PURPOSE: We explored change in complementary and alternative medicine (CAM) use by unaffected women and cancer survivors from enrollment into a randomized BRCA1/2 testing program to CAM use 1 year following results disclosure.METHODS: A cohort of 243 high-risk women completed questionnaires at enrollment into a BRCA1/2 randomized trial and 1 year post results disclosure. Uses of several CAMs for cancer prevention were explored, including ingestible, behavioral, and physical modalities. Assessment of the change in CAM use from baseline to 1 year follow-up was conducted using a repeated self-administered questionnaire. Correlates of the number of CAMs used at 1 year were explored using multivariable linear regression models.RESULTS: Among the subset of women who changed their CAM behavior from enrollment to 1 year following BRCA1/2 results disclosure, there was a significantly higher proportion who changed from no CAM use to CAM use among the overall cohort (P=0.01), among women without cancer at enrollment (P=0.003), among women found to be BRCA1/2 carriers (P=0.03), and among women randomized to the genetic counseling intervention arm of the study (P=0.009). Number of CAMs used at 1 year was positively associated with number of CAMs used at baseline, sunscreen use, and BRCA1/2 mutation status.CONCLUSION: High-risk women who have received BRCA1/2 counseling and testing frequently adopt new CAM use in the first year after learning their genetic status. Mutation carriers frequently initiate CAM use after learning their genetic status as part of their cancer preventive regimen. Further studies are warranted to determine the efficacy of CAM-related strategies for cancer prevention. (Cancer Epidemiol Biomarkers Prev 2006;15(1):70-5).


Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006 Jan-Feb;12(1):50-4.
Next Pharmaceuticals, Inc, Irvine, CA, USA.

OBJECTIVE: To determine the efficacy of a dietary supplement ingredient containing proprietary extracts of Magnolia officinalis and Phellodendron amurense in helping overweight, otherwise healthy, premenopausal female adults, who typically eat more in stressful situations manage their body weight. DESIGN: Randomized, double-blind, placebo-controlled clinical study. Setting Miami Research Associates, a clinical research organization consisting of 32 board-certified physicians, Miami, Fla. SUBJECTS: Healthy, overweight (BMI 25 to 34.9), premenopausal female adults, between the ages of 20 and 50 years, who typically eat more in response to stressful situations and scored above the national mean for women on self-reported anxiety. INTERVENTIONS: Two-hundred-fifty-mg capsules or identical placebo capsules 3 times a day for 6 weeks. MAIN OUTCOME MEASURES: Salivary cortisol levels, weight change, psychological measures of stress and anxiety. RESULTS: Twenty-eight subjects completed the study. Extracts of M officinalis and P amurense were well tolerated. There was a significant weight gain during the study for the placebo group (P < ,01), but no significant weight gain for the group receiving extracts of M officinalis and P amurense (P < .89). Paired t-tests comparing baseline to post-treatment weight showed an average gain of 1.5 kg in the placebo group and no change in the treatment group (P = .89). When groups were divided into gainers (ie, participants who gained at least 1 kg or more) and maintainers or losers, 75% of the control group were gainers versus 37% of the treatment group (P < .04). There was a nonsignificant trend for lowered average cortisol in the treatment group at the end of the study (group X time interaction, F = 1.1, P < .15). This difference was due to a treatment effect on evening cortisol. There was a marginally significant group X time interaction (P = .06), showing the treatment group tended to have lower levels of cortisol in the evening, whereas the control group tended to have higher levels of cortisol in the evening. Bedtime cortisol levels decreased in the treatment group and increased in the placebo group. Participants in both the treatment and placebo groups had improved scores on a number of psychological measures during the study. There was a correlation between perceived stress and weight change. CONCLUSION: The results of this pilot clinical study indicate that obese subjects who eat in response to stress may benefit from taking a dietary supplement ingredient containing proprietary extracts of M officinalis and P amurense. The mechanism of action appears to be through reduction of cortisol levels and possibly perceived stress, thereby helping participants maintain body weight. The sample size was small, however, and there was higher attrition in the control group than in the treatment group.


Hsieh LL, Kuo CH, Lee LH, Yen AM, Chien KL, Chen TH. Treatment of low back pain by acupressure and physical therapy: randomized controlled trial. BMJ. 2006 Mar 25;332(7543):696-700.
Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
OBJECTIVE: To evaluate the effectiveness of acupressure in terms of disability, pain scores, and functional status. DESIGN: Randomised controlled trial. SETTING: Orthopaedic clinic in Kaohsiung, Taiwan. PARTICIPANTS: 129 patients with chronic low back pain. INTERVENTION: Acupressure or physical therapy for one month. MAIN OUTCOME MEASURES: Self administered Chinese versions of standard outcome measures for low back pain (primary outcome: Roland and Morris disability questionnaire) at baseline, after treatment, and at six month follow-up. RESULTS: The mean total Roland and Morris disability questionnaire score after treatment was significantly lower in the acupressure group than in the physical therapy group regardless of the difference in absolute score (- 3.8, 95% confidence interval - 5.7 to - 1.9) or mean change from the baseline (- 4.64, - 6.39 to - 2.89). Acupressure conferred an 89% (95% confidence interval 61% to 97%) reduction in significant disability compared with physical therapy. The improvement in disability score in the acupressure group compared with the physical group remained at six month follow-up. Statistically significant differences also occurred between the two groups for all six domains of the core outcome, pain visual scale, and modified Oswestry disability questionnaire after treatment and at six month follow-up. CONCLUSIONS: Acupressure was effective in reducing low back pain in terms of disability, pain scores, and functional status. The benefit was sustained for six months.


Kou V, Nassisi D. Unstable angina and non-ST-segment myocardial infarction: an evidence-based approach to management. Mt Sinai J Med. 2006 Jan;73(1):449-68. Review. Department of Emergency Medicine, Box 1149, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029-6574, USA.
Unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) represent two common, closely related acute coronary syndromes with potentially high morbidity and mortality. Integration of information from the history, physical exam, electrocardiogram, and cardiac biomarkers is used to formulate both the diagnosis of UA/NSTEMI and the overall assessment of patient prognosis and risk. Early diagnosis and risk stratification of patients with UA/NSTEMI enable the physician to initiate timely, appropriate treatment. (There is strong clinical evidence supporting the tailoring of specific therapies to the risk profile of the patient.) In recent years, powerful new medical and invasive therapies have been developed. Pharmaceutical agents for UA/NSTEMI may be broadly grouped into one of three categories: anti-ischemic, anti-platelet, and anti-thrombotic agents. Standard therapy for UA/NSTEMI has commonly included oxygen, aspirin, nitrates, morphine, beta-blockers and heparin. Potent new anti-platelet agents, including inhibitors of platelet adenosine diphosphate and glycoprotein IIb/IIIa receptors, play important, expanding roles in the management of these syndromes. Low-molecular-weight heparins have been shown to be an effective alternative to unfractionated heparin in their treatment. Major advances in invasive techniques and devices over the last decade include revascularization with percutaneous coronary intervention and drug-eluting intracoronary stents. Strong interest exists in studying the potential benefits and risks associated with an early invasive therapeutic strategy rather than an aggressive medical regimen for patients with UA/NSTEMI. As new treatments are rapidly added to our growing arsenal of management options, clinicians are constantly challenged with incorporating complex new information and guidelines into their practices in a timely fashion. To assist clinicians with this challenge, this article will review the evidence to support the use of current therapeutic options for UA/NSTEMI, with an emphasis on summarizing the most recent clinical guidelines jointly published by the American College of Cardiology and the American Heart Association.


