Some Selected Abstracts:


Moodley P, Coovadia YM, Sturm AW. Intravenous glucose preparation as the source of an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infections in the neonatal unit of a regional hospital in KwaZulu-Natal. S Afr Med J. 2005 Nov;95(11):861-4.

Department of Medical Microbiology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

In the last week of May 2005, staff at Mahatma Gandhi Memorial Hospital in KwaZulu-Natal realised that many babies in the high-care nursery ward had bloodstream infections involving Klebsiella pneumoniae bacteria. Attempts to identify a common source of infection failed. The ward was therefore closed and new babies needing high care were admitted to another empty ward. Despite this, babies still became infected. This resulted in a request for assistance from the Department of Medical Microbiology of the Nelson R Mandela School of Medicine. A search for common factors through case history studies of the 26 infected babies showed that blood cultures of the babies remained positive despite the administration of appropriate antibiotics. Different options that could explain this were investigated. The organism was found in intravenous glucose preparations used for multiple dosing. Unopened vials of the same medication were sterile. The nursery was found to lack proper hand-wash facilities and to be overcrowded and understaffed. Reinforcement of hand hygiene and a ban on the multiple dosing of medicines stopped the outbreak. In conclusion, this outbreak resulted from a combination of factors among which lack of hand hygiene and multiple dosing of an intravenous glucose preparation were most significant.

Diagnosis, Diagnostics, Immunodiagnosis & Immunodiagnostics:  

13960 .  Earsing KA, Hobson DB, White KM. Best-practice protocols: preventing central line infection. Nurs Manage. 2005 Oct;36(10):18-24.

13961.  Jensen PA, Lambert LA, Iademarco MF, Ridzon R; CDC. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. 2005 Dec 30;54(17):1-141.

13962.   Pruitt B. Keeping respiratory syncytial virus at bay. Nursing. 2005 Nov;35(11):62-4. Review. 

13963.   Salgado CD, O'Grady N, Farr BM. Prevention and control of antimicrobial-resistant infections in intensive care patients. Crit Care Med. 2005 Oct;33(10):2373-82. Review.

13964.    Shorr AF, Kollef MH. Ventilator-associated pneumonia: insights from recent clinical trials. Chest. 2005 Nov;128(5 Suppl 2):583S-591S.

13965.   Soylu A, Kavukcu S, Erdur B, Demir K, Turkmen MA. Multisystemic leukocytoclastic vasculitis affecting the central nervous system. Pediatr Neurol. 2005 Oct;33(4):289-91. 



13966.     Baughman RP, Glauser MP. Managing serious infections in the hospital: a new model. Clin Microbiol Infect. 2005 Oct;11 Suppl 5:1-3.  

13967.   Bustamante CI. Treatment of Candida infection: a view from the trenches! Curr Opin Infect Dis. 2005 Dec;18(6):490-5. Review.

13968.   El Helali N, Carbonne A, Naas T, Kerneis S, Fresco O, Giovangrandi Y, Fortineau N, Nordmann P, Astagneau P. Nosocomial outbreak of staphylococcal scalded skin syndrome in neonates: epidemiological investigation and control. J Hosp Infect. 2005 Oct;61(2):130-8.

13969.   Lode H. Management of serious nosocomial bacterial infections: do current therapeutic options meet the need? Clin Microbiol Infect. 2005 Oct;11(10):778-87. Review.

13970.   Rello J, Diaz E, Rodriguez A.  Advances in the management of pneumonia in the intensive care unit: review of current thinking.Clin Microbiol Infect. 2005 Oct;11 Suppl 5:30-8. Review.

13971.   Sun HK, Kuti JL, Nicolau DP. Pharmacodynamics of antimicrobials for the empirical treatment of nosocomial pneumonia: a report from the OPTAMA Program. Crit Care Med. 2005 Oct;33(10):2222-7.

13972.   Suresh GK. Improper stool disposal in neonatal units in developing countries: an unrecognized hazard for nosocomial infection. Pediatrics. 2005 Nov;116(5):1265.  

13973.   Weinstein RA, Bonten MJ. Controlling antibiotic-resistant bacteria: what's an intensivist to do? Crit Care Med. 2005 Oct;33(10):2446-7.  



13974.     Chudleigh J, Fletcher M, Gould D. Infection control in neonatal intensive care units. J Hosp Infect. 2005 Oct;61(2):123-9.

13975.  O'Neill JK, Rust P, Knight D, Ricketts DM. Greens could be bad for you: a study of the inappropriate use of theater greens. South Med J. 2005 Oct;98(10):1053-4.  

13976.   Pittet D, Donaldson L. Clean Care is Safer Care: a worldwide priority. Lancet. 2005 Oct 8;366(9493):1246-7.  

13977.   Robeznieks A. ICU effort saved lives, money: organizers. More than 70 hospitals took part in the Keystone: ICU program. Mod Healthc. 2005 Oct 17;35(42):16.   

13978.  Soulsby EJ. Resistance to antimicrobials in humans and animals. BMJ. 2005 Nov 26;331(7527):1219-20.