Puhan MA, Suarez A, Lo Cascio C, Zahn A, Heitz M, Braendli O. Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial. BMJ. 2006 Feb 4;332(7536):266-70.
Horten Centre, University of Zurich, 8091 Zurich, Switzerland.

OBJECTIVE: To assess the effects of didgeridoo playing on daytime sleepiness and other outcomes related to sleep by reducing collapsibility of the upper airways in patients with moderate obstructive sleep apnoea syndrome and snoring. DESIGN: Randomised controlled trial. SETTING: Private practice of a didgeridoo instructor and a single centre for sleep medicine. PARTICIPANTS: 25 patients aged > 18 years with an apnoea-hypopnoea index between 15 and 30 and who complained about snoring. INTERVENTIONS: Didgeridoo lessons and daily practice at home with standardised instruments for four months. Participants in the control group remained on the waiting list for lessons. MAIN OUTCOME MEASURE: Daytime sleepiness (Epworth scale from 0 (no daytime sleepiness) to 24), sleep quality (Pittsburgh quality of sleep index from 0 (excellent sleep quality) to 21), partner rating of sleep disturbance (visual analogue scale from 0 (not disturbed) to 10), apnoea-hypopnoea index, and health related quality of life (SF-36). RESULTS: Participants in the didgeridoo group practised an average of 5.9 days a week (SD 0.86) for 25.3 minutes (SD 3.4). Compared with the control group in the didgeridoo group daytime sleepiness (difference -3.0, 95% confidence interval -5.7 to -0.3, P = 0.03) and apnoea-hypopnoea index (difference -6.2, -12.3 to -0.1, P = 0.05) improved significantly and partners reported less sleep disturbance (difference -2.8, -4.7 to -0.9, P < 0.01). There was no effect on the quality of sleep (difference -0.7, -2.1 to 0.6, P = 0.27). The combined analysis of sleep related outcomes showed a moderate to large effect of didgeridoo playing (difference between summary z scores -0.78 SD units, -1.27 to -0.28, P < 0.01). Changes in health related quality of life did not differ between groups. CONCLUSION: Regular didgeridoo playing is an effective treatment alternative well accepted by patients with moderate obstructive sleep apnoea syndrome. Trial registration ISRCTN: 31571714.

14562. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol. 2006 Jan;69(1):195-206.

14563. Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006 Mar;136(3 Suppl):716S-725S. Review.

14564. Anand Kumar BH, Sachidanand YN. Herbal formulation in the treatment of different types of dermatitis. Indian Practitioner. 2001 Aug; 54(8): 571-5.

14565. Arakawa K, Saruta T, Abe K, Iimura O, Ishii M, Ogihara T, Hiwada K, Fukiyama K, Fujishima M, Mizuno Y, Kikuchi T, Takaori S. Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: a double-blind, placebo-controlled study. Phytomedicine. 2006 Jan;13(1-2):1-10.

14566. Arcury TA, Bell RA, Snively BM, Smith SL, Skelly AH, Wetmore LK, Quandt SA. Complementary and alternative medicine use as health self-management: rural older adults with diabetes. J Gerontol B Psychol Sci Soc Sci. 2006 Mar;61(2):S62-70.

14567. Bajaj P, Kelkar A, Kumar D. Acupuncture therapy for pain of different origin. Indian Practitioner. 1996 Aug; 49(8): 641-3.

14568. Barker R, Kober A, Hoerauf K, Latzke D, Adel S, Kain ZN, Wang SM. Out-of-hospital auricular acupressure in elder patients with hip fracture: a randomized double-blinded trial. Acad Emerg Med. 2006 Jan;13(1):19-23.

14569. Bensoussan M, Jovenin N, Garcia B, Vandromme L, Jolly D, Bouche O, Thiefin G, Cadiot G. Complementary and alternative medicine use by patients with inflammatory bowel disease: results from a postal survey. Gastroenterol Clin Biol. 2006 Jan;30(1):14-23.

14570. Brazier A, Mulkins A, Verhoef M. Evaluating a yogic breathing and meditation intervention for individuals living with HIV/AIDS. Am J Health Promot. 2006 Jan-Feb;20(3):192-5.

14571. Breuer GS, Orbach H, Elkayam O, Berkun Y, Paran D, Mates M, Nesher G. Use of complementary and alternative medicine among patients attending rheumatology clinics in Israel. Isr Med Assoc J. 2006 Mar;8(3):184-7.

14572. Cabyoglu MT, Ergene N, Tan U. The mechanism of acupuncture and clinical applications. Int J Neurosci. 2006 Feb;116(2):115-25. Review.

14573. Cabyoglu MT, Ergene N, Tan U. The treatment of obesity by acupuncture. Int J Neurosci. 2006 Feb;116(2):165-75. Review.

14574 Carr RR, Nahata MC. Complementary and alternative medicine for upper-respiratory-tract infection in children. Am J Health Syst Pharm. 2006 Jan 1;63(1):33-9. Review.

14575. Chakrabarti I, Pal G. The concept of individualisation and its application in homoeopathy. Bull Natn Inst Homoeopathy 2004, 7(1), 29-36.

14576. Chavez ML, Jordan MA, Chavez PI. Evidence-based drug--herbal interactions. Life Sci. 2006 Mar 27;78(18):2146-57. Review.

14577. Clark H, Rome K, Plant M, O'Hare K, Gray J. A critical review of foot orthoses in the rheumatoid arthritic foot. Rheumatology (Oxford). 2006 Feb;45(2):139-45. Review.

14578. Corelli RL, Hudmon KS. Pharmacologic interventions for smoking cessation. Crit Care Nurs Clin North Am. 2006 Mar;18(1):39-51, xii. Review.

14579. Das SK; Mohanty RK; Nanda DK; Misra S. A clinical trial of epidural steroid injection (Depo-Medrol) in the treatment of chronic low back pain. Journal of Anaesthesiology. 2004 Apr; 20(2): 157-160.

14580. Dew K. Documentary analysis in CAM research: Part 2. Complement Ther Med. 2006 Mar;14(1):77-80.

14581. Dhasmana KM; Rating W; Bhatia M. Pharmacotherapeutic approach to the management of acute and chronic pain. Indian Journal of Anaesthesia. 1995; 43(5): 327-43.

14582. Dolce Filho R. Homeopathic approach in the treatment of patients with mental disability. Homeopathy. 2006 Jan;95(1):31-44. Review.

14583. Efferth T. Pharmacognosy and molecular pharmacology of small molecules of natural origin for cancer therapy and chemoprevention. Curr Drug Targets. 2006 Mar;7(3):237-8.

14584. Ernst E. Complementary and alternative medicine for children: a good or a bad thing? Arch Dis Child. 2006 Feb;91(2):96-7. Review.

14585. Fisher P. Changing reality. Homeopathy. 2006 Jan;95(1):1-2.

14586. Frost H, Stewart-Brown S. Acupressure for low back pain. BMJ. 2006 Mar 25;332(7543):680-1.

14587. Gilbert R. Fluid intake and bladder and bowel function. Nurs Times. 2006 Mar 21-27;102(12):55-6, 59. Review.

14588. Gopal MG, Farahana B. Effectiveness of herbal medications in the treatment of acne vulgaris - a pilot study. Indian Practitioner. 2001 Oct; 54(10): 723-7.

14589. Griffin S, Bojke L, Main C, Palmer S. Incorporating direct and indirect evidence using bayesian methods: an applied case study in ovarian cancer. Value Health. 2006 Mar-Apr;9(2):123-31.

14590. Hahn T, Wall D, Camitta B, Davies S, Dillon H, Gaynon P, Larson RA, Parsons S, Seidenfeld J, Weisdorf D, McCarthy PL Jr. The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute lymphoblastic leukemia in adults: an evidence-based review. Biol Blood Marrow Transplant. 2006 Jan;12(1):1-30. Review.

14591. Hallert E, Husberg M, Skogh T. Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology (Oxford). 2006 Mar;45(3):325-31.

14592. Hazra J; Srikanth N; Chopra KK. Holistic approach to the management of diabetes mellitus with classical and folk plant drugs. Health Administrator. 1996 Jul & 1997 Dec; 7 & 8(1 & 2): 131-7.

14593. Heller J, Gabbay JS, Ghadjar K, Jourabchi M, O'Hara C, Heller M, Bradley JP. Top-10 list of herbal and supplemental medicines used by cosmetic patients: what the plastic surgeon needs to know. Plast Reconstr Surg. 2006 Feb;117(2):436-45; discussion 446-7.

14594. Huntley A. A review of the evidence for efficacy of complementary and alternative medicines in MS. Int MS J. 2006 Jan;13(1):5-12, 4. Review.

14595. Johnson BR, Schwartz A, Goldberg J, Koerber A. A chairside aid for shared decision making in dentistry: a randomized controlled trial. J Dent Educ. 2006 Feb;70(2):133-41.

14596. Kala CP, Farooquee NA, Majila BS. Indigenousknowledge and medicinal plants used by vaidyas in Uttarancha! l, India. Nat Prod Radiance 2005, 4(3), 195-204.

14597. Kaptchuk TJ, Stason WB, Davis RB, Legedza AR, Schnyer RN, Kerr CE, Stone DA, Nam BH, Kirsch I, Goldman RH. Sham device v inert pill: randomised controlled trial of two placebo treatments. BMJ. 2006 Feb 18;332(7538):391-7.

14598. Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, Kaptchuk TJ. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci. 2006 Jan 11;26(2):381-8.

14599. Langmead L, Rampton DS. Review article: complementary and alternative therapies for inflammatory bowel disease. Aliment Pharmacol Ther. 2006 Feb 1;23(3):341-9. Review.

14600. Lee TL. Role of acupuncture in chronic pain. Journal of Anaesthesiology. 1999 Oct.; 15(4): 536-7.

14601. Leung PH, Zhang L, Zuo Z, Lin G. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6.

14602. Linde K, Barrett B, Wolkart K, Bauer R, Melchart D. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD000530. Review.

14603. Linde K, Weidenhammer W, Streng A, Hoppe A, Melchart D. Acupuncture for osteoarthritic pain: an observational study in routine care. Rheumatology (Oxford). 2006 Feb;45(2):222-7.

14604. Lohse B, Stotts JL, Priebe JR. Survey of herbal use by Kansas and Wisconsin WIC participants reveals moderate, appropriate use and identifies herbal education needs. J Am Diet Assoc. 2006 Feb;106(2):227-37.

14605. MacLennan AH, Myers SP, Taylor AW. The continuing use of complementary and alternative medicine in South Australia: costs and beliefs in 2004. Med J Aust. 2006 Jan 2;184(1):27-31.

14606. Maillard M, Burnier M. Comparative cardiovascular safety of traditional nonsteroidal anti-inflammatory drugs. Expert Opin Drug Saf. 2006 Jan;5(1):83-94. Review.

14607. Manheimer E, Ezzo J, Hadhazy V, Berman B. Published reports of acupuncture trials showed important limitations. J Clin Epidemiol. 2006 Feb;59(2):107-13. Review.

14608. Manjunath NK, Telles S. Influence of yoga and ayurveda on self-rated sleep in a geriatricpopulation. Indian J med Res 2005, 121(5), 683-90.

14609. McCann LJ, Newell SJ. Survey of paediatric complementary and alternative medicine use in health and chronic illness. Arch Dis Child. 2006 Feb;91(2):173-4.

14610. Michener JL, Ostbye T, Kaprielian VS, Krause KM, Yarnall KS, Yaggy SD, Gradison M. Alternative models for academic family practices. BMC Health Serv Res. 2006 Mar 20;6:38.

14611. Moebus S, Lehmann N, Bodeker W, Jockel KH. An analysis of sickness absence in chronically ill patients receiving complementary and alternative medicine: a longterm prospective intermittent study. BMC Public Health. 2006 Feb 12;6:28.

14612. Molassiotis A, Panteli V, Patiraki E, Ozden G, Platin N, Madsen E, Browall M, Fernandez-Ortega P, Pud D, Margulies A. Complementary and alternative medicine use in lung cancer patients in eight European countries. Complement Ther Clin Pract. 2006 Feb;12(1):34-9.

14613. Morton J, Williams Y, Philpott M. New Zealand's Christchurch Hospital at night: an audit of medical activity from 2230 to 0800 hours. N Z Med J. 2006 Mar 31;119(1231):U1916.

14614. Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol. 2006 Jan 3;103(1):25-35. Review.

14615. Murray JL. Identifying effective alternative therapies for common conditions. Am Fam Physician. 2006 Feb 1;73(3):396, 398.

14616. Nachulewicz P, Kaminski A, Kalicinski P, Kmiec T, Szaplyko W, Teisseyre J, Kowalski A. Analysis of neurological complications in children transplanted due to fulminant liver failure. Transplant Proc. 2006 Jan-Feb;38(1):253-4.

14617. Narinder Kaur, Gupta AK. Signal transduction pathways under abiotic stress in plants. Curr Sci 2005, 88(11), 1771-80.

14618. Nelson SK, Bose SK, Grunwald GK, Myhill P, McCord JM. The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. Free Radic Biol Med. 2006 Jan 15;40(2):341-7.

14619. O'Dell KK, McGee S. Acupuncture for urinary urgency in women over 50: what is the evidence? Urol Nurs. 2006 Feb;26(1):23-30. Review.

14620. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003230. Review.

14621. Poulos AE, Balandin S, Llewellyn G, Dew AH. Women with cerebral palsy and breast cancer screening by mammography. Arch Phys Med Rehabil. 2006 Feb;87(2):304-7. Review.

14622. Quattrin R, Zanini A, Buchini S, Turello D, Annunziata MA, Vidotti C, Colombatti A, Brusaferro S. Use of reflexology foot massage to reduce anxiety in hospitalized cancer patients in chemotherapy treatment: methodology and outcomes. J Nurs Manag. 2006 Mar;14(2):96-105.

14623. Raju YS, Naval Chandra. Efficacy and safety of Abacavir /Lamivudine / Zidovudine in patients with proven AIDS - report on 18 Indian patients. Indian med Gaz 2005, 139(6), 266-8.

14624. Ranjan; Mishra DN. Evaluation of the efficacy of V-Gel in vaginitis and cervicitis. Indian Practitioner. 2001 Sep; 54(9): 645-9.

14625. Rivlin RS. Is garlic alternative medicine? J Nutr. 2006 Mar;136(3 Suppl):713S-715S.

14626. Rorsman Ia, Johansson B. Can electroacupuncture or transcutaneous nerve stimulation influence cognitive and emotional outcome after stroke? J Rehabil Med. 2006 Jan;38(1):13-9.

14627. Sandhya T, Lathika KM, Pandey BN, Mishra KP. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett. 2006 Jan 18;231(2):206-14.

14628. Sayal SK; Banerjee S; Das AL; Gupta CM; Doiphade VV; Gogte RB; Uppal SS. Role of ayurvedic drugs in treatment of HIV infection [Letter]. Medical Journal Armed Forces India. 1998 Oct; 54(4): 374.

14629. Shapiro J, Rucker L, Beck J. Training the clinical eye and mind: using the arts to develop medical students' observational and pattern recognition skills. Med Educ. 2006 Mar;40(3):263-8.

14630. Sherman KJ, Cherkin DC, Deyo RA, Erro JH, Hrbek A, Davis RB, Eisenberg DM. The diagnosis and treatment of chronic back pain by acupuncturists, chiropractors, and massage therapists. Clin J Pain. 2006 Mar-Apr;22(3):227-34.

14631. Shin KR, Kwak SA, Lee JB, Yi HR. The effectiveness of hand acupuncture and moxibustion in decreasing pain and "coldness" in Korea women who have had hysterectomy: a pilot study. Appl Nurs Res. 2006 Feb;19(1):22-30.

14632. Smith J, Hurdle MF. Office-based ultrasound-guided intra-articular hip injection: technique for physiatric practice. Arch Phys Med Rehabil. 2006 Feb;87(2):296-8.

14633. Song S. Mind over medicine. Time. 2006 Mar 27;167(13):47.

14634. Stjernberg L, Berglund J, Halling A. Age and gender effect on the use of herbal medicine products and food supplements among the elderly. Scand J Prim Health Care. 2006 Mar;24(1):50-5.

14635. Stuifbergen AK. Building health promotion interventions for persons with chronic disabling conditions. Fam Community Health. 2006 Jan-Mar;29(1 Suppl):28S-34S. Review.

14636. Styczynski J, Wysocki M. Alternative medicine remedies might stimulate viability of leukemic cells. Pediatr Blood Cancer. 2006 Jan;46(1):94-8.

14637. Sucher NJ. Insights from molecular investigations of traditional Chinese herbal stroke medicines: implications for neuroprotective epilepsy therapy. Epilepsy Behav. 2006 Mar;8(2):350-62. Review.

14638. Tian X, Krishnan S. Efficacy of auricular acupressure as an adjuvant therapy in substance abuse treatment: a pilot study. Altern Ther Health Med. 2006 Jan-Feb;12(1):66-9.

14639. Tiwari AK. Wisdom of ayurveda in perceiving diabetes: enigma of therapeuticrecognition. curr Sci 2005, 88(7), 1043-51.

14640. Travis SP, Stange EF, Lemann M, Oresland T, Chowers Y, Forbes A, D'Haens G, Kitis G, Cortot A, Prantera C, Marteau P, Colombel JF, Gionchetti P, Bouhnik Y, Tiret E, Kroesen J, Starlinger M, Mortensen NJ; European Crohn's and Colitis Organisation. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut. 2006 Mar;55 Suppl 1:i16-35.

14641. van den Berg M, Visser A, Schoolmeesters A, Edelman P, van den Borne B. Evaluation of haptotherapy for patients with cancer treated with chemotherapy at a day clinic. Patient Educ Couns. 2006 Mar;60(3):336-43.

14642. Vickers AJ, Kuo J, Cassileth BR. Unconventional anticancer agents: a systematic review of clinical trials. J Clin Oncol. 2006 Jan 1;24(1):136-40. Review.

14643. Wadsworth LT. Acupuncture in sports medicine. Curr Sports Med Rep. 2006 Feb;5(1):1-3. Review.

14644. Wang G, Wang L, Xiong ZY, Mao B, Li TQ. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci Monit. 2006 Jan;12(1):SR1-7.

14645. Weber DO. Mainstreaming of alternative medicine. Health Administrator. 1996 Jul & 1997 Dec; 7 & 8(1 & 2): 26-40.

14646. White AR, Rampes H, Campbell JL. Acupuncture and related interventions for smoking cessation. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD000009. Review.

14647. Widdicombe J, Singh V. Physiological and pathophysiological down-regulation of cough. Respir Physiol Neurobiol. 2006 Feb 28;150(2-3):105-17. Review.

14648. Williams S, Dale J. The effectiveness of treatment for depression/depressive symptoms in adults with cancer: a systematic review. Br J Cancer. 2006 Feb 13;94(3): 372-90.

14649. Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, Hseu TH, Kuo CT, Hseu YC. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett. 2006 Jan 18;231(2):215-27.

14650. Yip YB, Tse SH. An experimental study on the effectiveness of acupressure with aromatic lanender essential oil for sub-acute, non-specific neck pain in Hong Kong.Complement Ther Clin Pract. 2006 Feb;12(1):18-26.


October 2006


Some selected abstract:


Bai N, Lai CS, He K, Zhou Z, Zhang L, Quan Z, Zhu N, Zheng QY, Pan MH, Ho CT.  Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J Nat Prod. 2006 Apr;69(4):531-5.
Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.


Chang TT, Huang CC, Hsu CH. Clinical evaluation of the Chinese herbal medicine formula STA-1 in the treatment of allergic asthma. Phytother Res. 2006 May;20(5):342-7.
Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
Although some formulae of traditional Chinese medicines (TCM) have been used for antiasthma treatment, few of them have had sufficient discussion on their efficacy, safety and mechanisms. In this study, the availability of the TCM formula STA-1 for the treatment of allergic asthma was investigated by conducting a double-blind, placebo-controlled and randomized trial. One hundred and twenty patients between the ages of 5 to 20 years with mild-to-moderate asthma were included. These patients were treated with either STA-1 or placebo in a dose of 80 g/kg/day and were administered twice daily for 6 months. The main outcome measures were a daily diary record of symptoms, supplementary bronchodilator and glucocorticoid treatment, changes of pulmonary function (forced expiratory volume in 1 s), changes of total and Dermatophagoides pteronyssinus (DP)-specific IgE and side effects. The results showed a statistically significant reduction of symptom scores, systemic steroid dose, total IgE and specific IgE in the STA-1 group. Furthermore, STA-1 also improved the pulmonary lung function FEV(1) compared with the placebo group and only minimal side effects were shown. These results suggested that STA-1 is available for the treatment of mild-to-moderate chronic asthma. Copyright 2006 John Wiley & Sons, Ltd.


Hargrave DR, Hargrave UA, Bouffet E. Quality of health information on the Internet in pediatric neuro-oncology. Neuro-oncol. 2006 Apr;8(2):175-82.
Marsden Hospital, Sutton, Surrey SM2 5PT, UK.
The Internet is now the single largest source of health information and is used by many patients and their families who are affected by childhood brain tumors. To assess the quality of pediatric neuro-oncology information on the Internet, we used search engines to look for information on five common tumor types (brain stem glioma, craniopharyngioma, ependymoma, low-grade glioma, and medulloblastoma). The Web sites were evaluated for content quality by using the validated DISCERN rating instrument. Breadth of content and its accuracy were also scored by a checklist tool. Readability statistics were computed on the highest-rated sites. Of 114 evaluated Web sites, the sources were as follows: institutiona
l, 46%; commercial, 35%; charitable, 15%; support group, 2%; and alternative medicine, 2%. Good interobserver correlation was found for both ratings instruments. The DISCERN tool rated Web sites as excellent (4%), good (7%), fair (29%), poor (39%), or very poor (21%). Only 5% of the Web sites provided one or more inaccurate pieces of information. Web sites were found deficient in topics covering etiology, late effects, prognosis, and treatment choices. Few sites offered information in languages other than English, and readability statistics showed an average required reading level of U.S. grade 12+ (the suggested level being grades 6-8 for an adult audience). The Internet is increasingly being used as a source of oncology information for patients and their families. Health care professionals should be actively involved in developing high-quality information for use in the next generation of Web sites.


Herman PM, D'Huyvetter K, Mohler MJ. Are health services research methods a match for CAM? Altern Ther Health Med. 2006 May-Jun;12(3):78-83. Review.
Program in Integrative Medicine, University of Arizona, Tucson, Arizona, USA.
Many complementary and alternative medicine (CAM) researchers believe that a new set of research methods is needed to study CAM. Health services research (HSR) is listed as a new research goal in the National Center for Complementary and Alternative Medicine 2005-2009 strategic plan. Does HSR offer solutions to the research needs of CAM? This article presents an overview of HSR, a summary of the HSR studies that have been published in CAM, and discussions of what HSR might offer CAM and what studies of CAM might offer conventional HSR. DISCUSSION: Our literature search, which was performed at the University of Arizona, found 84 published CAM HSR studies. A comparison of the search results-mostly surveys of CAM users or providers and economic outcome studies-with the breadth of topics that may be studied using HSR, showed that research in this field has not reached its potential. More work, including studies of interactions between patient, provider, and the system as well as patient-centered outcomes studies, is needed. Several areas in which CAM could benefit from HSR were identified and discussed. These included studies supporting the integration of CAM and conventional medicine, insurance coverage for CAM therapies, the development practice guidelines, and studies of the effectiveness and cost-effectiveness of CAM therapies and whole medical systems. The study of CAM, especially studies focusing on patients' attraction to CAM, may also help expand the topics and methods of conventional HSR. SUMMARY: HSR methods may address many of CAM's methodological challenges and improve clinical, patient-centered, and economic outcomes across all systems of care-both conventional and CAM.


Lian Z, Niwa K, Onogi K, Mori H, Harrigan RC, Tamaya T. Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-alpha-related mechanism. Oncol Rep. 2006 May;15(5):1133-6.
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido, Gifu-city 501-1194, Japan.
This study was performed to
examine the relationship between the anti-tumor effects of herbal medicine and endometrial carcinoma with ER-related mechanisms. An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-alpha mRNA, but not ER-beta mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism.


McAlister FA. The Canadian Hypertension Education Program--a unique Canadian initiative. Can J Cardiol. 2006 May 15;22(7):559-64.
Walter Mackenzie
Centre, University of Alberta Hospital, 8440-112 Street, Edmonton, Alberta, Canada.
While almost two-thirds of all strokes and one-half of all myocardial infarctions could be prevented if hypertensive individuals had their blood pressures optimally controlled, only a minority of hypertensive individuals (even in publicly funded health care systems with subsidization of medication costs) achieve target blood pressures. Traditional hypertension guidelines have had limited impact on hypertension management and control rates. As a result, the Canadian Hypertension Education Program was developed to address the perceived flaws in the traditional hypertension guideline approach. In the present article, the key features of the Canadian Hypertension Education Program methodology are reviewed, with attention to those factors thought to be critical to the successful translation of recommendations
into practice.


Passalacqua G, Bousquet PJ, Carlsen KH, Kemp J, Lockey RF, Niggemann B, Pawankar R, Price D, Bousquet J. ARIA update: I--Systematic review of complementary and alternative medicine for rhinitis and asthma. J Allergy Clin Immunol. 2006 May;117(5):1054-62.
Allergy and Respiratory Diseases, University of Genoa, Italy.

Complementary-alternative medicines are extensively used in the treatment of allergic rhinitis and asthma, but evidence-based recommendations are lacking. To provide evidence-based recommendations, the literature was searched by using MedLine and the Cochrane Library to March 2005 (Key words: Asthma [OR] Rhinitis, [AND] Complementary [OR] Alternative Medicine, [OR] Herbal, [OR] Acupuncture, [OR] Homeopathy, [OR] Alternative Treatment). Randomized trials, preferably double-blind and published in English, were selected. The articles were evaluated by a panel of experts. Quality of reporting was assessed by using the scale validated by Jadad. The methodology of clinical trials with complementary-alternative medicine was frequently inadequate. Meta-analyses provided no clear evidence for the efficacy of acupuncture in rhinitis and asthma. Some positive results were described with homeopathy in good-quality trials in rhinitis, but a number of negative studies were also found. Therefore it is not possible to provide evidence-based recommendations for homeopathy in the treatment of allergic rhinitis, and further trials are needed. A limited number of studies of herbal remedies showed some efficacy in rhinitis and asthma, but the studies were too few to make recommendations. There are also unresolved safety concerns. Therapeutic efficacy of complementary-alternative treatments for rhinitis and asthma is not supported by currently available evidence.


Sullivan R, Smith JE, Rowan NJ. Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect Biol Med. 2006 Spring;49(2):159-70. Review.
Cancer Research UK, 61 Lincoln's Inn Field, London W2A 3PX, United Kingdom.
Modern medical practice relies heavily on the use of highly purified pharmaceutical compounds whose purity can be easily assessed and whose pharmaceutical activity and toxicity show clear structure-function relationships. In contrast, many herbal medicines contain mixtures of natural compounds that have not undergone detailed chemical analyses and whose mechanism of action is not known. Traditional folk medicine and ethno-pharmacol
ogy coupled to bioprospecting have been an important source of many anticancer agents as well as other medicines. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicine. As the example of medicinal mushrooms demonstrates, however, translating traditional Eastern practices into acceptable evidence-based Western therapies is difficult. Different manufacturing standards, criteria of purity, and under-powered clinical trials make assessment of efficacy and toxicity by Western standards of clinical evidence difficult. Purified bioactive compounds derived from medicinal mushrooms are a potentially important new source of anticancer agents; their assimilation into Western drug discovery programs and clinical trials also provides a framework for the study and use of other traditional medicines.


Westergaard LG, Mao Q, Krogslund M, Sandrini S, Lenz S, Grinsted J. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial. Fertil Steril. 2006 May;85(5):1341-6.
Fertility Clinic Trianglen, Hellerup, Denmark.
OBJECTIVE: To evaluate the effect of acupuncture on reproductive outcome in patients treated with IVF/intracytoplasmic sperm injection (ICSI). One group of patients received acupuncture on the day of ET, another group on ET day and again 2 days later (i.e., closer to implantation day), and both groups were compared with a control group that did not receive acupuncture. DESIGN: Prospective, randomized trial. SETTING: Private fertility center. PATIENT(S): During the study period all patients receiving IVF or ICSI treatment were offered participation in the study. On the day of oocyte retrieval, patients were randomly allocated (with sealed envelopes) to receive acupuncture on the day of ET (ACU 1 group, n = 95), on that day and again 2 days later (ACU 2 group, n = 91), or no acupuncture (control group, n = 87). INTERVENTION(S): Acupuncture was performed immediately before and after ET (ACU 1 and 2 groups), with each session lasting 25 minutes; and one 25-minute session was performed 2 days later in the ACU 2 group. MAIN OUTCOME MEASURE(S): Clinical pregnancy and ongoing pregnancy rates in the three groups. RESULT(S): Clinical and ongoing pregnancy rates were significantly higher in the ACU 1 group as compared with controls (37 of 95 [39%] vs. 21 of 87 [26%] and 34 of 95 [36%] vs. 19 of 87 [22%]). The clinical and ongoing pregnancy rates in the ACU 2 group (36% and 26%) were higher than in controls, but the difference did not reach statistical difference. CONCLUSION(S): Acupuncture on the day of ET significantly improves the reproductive outcome of IVF/ICSI, compared with no acupuncture. Repeating acupuncture on ET day +2 provided no additional beneficial effect.


Zhang J, Wu TX, Liu GJ. Chinese herbal medicine for the treatment of pre-eclampsia. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD005126. Review.
BACKGROUND: Pre-eclampsia is a common disorder of pregnancy with uncertain etiology. In Chinese herbal medicines, a number of herbs are used for treating pre-eclampsia. Traditional Chinese medicine considers that, when a woman is pregnant, most of the blood of the mother is directed to the placenta to provide the baby with the required nutrition; other maternal organs may in consequence be vulnerable to damage. These organs include the liver, the spleen, and the kidneys. The general effects of Chinese herbal medicines that can protect these organs may be valuable in pre-eclampsia by encouraging vasodilatation, increasing blood flow, and decreasing platelet aggregation. The use of Chinese herbal medicine is often based on the individual and presence of traditional Chinese medicine symptoms. OBJECTIVES: To assess the effect of Chinese herbal medicine for treating pre-eclampsia and compare it with that of placebo, no treatment or Western medicine. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Groups Trial Register (31 March 2024), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2005), MEDLINE (1969 to December 2004), EMBASE (1984 to March 2004) and CBM (1978 to February 2005) and we handsearched several main journals published in China. SELECTION CRITERIA: Randomized controlled trials in which Chinese herbal medicine was used for treating pre-eclampsia. DATA COLLECTION AND ANALYSIS: One review author assessed trials for inclusion. The trials were also assessed by a second review author if there was any doubt about whether or not to include the trial. Analysis was not performed as there were no trials included in this review. MAIN RESULTS: No trials were suitable for inclusion in this review. AUTHORS' CONCLUSIONS: The effect of Chinese herbal medicine for treating pre-eclampsia remains unclear. There are currently no randomized controlled trials to address the efficacy and safety of Chinese herbal medicine for the treatment of pre-eclampsia. Well conducted randomized controlled trials are required.

 14917.     Alecrim-Andrade J, Maciel-Junior JA, Cladellas XC, Correa-Filho HR, Machado HC. Acupuncture in migraine prophylaxis: a randomized sham-controlled trial. Cephalalgia. 2006 May;26(5):520-9.

14918.     Aslan H, Zilberman Y, Arbeli V, Sheyn D, Matan Y, Liebergall M, Li JZ, Helm GA, Gazit D, Gazit Z. Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration. Tissue Eng. 2006 Apr;12(4):877-89.

14919.     Balde NM, Youla A, Balde MD, Kake A, Diallo MM, Balde MA, Maugendre D. Herbal medicine and treatment of diabetes in Africa: an example from Guinea. Diabetes Metab. 2006 Apr;32(2):171-5. 

14920.     Bang MS, Lim SH. Paraplegia caused by spinal infection after acupuncture. Spinal Cord. 2006 Apr;44(4):258-9.

14921.     Barlas P, Ting SL, Chesterton LS, Jones PW, Sim J. Effects of intensity of electroacupuncture upon experimental pain in healthy human volunteers: a randomized, double-blind, placebo-controlled study. Pain. 2006 May;122(1-2):81-9.

14922.     Bartecchi CE. Complementary medicine has no place in cardiovascular medicine. J Am Coll Cardiol. 2006 Apr 4;47(7):1498-9; author reply 1499-500.

14923.     Bharathi K, Gopakumar K, Swamy RK. Evaluation of nidana and samprapti in the case of tamakasvasa (bronchial asthma). Aryavaidyan 2005 Aug-Oct; 19(1);47-50.

14924.     Black SL. To the point: acupuncture and migraine. Lancet Neurol. 2006 May;5(5):382-3; author reply 383.

14925.     Borysowski J, Weber-Dabrowska B, Gorski A. Bacteriophage endolysins as a novel class of antibacterial agents. Exp Biol Med (Maywood). 2006 Apr;231(4):366-77. Review.

14926.     Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333.

14927.     Chen JJ, Chou TH, Duh CY, Chen IS. Cytotoxic dihydroagarofuranoid sesquiterpenes from the stem of Microtropis fokienensis. J Nat Prod. 2006 Apr;69(4):685-8.

14928.     Cherigo L, Pereda-Miranda R. Resin glycosides from the flowers of Ipomoea murucoides. J Nat Prod. 2006 Apr;69(4):595-9.

14929.     Colvin L, Forbes K, Fallon M. Difficult pain. BMJ. 2006 May 6;332(7549):1081-3. Review.

14930.     Daniels AL, Van Slambrouck S, Lee RK, Arguello TS, Browning J, Pullin MJ, Kornienko A, Steelant WF. Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. Oncol Rep. 2006 May;15(5):1327-31.

14931.     Dieterle S, Ying G, Hatzmann W, Neuer A. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study. Fertil Steril. 2006 May;85(5):1347-51.

14932.     Domar AD. Acupuncture and infertility: we need to stick to good science. Fertil Steril. 2006 May;85(5):1359-61; discussion 1368-70. Review.

14933.     Eleazer GP, Wieland D, Roberts E, Richeson N, Thornhill JT. Preparing medical students to care for older adults: the impact of a Senior Mentor Program. Acad Med. 2006 Apr;81(4):393-8.

14934.     Ezzo JM, Richardson MA, Vickers A, Allen C, Dibble SL, Issell BF, Lao L, Pearl M, Ramirez G, Roscoe J, Shen J, Shivnan JC, Streitberger K, Treish I, Zhang G. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002285. Review. 

14935.     Fink M, Rosted P, Bernateck M, Stiesch-Scholz M, Karst M. Acupuncture in the treatment of painful dysfunction of the temporomandibular joint -- a review of the literature. Forsch Komplementarmed. 2006 Apr;13(2):109-15.

14936.     Folmer F, Blasius R, Morceau F, Tabudravu J, Dicato M, Jaspars M, Diederich M. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem Pharmacol. 2006 Apr 14;71(8):1206-18.

14937.     Fu ZH, Chen XY, Lu LJ, Lin J, Xu JG. Immediate effect of Fu's subcutaneous needling for low back pain. Chin Med J (Engl). 2006 Jun 5;119(11):953-6.

14938.     Gagnier JJ, van Tulder M, Berman B, Bombardier C. Herbal medicine for low back pain. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD004504. Review.

14939.     Gold PB, Glynn SM, Mueser KT. Challenges to implementing and sustaining comprehensive mental health service programs. Eval Health Prof. 2006 Jun;29(2):195-218.

14940.     Hall KB, Tett SE, Nissen LM. Perceptions of the influence of prescription medicine samples on prescribing by family physicians. Med Care. 2006 Apr;44(4):383-7.

14941.     Hargrave DR, Hargrave UA, Bouffet E. Quality of health information on the Internet in pediatric neuro-oncology. Neuro-oncol. 2006 Apr;8(2):175-82.

14942.     Huan SK, Lee HH, Liu DZ, Wu CC, Wang CC. Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. Toxicology. 2006 Jun 1;223(1-2):136-43.

14943.     Hyman MA. The evolution of research: meeting the needs of systems medicine, part 1. Altern Ther Health Med. 2006 May-Jun;12(3):10-1. Review.

14944.     Irwin CE Jr. To test or not to test: screening for substance use in adolescents. J Adolesc Health. 2006 Apr;38(4):329-31.

14945.     Kaplan S. Yoga and the battlefield of ethics: highlighting an infusion model for ethics education. Sci Eng Ethics. 2006 Apr;12(2):391-8.

14946.     Keeling D, Davidson S, Watson H; Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology. The management of heparin-induced thrombocytopenia. Br J Haematol. 2006 May;133(3):259-69.

14947.     Kim IJ, Kang JK, Lee SA. Factors contributing to the use of complementary and alternative medicine by people with epilepsy. Epilepsy Behav. 2006 May;8(3):620-4.

14948.     Kinney AJ. Metabolic engineering in plants for human health and nutrition. Curr Opin Biotechnol. 2006 Apr;17(2):130-8.

14949.     Kormosh N, Laktionov K, Antoshechkina M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother Res. 2006 May;20(5):424-5.

14950.     Krivoy N, Habib M, Azzam ZS. Ethnic differences in population approach and experience regarding complementary-alternative medicine (CAM). Pharmacoepidemiol Drug Saf. 2006 May;15(5):348-53.

14951.     Lanzotti V. The analysis of onion and garlic. J Chromatogr A. 2006 Apr 21;1112(1-2):3-22.

14952.     Laurenson M. Working complementary therapies into mainstream health care. Br J Nurs. 2006 Apr 13-26;15(7):356-8.

14953.     Manosroi J, Dhumtanom P, Manosroi A. Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines. Cancer Lett. 2006 Apr 8;235(1):114-20.

14954.     Marian F, Widmer M, Herren S, Donges A, Busato A. Physicians' philosophy of care: a comparison of complementary and conventional medicine. Forsch Komplementarmed. 2006 Apr;13(2):70-7.

14955.     Maruyama M, Tomita N, Iwasaki K, Ootsuki M, Matsui T, Nemoto M, Okamura N, Higuchi M, Tsutsui M, Suzuki T, Seki T, Kaneta T, Furukawa K, Arai H. Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial. J Am Geriatr Soc. 2006 May;54(5):869-71.

14956.     Melnick SJ. Developmental therapeutics: review of biologically based complementary and alternative medicine (CAM) therapies for potential application in children with cancer-part II. J Pediatr Hematol Oncol. 2006 May;28(5):271-85. Review.

14957.     Melnick SJ. Developmental therapeutics: review of biologically based CAM therapies for potential application in children with cancer: part I. J Pediatr Hematol Oncol. 2006 Apr;28(4):221-30. Review.

14958.     Militao GC, Dantas IN, Pessoa C, Falcao MJ, Silveira ER, Lima MA, Curi R, Lima T, Moraes MO, Costa-Lotufo LV. Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells. Life Sci. 2006 Apr 11;78(20):2409-17.

14959.     Moffet HH. Acupuncture for upper-extremity rehabilitation in chronic stroke. Arch Phys Med Rehabil. 2006 Apr;87(4):593-4; author reply 594-5.

14960.     Mruthyumjaya Rao M, Deep VC, Padhi MM, Das B, Nanda GC, Sahu DP. Application of leech therapy in the management of svitra (leukoderma). Aryavaidyan 2005 Feb-Apr; 19(3);144-147.

14961.     Murphy SP, Barr SI. Recommended Dietary Allowances should be used to set Daily Values for nutrition labeling. Am J Clin Nutr. 2006 May;83(5):1223S-1227S.

14962.     Norton SA. Whither medical botany? CMAJ. 2006 Jun 20;174(13):1877.

14963.     Panda AK, Tripathy PC, Nandy A. Clinical evaluation of swerta chirata in the treatment of P. vivax malaria. Aryavaidyan 2005 Aug-Oct; 19(1);39-42.

14964.     Passalacqua G, Bousquet PJ, Carlsen KH, Kemp J, Lockey RF, Niggemann B, Pawankar R, Price D, Bousquet J. ARIA update: I--Systematic review of complementary and alternative medicine for rhinitis and asthma. J Allergy Clin Immunol. 2006 May;117(5):1054-62.

14965.     Rankin-Box D. Shaping medical knowledge II: bias and balance. Complement Ther Clin Pract. 2006 May;12(2):77-9.

14966.     Raveendaran N, Ajjan N, Sekhar C, Rajesh SR. Factors influence contract farming of medicinal plant � the case of coleus (coleus forskohlii) � in Tamil Nadu. Aryavaidyan 2005 Aug-Oct; 19(1);32-38.

14967.     Reynolds D. Examining spirituality among women with breast cancer. Holist Nurs Pract. 2006 May-Jun;20(3):118-21. Review.

14968.     Robb WJ. Self-healing: a concept analysis. Nurs Forum. 2006 Apr-Jun;41(2):60-77. Review.

14969.     Robinson N. Integrated traditional Chinese medicine. Complement Ther Clin Pract. 2006 May;12(2):132-40.

14970.     Sall AA, Segeral O, Reynes JM, Lay S, Ouk V, Hak CR, Keo CL, Lefait RR, Delfraissy JF, Fontanet A.  Immunosuppression and GB virus C-RNA detection among HIV-infected patients in Cambodia. AIDS. 2006 May 12;20(8):1199-201.

14971.     Saunders B, Gower N. Prominent doctors and scientists reject Lancet report on homoeopathy. S Afr Med J. 2006 Apr;96(4):260, 262; discussion 262.

14972.     Schneider A, Enck P, Streitberger K, Weiland C, Bagheri S, Witte S, Friederich HC, Herzog W, Zipfel S. Acupuncture treatment in irritable bowel syndrome. Gut. 2006 May;55(5):649-54.

14973.     Simpson CA. Complementary medicine in chronic pain treatment. Phys Med Rehabil Clin N Am. 2006 May;17(2):451-72, viii. Review.

14974.     Smith C, Coyle M, Norman RJ. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer. Fertil Steril. 2006 May;85(5):1352-8.

14975.     Srikanth N, Dua M, Bansal P, Misra DK. Role of eye exercise, topical and internal medication in myopia � a clinical study. Aryavaidyan 2005 Feb-Apr; 19(3);154-160.

14976.     Sumit K. A response to 'Evaluation of capsaicin ointment at the Korean hand acupressure point K-D2 for prevention of postoperative nausea and vomiting'. Anaesthesia. 2006 Jun;61(6):617; author reply 617.

14977.     Sung L, Feldman BM. N-of-1 trials: innovative methods to evaluate complementary and alternative medicines in pediatric cancer. J Pediatr Hematol Oncol. 2006 Apr;28(4):263-6.

14978.     Talokar SS, Deshmukh AA, Vadlamudi VP, Vasulkar RA, Shende NG. Study of haemato biochemical analysis of serum of helminth infested goats during the course of treatment with a composite herbal extract. Aryavaidyan 2005 Aug-Oct; 19(1);43-46.

14979.     Taylor AW, MacLennan AH, Avery JC. Postmenopausal hormone therapy: who now takes it and do they differ from non-users? Aust N Z J Obstet Gynaecol. 2006 Apr;46(2):128-35.

14980.     Tillisch K. Complementary and alternative medicine for functional gastrointestinal disorders. Gut. 2006 May;55(5):593-6.

14981.     Vas J, Perea-Milla E, Mendez C, Silva LC, Herrera Galante A, Aranda Regules JM, Martinez Barquin DM, Aguilar I, Faus V.  Efficacy and safety of acupuncture for the treatment of non-specific acute low back pain: a randomised controlled multicentre trial protocol [ISRCTN65814467].. BMC Complement Altern Med. 2006 Apr 21;6:14.

14982.     Vasulkar RA, Vadlamudi VP, Deshmukh AA. Anthelmintic evaluation of a composite herbal extract formulation. Aryavaidyan 2005 Aug-Oct; 19(1);58-60.

14983.     Vickery CE, Cotugna N. Complementary and alternative medicine education in dietetics programs: existent but not consistent. J Am Diet Assoc. 2006 Jun;106(6):860-6.

14984.     Wahlberg A. Bio-politics and the promotion of traditional herbal medicine in Vietnam. Health (London). 2006 Apr;10(2):123-47.

14985.     Wallace MB, Sullivan D, Rustgi AK; AITGN Symposium Faculty.  Advanced imaging and technology in gastrointestinal neoplasia: summary of the AGA-NCI Symposium October 4-5, 2004. Gastroenterology. 2006 Apr;130(4):1333-42.

14986.     Wan JM, Sit WH, Lee CL, Fu KH, Chan DK. Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury. Int Immunopharmacol. 2006 May;6(5):750-8.

14987.     Wang F, Hua H, Pei Y, Chen D, Jing Y. Triterpenoids from the resin of Styrax tonkinensis and their antiproliferative and differentiation effects in human leukemia HL-60 cells. J Nat Prod. 2006 May;69(5):807-10.

14988.     Wang KW, Mao JS, Tai YP, Pan YJ. Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2274-7.

14989.     Westergaard LG, Mao Q, Krogslund M, Sandrini S, Lenz S, Grinsted J. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial. Fertil Steril. 2006 May;85(5):1341-6.

14990.     Wilson KM, Klein JD, Sesselberg TS, Yussman SM, Markow DB, Green AE, West JC, Gray NJ. Use of complementary medicine and dietary supplements among U.S. adolescents. J Adolesc Health. 2006 Apr;38(4):385-94.

14991.     Winnick TA. Medical doctors and complementary and alternative medicine: the context of holistic practice. Health (London). 2006 Apr;10(2):149-73.

14992.     Wojcikowski K, Johnson DW, Gobe G. Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies. J Lab Clin Med. 2006 Apr;147(4):160-6. Review.

14993.     Xiao WL, Huang SX, Zhang L, Tian RR, Wu L, Li XL, Pu JX, Zheng YT, Lu Y, Li RT, Zheng QT, Sun HD. Nortriterpenoids from Schisandra lancifolia. J Nat Prod. 2006 Apr;69(4):650-3.

14994.     Xue CC, Li CG, Hugel HM, Story DF. Does acupuncture or Chinese herbal medicine have a role in the treatment of allergic rhinitis? Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):175-9. Review.

14995.     Yadav PS, Sharma AK. Hypertension: An ayurvedic perspective. Aryavaidyan 2005 Nov � 2006 Jan; 19(2);86-92.

14996.     Yang H, Chen D, Cui QC, Yuan X, Dou QP. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65.

14997.     Zaffani S, Cuzzolin L, Benoni G. Herbal products: behaviors and beliefs among Italian women. Pharmacoepidemiol Drug Saf. 2006 May;15(5):354-9.